Volume 45 Issue 8
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Article Navigation >  Journal of Kunming Medical University  > 2024  >  45(8): 17-23
Xibing Zhang, Ling Niu, Fang Liu, Jianghua Ran. The Effects of Caloric Restriction and Intermittent Fasting on Inflammation and Metabolic Diseases[J]. Journal of Kunming Medical University, 2024, 45(12): 1-9. doi: 10.12259/j.issn.2095-610X.S20241201
Citation: Hongxiu YANG, Zhongshan ZHU. Effect of HPRT1 Gene Expression on Overall Survival of Patients with Lung Adenocarcinoma[J]. Journal of Kunming Medical University, 2024, 45(8): 17-23. doi: 10.12259/j.issn.2095-610X.S20240803
shu

Effect of HPRT1 Gene Expression on Overall Survival of Patients with Lung Adenocarcinoma

doi: 10.12259/j.issn.2095-610X.S20240803

  • Dept. of Oncology，The 2nd People’s Hospital of Hunan Province，Changsha Hunan 410007，China

  • Received Date: 2024-04-02
    Available Online: 2024-07-06
  • Publish Date: 2024-08-05
    Abstract
  •   Objective   To explore the expression characteristics, prognostic effect, functional activation and immune infiltration of HPRT1 gene in lung adenocarcinoma.   Methods  The data of adenocarcinoma of the lung from TCGA and multiple GEO databases were collected and analyzed. The relationship between HPRT1 expression level and overall survival （OS） was compared and validated, and the functional enrichment of upregulated genes in the HPRT1 high-expression group was analyzed using ClusterProfiler. Furthermore, the infiltration levels of immune cells in lung adenocarcinoma were calculated using TIMER and CIBERSORT algorithms and compared between the HPRT1 high- and low-expression groups.   Results  The expression of HPRT1 was significantly upregulated in lung adenocarcinoma tissues, and TCGA dataset analysis showed the patients with high expression of HPRT1 gene had a poorer overall survival （OS） prognosis （P < 0.01）. Validation through two GEO datasets also shows that high expression of the HPRT1 gene is associated with a worse OS prognosis （GSE13213, P < 0.01, GSE67639, P < 0.001）. Differential analysis indicates that among patients with high expression, the expression levels of 683 genes are significantly upregulated, with these upregulated genes primarily enriched in signaling pathways related to cancer, such as p53 and the cell cycle. Analysis of immune cell infiltration levels using TIMER and CIBERSORT algorithms reveals that in the group with high expression and poor prognosis, the levels of B cells and CD4 T cells are lower （P < 0.05）.  Conclusion   The higher the expression level of the HPRT1 gene, the significantly worse the overall survival of patients with lung adenocarcinoma, and in patients with high expression levels, the p53 signaling pathway is upregulated, and the infiltration level of B cells and CD4T cells is significantly decreased.
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