Factors Affecting Serum HCG Levels on the Next Day of HCG Trigger and Its Relationship with Clinical Outcomes

Chunrong JIANG; Yushi MENG; Lijuan LI; Shuangyong BAI; lina ZHAO; Lan MA

doi:10.12259/j.issn.2095-610X.S20240811

Volume 45 Issue 8

Aug. 2024

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Chunrong JIANG, Yushi MENG, Lijuan LI, Shuangyong BAI, lina ZHAO, Lan MA. Factors Affecting Serum HCG Levels on the Next Day of HCG Trigger and Its Relationship with Clinical Outcomes[J]. Journal of Kunming Medical University, 2024, 45(8): 74-78. doi: 10.12259/j.issn.2095-610X.S20240811

Citation:

Chunrong JIANG, Yushi MENG, Lijuan LI, Shuangyong BAI, lina ZHAO, Lan MA. Factors Affecting Serum HCG Levels on the Next Day of HCG Trigger and Its Relationship with Clinical Outcomes[J]. Journal of Kunming Medical University, 2024, 45(8): 74-78. doi: 10.12259/j.issn.2095-610X.S20240811

Citation:

Chunrong JIANG, Yushi MENG, Lijuan LI, Shuangyong BAI, lina ZHAO, Lan MA. Factors Affecting Serum HCG Levels on the Next Day of HCG Trigger and Its Relationship with Clinical Outcomes[J]. Journal of Kunming Medical University, 2024, 45(8): 74-78. doi: 10.12259/j.issn.2095-610X.S20240811

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Factors Affecting Serum HCG Levels on the Next Day of HCG Trigger and Its Relationship with Clinical Outcomes

doi: 10.12259/j.issn.2095-610X.S20240811

1.
Reproductive Genetic Center，The 1st People’s Hospital of Kunming，Kunming Yunnan 650051
2.
Dept. of Reproductive Medicine，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2023-12-05
Available Online: 2024-07-06
Publish Date: 2024-08-05

Abstract

Abstract

Objective To investigate the influencing factors of serum HCG levels on the next day of human chorionic gonadotropin （HCG） trigger during in vitro fertilization-embryo transfer （IVF-ET） and its relationship with clinical outcomes. Methods A retrospective analysis was conducted on the data of 253 infertile patients who underwent IVF-ET fertility assistance at the Reproductive Genetics Center of the First People's Hospital in Kunming from January 2020 to December 2022. Patients were divided into 4 groups based on the serum HCG levels on the trigger day: Group A: HCG <50 IU/L with 8 cases; Group B: 50 IU/L ≤ HCG <100 IU/L with 73 cases; Group C: 100 IU/L ≤ HCG <150 IU/L with 90 cases; Group D: HCG ≥150 IU/L with 82 cases. The analysis included the impact of body mass index （BMI）, estradiol level on the trigger day, effect of number of follicles with a diameter ≥14 mm on the trigger day on the serum HCG level on the trigger day, and the relationship between the high and low levels of serum HCG on the trigger day and the clinical outcomes. Results There were statistically significant differences in BMI among the groups（P < 0.05）. The linear regression coefficient between BMI and serum HCG levels on the next day of trigger was-11.896（P < 0.05）, showing a significant negative correlation. There were statistically significant differences in oocyte retrieval rate, Meiosis II （MII） oocyte rate and normal fertilization rate among the four groups（P < 0.05）. There was no significant difference in other observed indicators（P > 0.05）, but there was an increasing trend in the rates of high-quality embryos, embryo implantation, and clinical pregnancy with increasing HCG levels. Conclusion The serum HCG levels of the day after trigger have a significant effect on the oocyte retrieval rate, MII oocyte rate and normal fertilization rate potentially affecting the high-quality embryo rate, clinical pregnancy rate and embryo implantation rate. BMI is an important factor affecting the serum HCG levels on the day after trigger, and the dosage of HCG trigger should be personalized based on BMI levels.
- Trigger,
- HCG levels,
- Body mass index,
- Clinical outcomes

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References(21)

References

[1]	Dosouto C,Haahr T,Humaidan P. Advances in ovulation trigger strategies[J]. Panminerva Med,2019,61(1):42-51.
[2]	郑明明,魏超峰,连方. 空卵泡综合征的最新研究进展[J]. 中国生育健康志,2022,33(1):74-77.
[3]	伍春蓉,冯兰青,黄惠英,等. IVF长方案促排周期HCG扳机次日血清β-HCG水平与临床结局的关系[J]. 现代医院,2020,20(1):143-146,150.
[4]	Alviggi C,Andersen C Y,Buehler K,et al. A new more detailed stratification of low responders to ovarian stimulation: From a poor ovarian response to a low prognosis concept[J]. Fertility and Sterility,2016,105(6):1452-1453. doi: 10.1016/j.fertnstert.2016.02.005
[5]	子宫腺肌病伴不孕症诊疗中国专家共识编写组. 子宫腺肌病伴不孕症诊疗中国专家共识[J]. 中华生殖与避孕杂志,2021,41(4):287-295.
[6]	张颐,张师前,邓雷,等. 输卵管积水相关不孕症诊治中国专家共识(2023年版)[J]. 中国实用妇科与产科杂志,2023,39(10):1009-1016.
[7]	李九凤,谭美华. 卵泡期长方案和常规长方案在首次IVF/ICSI治疗的卵巢储备良好患者中的应用[J]. 妇产与遗传(电子版),2021,11(3):15-19.
[8]	Noorhasan D J,McGovern P G,Cho M,et al. Serum HCG levels following the ovulatory injection: Associations with patient weight and implantation time[J]. Obstetrics and Gynecology International,2015,2015:520714.
[9]	吴惠华,孟庆霞,丁洁,等. HCG扳机后血清HCG水平对IVF结局的影响[J]. 生殖医学杂志,2021,30(3):331-336.
[10]	张希奇,杨美琼. 不同剂量HCG控制性促排卵诱导卵泡成熟及对胚胎移植妊娠结局影响[J]. 中国计划生育学杂志,2020,28(12):2045-2048.
[11]	彭兆锋,孙莹璞,王芳,等. 控制性超排卵注射hCG后血清β-hCG水平与体质量指数的关系[J]. 生殖与避孕,2010,30(5):321-324.
[12]	赵培娟,谭丽,齐越凡,等. 获卵困难患者补充肌注hCG的临床效果研究[J]. 中国计划生育和妇产科,2022,14(2):65-68,79.
[13]	Richani D,Gilchrist R B. The epidermal growth factor network: Role in oocyte growth,maturation and developmental competence[J]. Human Reproduction Update,2018,24(1):1-14. doi: 10.1093/humupd/dmx029
[14]	石雪冬,张娜,甄秀丽,等. 扳机后12~13h血清人绒毛膜促性腺激素水平对体外受精结局的影响[J]. 山东医药,2020,60(2):49-51.
[15]	安欣裕,张学红. 2种补救注射hCG扳机方案治疗假性空卵泡综合征1例[J]. 中国计划生育和妇产科,2023,15(9):105-108.
[16]	李彦奇,张坤,孙健. 一例卵母细胞成熟障碍综合征的分析报告[J]. 新疆医学,2019,49(3):323-324.
[17]	张红,唐奕,罗克莉,等. 空卵泡综合征71例临床分析[J]. 生殖医学杂志,2014,23(10):834-837.
[18]	Mizrachi Y,Horowitz E,Farhi J,et al. Human chorionic gonadotropin serum levels following ovulation triggering and IVF cycle outcome[J]. Journal of Assisted Reproduction and Genetics,2018,35(5):891-897. doi: 10.1007/s10815-018-1165-x
[19]	袁丽娜,韩莹,王昕妍,等. 扳机后血清hCG浓度与获卵率及其他体外受精参数的相关性[J]. 江苏医药,2022,48(4):402-406.
[20]	Coleson M P,Sanchez N S,Ashley A K,et al. Human chorionic gonadotropin increases serum progesterone,number of corpora lutea and angiogenic factors in pregnant sheep[J]. Reproduction,2015,150(1):43-52. doi: 10.1530/REP-14-0632
[21]	Zhou J,Wang S,Wang B,et al. The value of HCG serum concen-trations after trigger in predicting pregnancy and live birth rates in IVF-ICSI[J]. Reprod Bio Med Online,2015,30(6):667-673. doi: 10.1016/j.rbmo.2015.02.013

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