Volume 45 Issue 8
Aug.  2024
Turn off MathJax
Article Contents
Abstract
References
Relative Articles
Article Navigation >  Journal of Kunming Medical University  > 2024  >  45(8): 17-23
Hongxiu YANG, Zhongshan ZHU. Effect of HPRT1 Gene Expression on Overall Survival of Patients with Lung Adenocarcinoma[J]. Journal of Kunming Medical University, 2024, 45(8): 17-23. doi: 10.12259/j.issn.2095-610X.S20240803
Citation: Hongxiu YANG, Zhongshan ZHU. Effect of HPRT1 Gene Expression on Overall Survival of Patients with Lung Adenocarcinoma[J]. Journal of Kunming Medical University, 2024, 45(8): 17-23. doi: 10.12259/j.issn.2095-610X.S20240803
shu

Effect of HPRT1 Gene Expression on Overall Survival of Patients with Lung Adenocarcinoma

doi: 10.12259/j.issn.2095-610X.S20240803

  • Dept. of Oncology，The 2nd People’s Hospital of Hunan Province，Changsha Hunan 410007，China

  • Received Date: 2024-04-02
    Available Online: 2024-07-06
  • Publish Date: 2024-08-05
    Abstract
  •   Objective   To explore the expression characteristics, prognostic effect, functional activation and immune infiltration of HPRT1 gene in lung adenocarcinoma.   Methods  The data of adenocarcinoma of the lung from TCGA and multiple GEO databases were collected and analyzed. The relationship between HPRT1 expression level and overall survival （OS） was compared and validated, and the functional enrichment of upregulated genes in the HPRT1 high-expression group was analyzed using ClusterProfiler. Furthermore, the infiltration levels of immune cells in lung adenocarcinoma were calculated using TIMER and CIBERSORT algorithms and compared between the HPRT1 high- and low-expression groups.   Results  The expression of HPRT1 was significantly upregulated in lung adenocarcinoma tissues, and TCGA dataset analysis showed the patients with high expression of HPRT1 gene had a poorer overall survival （OS） prognosis （P < 0.01）. Validation through two GEO datasets also shows that high expression of the HPRT1 gene is associated with a worse OS prognosis （GSE13213, P < 0.01, GSE67639, P < 0.001）. Differential analysis indicates that among patients with high expression, the expression levels of 683 genes are significantly upregulated, with these upregulated genes primarily enriched in signaling pathways related to cancer, such as p53 and the cell cycle. Analysis of immune cell infiltration levels using TIMER and CIBERSORT algorithms reveals that in the group with high expression and poor prognosis, the levels of B cells and CD4 T cells are lower （P < 0.05）.  Conclusion   The higher the expression level of the HPRT1 gene, the significantly worse the overall survival of patients with lung adenocarcinoma, and in patients with high expression levels, the p53 signaling pathway is upregulated, and the infiltration level of B cells and CD4T cells is significantly decreased.
    • FullText(HTML)
    • References(20)
  • [1]
    Tewari K S,Colombo N,Monk B J,et al. Pembrolizumab or placebo plus chemotherapy with or without bevacizumab for persistent,recurrent,or metastatic cervical cancer: Subgroup analyses from the KEYNOTE-826 randomized clinical trial[J]. JAMA Oncol,2024,10(2):185-192. doi: 10.1001/jamaoncol.2023.5410
    [2]
    Ma W,Zeng J,Montoya D J,et al. Labyrinthin expression is associated with poor prognosis in patients with non-small cell lung cancer[J]. Cancers (Basel),2023,15(3):924. doi: 10.3390/cancers15030924
    [3]
    Wang X S,Bai Y F,Verma V,et al. Randomized trial of first-line tyrosine kinase inhibitor with or without radiotherapy for synchronous oligometastatic EGFR-mutated non-small cell lung cancer[J]. J Natl Cancer Inst,2023,115(6):742-748. doi: 10.1093/jnci/djac015
    [4]
    Chen F,Byrd A L,Liu J,et al. Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors[J]. Nat Commun,2023,14(1):336. doi: 10.1038/s41467-023-35784-x
    [5]
    John P,Sudandiradoss C. A comprehensive integrated gene network construction to explore the essential role of Notch 1 in lung adenocarcinoma (LUAD)[J]. J Biomol Struct Dyn,2024,1-13.
    [6]
    Xu H,Hu Y,Peng X,et al. Prediction of prognostic and immune therapy response in lung adenocarcinoma based on MHC-I-related genes[J]. Immunopharmacol Immunotoxicol,2024,46(1):93-106. doi: 10.1080/08923973.2023.2261146
    [7]
    Gurioli G,Conteduca V,Brighi N,et al. Circulating tumor cell gene expression and plasma AR gene copy number as biomarkers for castration-resistant prostate cancer patients treated with cabazitaxel[J]. BMC Med,2022,20(1):48. doi: 10.1186/s12916-022-02244-0
    [8]
    Miao J,Kang L,Lan T,et al. Identification of optimal reference genes in golden Syrian hamster with ethanol- and palmitoleic acid-induced acute pancreatitis using quantitative real-time polymerase chain reaction[J]. Animal Model Exp Med,2023,6(6):609-618. doi: 10.1002/ame2.12321
    [9]
    Chen L,He X,Yi S,et al. Six glycolysis-related genes as prognostic risk markers can predict the prognosis of patients with head and neck squamous cell carcinoma[J]. Biomed Res Int,2021,2021:8824195.
    [10]
    Gurioli G, Conteduca V, Brighi N, et al. Circulating tumor cell gene expression and plasma AR gene copy number as biomarkers for castration-resistant prostate cancer patients treated with cabazitaxel[J]. BMC Med,2022,20(1):48.
    [11]
    Goldman M J,Craft B,Hastie M,et al. Visualizing and interpreting cancer genomics data via the Xena platform[J]. Nat Biotechnol,2020,38(6):675-678. doi: 10.1038/s41587-020-0546-8
    [12]
    Tomida S,Takeuchi T,Shimada Y,et al. Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis[J]. J Clin Oncol,2009,27(17):2793-2799. doi: 10.1200/JCO.2008.19.7053
    [13]
    Gentles A J,Bratman S V,Diehn M,et al. Integrating tumor and stromal gene expression signatures with clinical indices for survival stratification of early-stage non-small cell lung cancer[J]. J Natl Cancer Inst,2015,107(10):djv211. doi: 10.1093/jnci/djv211
    [14]
    Uhlen M,Zhang C,Lee S,et al. A pathology atlas of the human cancer transcriptome[J]. Science,2017,357(6352):eaan2507. doi: 10.1126/science.aan2507
    [15]
    Yan Z,Wang Q,Lu Z,et al. OSluca: An interactive web server to evaluate prognostic biomarkers for lung cancer[J]. Front Genet,2020,11:420. doi: 10.3389/fgene.2020.00420
    [16]
    Yu G,Wang L G,Han Y,et al. clusterProfiler: An R package for comparing biological themes among gene clusters[J]. OMICS,2012,16(5):284-287. doi: 10.1089/omi.2011.0118
    [17]
    Wu M,Jiang L. Hydroxysteroid 17-beta dehydrogenase 6 is a prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma[J]. Dig Dis Sci,2022,67(1):146-158. doi: 10.1007/s10620-021-06832-7
    [18]
    Chen B,Khodadoust M S,Liu C L,et al. Profiling tumor infiltrating immune cells with CIBERSORT[J]. Methods Mol Biol,2018,1711:243-259.
    [19]
    Mavridis K,Stravodimos K,Scorilas A. Quantified KLK15 gene expression levels discriminate prostate cancer from benign tumors and constitute a novel independent predictor of disease progression[J]. Prostate,2013,73(11):1191-201. doi: 10.1002/pros.22667
    [20]
    朱中山,杨洲,江承川,等. 肺腺癌患者PLA2G1B表达情况与预后的相关性[J]. 昆明医科大学学报,2022,43(9):70-76.
    • Relative Articles(20)

  • Relative Articles

    [1] Haijun LOU, Zhenyu ZHANG, Sureyan ALIMUJIANG, Menggen MENG, Hang CHEN, Muli WUDU. Expression Characteristics and Clinical Pathological Features of TMEM33 in Lung Adenocarcinoma. Journal of Kunming Medical University, 2025, 46(3): 19-26.  doi: 10.12259/j.issn.2095-610X.S20250304
    [2] Shengqiang YANG, Ping WANG. Effect of Hsp90 Inhibitor Ganetespib Combined with Pemetrexed on Lung Adenocarcinoma Cells. Journal of Kunming Medical University, 2024, 45(7): 30-41.  doi: 10.12259/j.issn.2095-610X.S20240705
    [3] Wangxun SHEN, Yinyu YANG, Canwei LI, Jinrong YANG, Sijing WU, Huajun ZHAO, Xiaoyu TUO. Expression and Clinical Significance of ROR1 in Different Histologic Types of Invasive Lung Adenocarcinoma. Journal of Kunming Medical University, 2024, 45(5): 60-65.  doi: 10.12259/j.issn.2095-610X.S20240509
    [4] Fei SONG, Jiayin CHE, Ming HUANG, Dan XU, Hongyang LI, Dingkun LI, Yingying XIANG. The Role of Radioactive Iodine-125 Particles in EMT and Clinical Treatment of Lung Adenocarcinoma. Journal of Kunming Medical University, 2023, 44(1): 140-143.  doi: 10.12259/j.issn.2095-610X.S20230101
    [5] Shiqi MA, Yi DING, Min LI, Mengci WANG, Siyu ZHANG, Shumei FENG. LINC00341 Inhibits the Proliferation of Lung Adenocarcinoma Cells Through the MAPK Pathway. Journal of Kunming Medical University, 2023, 44(4): 1-8.  doi: 10.12259/j.issn.2095-610X.S20230403
    [6] Bangqing LIU, Jianfeng LI, Xiaohui LIU, Jinnan ZHANG, Jinping LIANG. MiR-196b Promotes Proliferation and Migration of Lung Adenocarcinoma by Targeting ERG. Journal of Kunming Medical University, 2023, 44(10): 83-91.  doi: 10.12259/j.issn.2095-610X.S20231023
    [7] Maofang WU, Yongchun ZHOU, Jingjing CAI, Xin MO, Yinwei LI, Jiahui MAO. EGFR Gene Mutation State and Its Clinical Significance in Multi-nodular Lung Adenocarcinoma in Yunnan Province. Journal of Kunming Medical University, 2022, 43(2): 60-66.  doi: 10.12259/j.issn.2095-610X.S20220215
    [8] Huajun ZHAO, Guoqing PAN, Ying TANG, Zhiyuan WANG, Xiaowei ZHAO, Xiaoyu TUO. Expressions of ROR1 in Lung Adenocarcinoma and Its Relationship with Spread Through Air Apace. Journal of Kunming Medical University, 2022, 43(11): 22-29.  doi: 10.12259/j.issn.2095-610X.S20221128
    [9] Zhongshan ZHU, Zhou YANG, Chengchuan JIANG, Xiaobing LI, Dou REN, Cheng HUANG, Weiwei ZHANG, Xiangjun LI, Shunli ZHAO. An Analysis of PLA2G1B Expression and Prognosis in Patients with Lung Adenocarcinoma. Journal of Kunming Medical University, 2022, 43(9): 70-76.  doi: 10.12259/j.issn.2095-610X.S20220912
    [10] Ying-xia WANG, Qin HE, Guo-fang WANG, Xuan ZHANG. Expression and Significance of microRNA-21 and EGFR in Non-small Cell Lung Cancer. Journal of Kunming Medical University, 2021, 42(8): 101-105.  doi: 10.12259/j.issn.2095-610X.S20210818
    [11] Ye YUAN, Jian CHANG, Dong-bo LIU, Bao-cheng JIANG. Lymph Node Metastasis of Mixed Early Gastric Cancer and Its Influence on Prognosis. Journal of Kunming Medical University, 2021, 42(3): 79-83.  doi: 10.12259/j.issn.2095-610X.S20210321
    [12] Hong-min DUAN, Nan CHEN, Yong-yan YANG, Yun-xia LI, Jin-xiang FENG, Hang LI, Xiu-wen HUANG, Dong-jin LV, Ming ZHANG, Yu-tao ZHAO. Effects and Mechanism of Anlotinib on Radiosensitivity of Non-small Cell Lung Cancer Cell Lines A549. Journal of Kunming Medical University, 2021, 42(8): 40-46.  doi: 10.12259/j.issn.2095-610X.S20210808
    [13] Yan-fen MA, Jian HU, Ning ZHANG, Qian WU, Xiao-qin WANG. Changes and Abnormal Patterns of Coagulation Indicators in Patients with Lung Adenocarcinoma and Tuberculosis Pleural Effusion. Journal of Kunming Medical University, 2021, 42(10): 145-150.  doi: 10.12259/j.issn.2095-610X.S20211021
    [14] Ma Guo Yu , Xiong Qing , Jiang Guo Qing , Yang Jia Tian , Mu Yun Zhen . . Journal of Kunming Medical University, 2020, 41(07): 30-37.
    [15] Wu Qi Yan , Bian Ge Yuan , Cheng Hui Jun, Li Jiao Xia , Wang Shu Ting , Huang Zhao Lue . . Journal of Kunming Medical University, 2020, 41(09): 32-37.
    [16] Wang Ji Yan , Duan Yong . . Journal of Kunming Medical University, 2018, 39(12): 1-4.
    [17] Zhu Zhong Shan , Yan Wen Hui , Li Xiao Bing , Yang Zhou , Bai Peng . Driver Genes Mutation and Survival Analysis in 200 Patients with Pulmonary Adenocarcinoma Brain Metastasis. Journal of Kunming Medical University, 2018, 39(08): 47-50.
    [18] Wang Jia Zhu , Diao Xian Min , Kang Zhen , Chang Run Sheng , Lei Zi Fa , Sun Li , Wang Zhao Min , Cao E , Li Wen Hui . The Pathological Changes of Occupational Lung Cancer in Yunnan Gejiu's Tin Miners and the Therapy and Survival Analysis of 97 Lung Squamous Carcinoma. Journal of Kunming Medical University, 2017, 38(04): 52-57.
    [19] Wang Hua . . Journal of Kunming Medical University,
    [20] . Expression of study of Nestin in Lung Adenocarcinoma Cell Line A549. Journal of Kunming Medical University,
    • Supplements(0)
    • Cited By

  • Cited by

    Periodical cited type(2)

    1. 唐斌，甘树发. 2018年重庆市江北区中小学生近视发生危险因素分析. 预防医学情报杂志. 2020(12): 1594-1599 .
    2. 王春梅. 用健康坐姿维护健康预防近视. 医学食疗与健康. 2019(14): 206+208 .

    Other cited types(1)

  • 加载中
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 26.6 %FULLTEXT: 26.6 %META: 72.7 %META: 72.7 %PDF: 0.7 %PDF: 0.7 %FULLTEXTMETAPDF
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 4.0 %其他: 4.0 %China: 3.6 %China: 3.6 %上海: 4.5 %上海: 4.5 %东莞: 0.1 %东莞: 0.1 %北京: 46.3 %北京: 46.3 %南充: 0.0 %南充: 0.0 %哈尔滨: 0.0 %哈尔滨: 0.0 %安那罕: 0.1 %安那罕: 0.1 %宣城: 0.1 %宣城: 0.1 %庆阳: 0.0 %庆阳: 0.0 %张家口: 0.1 %张家口: 0.1 %无锡: 0.1 %无锡: 0.1 %昆明: 0.1 %昆明: 0.1 %杭州: 0.1 %杭州: 0.1 %桂林: 0.1 %桂林: 0.1 %武汉: 0.2 %武汉: 0.2 %波士顿: 0.0 %波士顿: 0.0 %深圳: 0.1 %深圳: 0.1 %芒廷维尤: 1.6 %芒廷维尤: 1.6 %蚌埠: 0.3 %蚌埠: 0.3 %衢州: 0.0 %衢州: 0.0 %西宁: 3.8 %西宁: 3.8 %贵阳: 0.0 %贵阳: 0.0 %赣州: 0.1 %赣州: 0.1 %郑州: 0.9 %郑州: 0.9 %银川: 0.0 %银川: 0.0 %锦州: 0.0 %锦州: 0.0 %长沙: 0.0 %长沙: 0.0 %驻马店: 33.3 %驻马店: 33.3 %其他China上海东莞北京南充哈尔滨安那罕宣城庆阳张家口无锡昆明杭州桂林武汉波士顿深圳芒廷维尤蚌埠衢州西宁贵阳赣州郑州银川锦州长沙驻马店

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(5)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (675) PDF downloads(21) Cited by(3)
    Proportional views
    Related

    Copyright © 《昆明医科大学学报》编辑部  滇ICP备00000000号-0

    Publishing: 昆明医科大学学报编辑部

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return