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Citation: Rui LI, Jianpei SU, Jin LI, Wenjun DENG, Yazhou ZHANG. A Mendelian Randomization Study on Alzheimer’ s Disease and Sarcopenia[J]. Journal of Kunming Medical University, 2024, 45(8): 24-29. doi: 10.12259/j.issn.2095-610X.S20240804

A Mendelian Randomization Study on Alzheimer’ s Disease and Sarcopenia

doi: 10.12259/j.issn.2095-610X.S20240804
  • Received Date: 2024-02-17
    Available Online: 2024-07-06
  • Publish Date: 2024-08-05
  •   Objective  To explore the causal relationship between Alzheimer’ s disease and sarcopenia.   Methods  This study is based on three related phenotypes of Alzheimer's disease and sarcopenia in the public genome-wide association analysis (GWAS) database, namely, appendicular lean mass, walking speed, and low grip strength. Two-sample Mendelian randomization analysis was conducted using inverse variance weighting method, median weighting method, MR-Egger regression, etc., and sensitivity analysis was performed, including heterogeneity testing and multiple effect analysis.  Results  The MR analyses demonstrated that Alzheimer’ s disease may increase the risk of reduced appendicular lean mass (β = 0.010 , 95% confidence interval (CI) = 0.001~0.018, P = 0.021), while Alzheimer’ s disease was a significantly correlated with low walking speed (β = 0.009, 95% confidence interval (CI) = 0.003~0.016, P = 0.005).   Conclusion  Alzheimer’ s disease may increases the risk of sarcopenia.
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