Factors Affecting Serum HCG Levels on the Next Day of HCG Trigger and Its Relationship with Clinical Outcomes

Chunrong JIANG; Yushi MENG; Lijuan LI; Shuangyong BAI; lina ZHAO; Lan MA

doi:10.12259/j.issn.2095-610X.S20240811

Volume 45 Issue 8

Aug. 2024

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Chunrong JIANG, Yushi MENG, Lijuan LI, Shuangyong BAI, lina ZHAO, Lan MA. Factors Affecting Serum HCG Levels on the Next Day of HCG Trigger and Its Relationship with Clinical Outcomes[J]. Journal of Kunming Medical University, 2024, 45(8): 74-78. doi: 10.12259/j.issn.2095-610X.S20240811

Citation:

Chunrong JIANG, Yushi MENG, Lijuan LI, Shuangyong BAI, lina ZHAO, Lan MA. Factors Affecting Serum HCG Levels on the Next Day of HCG Trigger and Its Relationship with Clinical Outcomes[J]. Journal of Kunming Medical University, 2024, 45(8): 74-78. doi: 10.12259/j.issn.2095-610X.S20240811

Citation:

Chunrong JIANG, Yushi MENG, Lijuan LI, Shuangyong BAI, lina ZHAO, Lan MA. Factors Affecting Serum HCG Levels on the Next Day of HCG Trigger and Its Relationship with Clinical Outcomes[J]. Journal of Kunming Medical University, 2024, 45(8): 74-78. doi: 10.12259/j.issn.2095-610X.S20240811

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Factors Affecting Serum HCG Levels on the Next Day of HCG Trigger and Its Relationship with Clinical Outcomes

doi: 10.12259/j.issn.2095-610X.S20240811

1.
Reproductive Genetic Center，The 1st People’s Hospital of Kunming，Kunming Yunnan 650051
2.
Dept. of Reproductive Medicine，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2023-12-05
Available Online: 2024-07-06
Publish Date: 2024-08-05

Abstract

Abstract

Objective To investigate the influencing factors of serum HCG levels on the next day of human chorionic gonadotropin （HCG） trigger during in vitro fertilization-embryo transfer （IVF-ET） and its relationship with clinical outcomes. Methods A retrospective analysis was conducted on the data of 253 infertile patients who underwent IVF-ET fertility assistance at the Reproductive Genetics Center of the First People's Hospital in Kunming from January 2020 to December 2022. Patients were divided into 4 groups based on the serum HCG levels on the trigger day: Group A: HCG <50 IU/L with 8 cases; Group B: 50 IU/L ≤ HCG <100 IU/L with 73 cases; Group C: 100 IU/L ≤ HCG <150 IU/L with 90 cases; Group D: HCG ≥150 IU/L with 82 cases. The analysis included the impact of body mass index （BMI）, estradiol level on the trigger day, effect of number of follicles with a diameter ≥14 mm on the trigger day on the serum HCG level on the trigger day, and the relationship between the high and low levels of serum HCG on the trigger day and the clinical outcomes. Results There were statistically significant differences in BMI among the groups（P < 0.05）. The linear regression coefficient between BMI and serum HCG levels on the next day of trigger was-11.896（P < 0.05）, showing a significant negative correlation. There were statistically significant differences in oocyte retrieval rate, Meiosis II （MII） oocyte rate and normal fertilization rate among the four groups（P < 0.05）. There was no significant difference in other observed indicators（P > 0.05）, but there was an increasing trend in the rates of high-quality embryos, embryo implantation, and clinical pregnancy with increasing HCG levels. Conclusion The serum HCG levels of the day after trigger have a significant effect on the oocyte retrieval rate, MII oocyte rate and normal fertilization rate potentially affecting the high-quality embryo rate, clinical pregnancy rate and embryo implantation rate. BMI is an important factor affecting the serum HCG levels on the day after trigger, and the dosage of HCG trigger should be personalized based on BMI levels.
- Trigger,
- HCG levels,
- Body mass index,
- Clinical outcomes

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