Expression of ANXA8，PGRMC1，and miR-92a in Cervical Cancer and Their Relationship with Clinicopathological Features

Zhibo MIN; Ran ZHOU; Dan PU; Tao YANG

doi:10.12259/j.issn.2095-610X.S20240815

Volume 45 Issue 8

Aug. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(8): 101-108

Zhibo MIN, Ran ZHOU, Dan PU, Tao YANG. Expression of ANXA8，PGRMC1，and miR-92a in Cervical Cancer and Their Relationship with Clinicopathological Features[J]. Journal of Kunming Medical University, 2024, 45(8): 101-108. doi: 10.12259/j.issn.2095-610X.S20240815

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Zhibo MIN, Ran ZHOU, Dan PU, Tao YANG. Expression of ANXA8，PGRMC1，and miR-92a in Cervical Cancer and Their Relationship with Clinicopathological Features[J]. Journal of Kunming Medical University, 2024, 45(8): 101-108. doi: 10.12259/j.issn.2095-610X.S20240815

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Expression of ANXA8，PGRMC1，and miR-92a in Cervical Cancer and Their Relationship with Clinicopathological Features

doi: 10.12259/j.issn.2095-610X.S20240815

Dept. of Pathology，The 2nd People’s Hospital of Yibin，Yibin Sichuan 644000，China

Received Date: 2024-04-11
Available Online: 2024-07-05
Publish Date: 2024-08-05

Abstract

Abstract

Objective To investigate the expression of ANXA8, PGRMC1, and miR-92a in cervical cancer tissues and their relationship with clinicopathological features. Methods A total of 69 cervical cancer patients treated at the Second People’ s Hospital of Yibin City from January 2020 to March 2022 were included in this study. Cervical cancer tissues and adjacent normal tissues from these patients were collected for analysis. Immunohistochemistry was used to detect the positivity of ANXA8 and PGRMC1. Western blot was performed to analyze the protein expression of ANXA8 and PGRMC1. RT-PCR was used to measure the mRNA levels of ANXA8 and PGRMC1, as well as the expression level of miR-92a.The linear correlation among ANXA8, PGRMC1, and miR-92a expression levels, as well as their relationships with the clinical pathological features of cervical cancer patients, were analyzed. Results The positive rates of ANXA8 and PGRMC1 in cervical cancer tissues （76.81%, 72.46%） were significantly higher than adjacent tissues （4.35% and 7.25%）, and the expression level of miR-92a was significantly higher than adjacent tissues （P < 0.05）. With higher FIGO stage, lower differentiation degree, lymph node metastasis, and parametrial infiltration, the positivity rates of ANXA8 and PGRMC1 as well as the expression level of miR-92a were higher（P < 0.05）. Conclusion ANXA8, PGRMC1, and miR-92a are highly expressed in cervical cancer tissues, and are related to the pathological characteristics such as tumor staging, differentiation degree, metastasis, and invasion. They can provide a reliable basis for the pathological evaluation of cervical cancer patients.
- Cervical cancer,
- Annexin A8,
- Progesterone receptor membrane component 1,
- microRNA-92a,
- Clinicopathological features

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References(26)

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