A Mendelian Randomization Study on Alzheimer’ s Disease and Sarcopenia

Rui LI; Jianpei SU; Jin LI; Wenjun DENG; Yazhou ZHANG

doi:10.12259/j.issn.2095-610X.S20240804

Volume 45 Issue 8

Aug. 2024

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Rui LI, Jianpei SU, Jin LI, Wenjun DENG, Yazhou ZHANG. A Mendelian Randomization Study on Alzheimer’ s Disease and Sarcopenia[J]. Journal of Kunming Medical University, 2024, 45(8): 24-29. doi: 10.12259/j.issn.2095-610X.S20240804

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Rui LI, Jianpei SU, Jin LI, Wenjun DENG, Yazhou ZHANG. A Mendelian Randomization Study on Alzheimer’ s Disease and Sarcopenia[J]. Journal of Kunming Medical University, 2024, 45(8): 24-29. doi: 10.12259/j.issn.2095-610X.S20240804

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A Mendelian Randomization Study on Alzheimer’ s Disease and Sarcopenia

doi: 10.12259/j.issn.2095-610X.S20240804

1.
Dept. of Geriatrics，2nd People’s Hospital of Kunming，Kunming Yunnan 650204
2.
Dept. of Geriatric Gastroenterology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2024-02-17
Available Online: 2024-07-06
Publish Date: 2024-08-05

Abstract

Abstract

Objective To explore the causal relationship between Alzheimer’ s disease and sarcopenia. Methods This study is based on three related phenotypes of Alzheimer's disease and sarcopenia in the public genome-wide association analysis （GWAS） database, namely, appendicular lean mass, walking speed, and low grip strength. Two-sample Mendelian randomization analysis was conducted using inverse variance weighting method, median weighting method, MR-Egger regression, etc., and sensitivity analysis was performed, including heterogeneity testing and multiple effect analysis. Results The MR analyses demonstrated that Alzheimer’ s disease may increase the risk of reduced appendicular lean mass （β = 0.010 , 95% confidence interval （CI） = 0.001～0.018, P = 0.021）, while Alzheimer’ s disease was a significantly correlated with low walking speed （β = 0.009, 95% confidence interval （CI） = 0.003～0.016, P = 0.005）. Conclusion Alzheimer’ s disease may increases the risk of sarcopenia.
- Mendelian randomization,
- Alzheimer’ s disease,
- Sarcopenia

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References(32)

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