Effect of Hybrid Blood Purification on Dialysis Adequacy，Immunity，and Inflammation in ESRD Patients with Inadequate Peritoneal Dialysis

Yibiao GUAN; Sheng HUANG; Libo LI

doi:10.12259/j.issn.2095-610X.S20240818

Volume 45 Issue 8

Aug. 2024

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Yibiao GUAN, Sheng HUANG, Libo LI. Effect of Hybrid Blood Purification on Dialysis Adequacy，Immunity，and Inflammation in ESRD Patients with Inadequate Peritoneal Dialysis[J]. Journal of Kunming Medical University, 2024, 45(8): 125-132. doi: 10.12259/j.issn.2095-610X.S20240818

Citation:

Yibiao GUAN, Sheng HUANG, Libo LI. Effect of Hybrid Blood Purification on Dialysis Adequacy，Immunity，and Inflammation in ESRD Patients with Inadequate Peritoneal Dialysis[J]. Journal of Kunming Medical University, 2024, 45(8): 125-132. doi: 10.12259/j.issn.2095-610X.S20240818

Citation:

Yibiao GUAN, Sheng HUANG, Libo LI. Effect of Hybrid Blood Purification on Dialysis Adequacy，Immunity，and Inflammation in ESRD Patients with Inadequate Peritoneal Dialysis[J]. Journal of Kunming Medical University, 2024, 45(8): 125-132. doi: 10.12259/j.issn.2095-610X.S20240818

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Effect of Hybrid Blood Purification on Dialysis Adequacy，Immunity，and Inflammation in ESRD Patients with Inadequate Peritoneal Dialysis

doi: 10.12259/j.issn.2095-610X.S20240818

Dept. of Nephrology，Nanhai District People’s Hospital，Foshan Guangdong 528200，China

Received Date: 2023-11-24
Available Online: 2024-07-06
Publish Date: 2024-08-25

Abstract

Abstract

Objective To explore the application of hybrid blood purification in patients with end-stage renal disease （ESRD） with inadequate peritoneal dialysis, and its effects on dialysis adequacy, chronic inflammation status, and safety improvement. Methods 80 patients with inadequate peritoneal dialysis （ESRD） in Foshan Nanhai District People's Hospital from September 2020 to August 2022 were selected and randomly divided into two groups, with 40 cases in each group. The control group received simple hemodialysis, while the observation group received hybrid blood purification continuously for 3 months. A comparison was made between the general data of the two groups, serum indicators before and after treatment [intact parathyroid hormone （iPTH）, β2-microglobulin （β2-MG）, cystatin C （CysC）], renal function indicators [blood urea nitrogen （BUN）, serum creatinine （Scr）, residual renal function （RRF）], nutritional status [hemoglobin （Hb）, albumin （Alb）, transferrin （TRF）], chronic inflammatory status [interleukin-6 （IL-6）, high-sensitivity C-reactive protein （hs-CRP）, tumor necrosis factor-alpha （TNF-α）], red blood cell immune function [red blood cell immune complex ring rate （RBC-ICR）, red blood cell C3b receptor （RBC-C3bR）, CD35-positive red blood cell percentage] and urea clearance index （KT/V）, as well as the incidence of complications. Results After 1 and 3 months of treatment, the levels of iPTH, β2-MG and CysC in the observation group were lower than those in the control group, and KT/V was higher than that in the control group （P < 0.05）; after 1 and 3 months of treatment, BUN, Scr, RRF levels were lower than those in the control group （P < 0.05）; after 1 and 3 months of treatment, the levels of Hb, Alb, and TRF in the observation group were higher than those in the control group, and the levels of IL-6, hs-CRP, and TNF-α were lower than those in the control group （ P < 0.05）; after 1 and 3 months of treatment, the percentage of CD35-positive red blood cells and RBC-C3bR level in the observation group were higher than those in the control group, and the RBC-ICR level was lower than that in the control group （P < 0.05）; the incidence of complications in the observation group was 7.50% Compared with 20.00% in the control group, the difference was not statistically significant （P > 0.05）. Conclusion Hybrid blood purification utilizes the principles of diffusion, convection, and adsorption to maximize the removal of inflammatory mediators, improve dialysis adequacy and red blood cell immune adhesion activity, enhance body nutritional status and renal function. This approach has shown significant effectiveness in ESRD patients with inadequate dialysis.
- Hybrid blood purification,
- Dialysis adequacy,
- End-stage renal disease,
- Chronic inflammation,
- Safety

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