Toxicity Differences of Amanita Manginiana in Seven Villiages in Yunnan Province

Baining QIU; Yuebing WANG; Wu LONG; Sijie WEI; Rui WANG; Lin MA; Yanmei XI; Xue TANG; Puping LEI

doi:10.12259/j.issn.2095-610X.S20240821

Volume 45 Issue 8

Aug. 2024

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2024 > 45(8): 145-153

Baining QIU, Yuebing WANG, Wu LONG, Sijie WEI, Rui WANG, Lin MA, Yanmei XI, Xue TANG, Puping LEI. Toxicity Differences of Amanita Manginiana in Seven Villiages in Yunnan Province[J]. Journal of Kunming Medical University, 2024, 45(8): 145-153. doi: 10.12259/j.issn.2095-610X.S20240821

Citation:

Baining QIU, Yuebing WANG, Wu LONG, Sijie WEI, Rui WANG, Lin MA, Yanmei XI, Xue TANG, Puping LEI. Toxicity Differences of Amanita Manginiana in Seven Villiages in Yunnan Province[J]. Journal of Kunming Medical University, 2024, 45(8): 145-153. doi: 10.12259/j.issn.2095-610X.S20240821

Citation:

Baining QIU, Yuebing WANG, Wu LONG, Sijie WEI, Rui WANG, Lin MA, Yanmei XI, Xue TANG, Puping LEI. Toxicity Differences of Amanita Manginiana in Seven Villiages in Yunnan Province[J]. Journal of Kunming Medical University, 2024, 45(8): 145-153. doi: 10.12259/j.issn.2095-610X.S20240821

PDF( 5423 KB)

Toxicity Differences of Amanita Manginiana in Seven Villiages in Yunnan Province

doi: 10.12259/j.issn.2095-610X.S20240821

1.
Faculty of Forensic Medicine，Kunming Medical University，Kunming Yunnan 650500
2.
Yunnan Provincial Endemic Disease Control and Prevention Institute，Dali Yunnan 671000，China

Received Date: 2024-04-12
Available Online: 2024-07-05
Publish Date: 2024-08-25

Abstract

Abstract

Objective Compare the toxic effects of Amanita Manginiana from seven different regions in Yunnan Province on the livers and kidneys of mice. Methods The Kunming mice were randomly divided into 7 groups, each subgrouped into 6 h, 3 d, 7 d, and 14 d time points, with 5 mice in each time group. The experiment involved gastric lavage using Yunnan's Amanita Manginiana from 7 villages from different counties, with the control group （0 h） receiving an equivalent amount of saline lavage. Blood samples were taken from the eyes at different time points after each lavage to measure levels of alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, and uric acid （UA） in the serum. The mice's liver and kidney weights were measured, their liver and kidney indices determined, and liver and kidney tissues were observed using HE staining. Results The Amanita Manginiana from Yuding Village, Mouding County （MDYD）, and Yongcui Village, Luquan County （LQYC）, caused acute damage to the livers and kidneys of mice. Within 6 hours of gavage, the mice's serum biochemical indicators began to rise, peaking on the 7th day, and started to decline by the 14th day, indicating a trend towards recovery of the damage （P < 0.05）. However, the Amanita Manginiana from Donghua Village, Tengchong City （TCDH）, and Yongcui Village, Luquan County （LQYC）, only damaged the livers of mice. Even after the 14th day, the levels of AST, ALT, and UA in the serum continued to rise, indicating a longer-lasting impact of the local Amanita Manginiana on the liver （P < 0.05）. The Amanita Manginiana from Moguang Village, Heqing County （HQMG）, Dean Village, Nanjian County （NJDA）, and Gaoping Village, Mouding County （MDGP）, caused damage to both the livers and kidneys of mice. After the 14th day, the levels of AST, ALT, and UA in the serum continued to increase （P < 0.05）, showing that the damage to the mice's liver and kidneys did not improve. Conclusion Amanita Manginiana from different villages in Yunnan Province contains varying levels of liver and kidney toxicity, posing a potential risk to the liver and kidneys. It is advisable to exercise caution when consuming Amanita Manginiana.
- Amanita manginiana,
- Hepatotoxicity,
- Renal toxicity,
- Yunnan

FullText(HTML)

References(24)

References

[1]	杨祝良. 试谈我国鹅膏菌的分类研究[J]. 菌物系统,2000,19(3):435-440.
[2]	杨祝良. 我国的几种剧毒鹅膏菌[J]. 中国食用菌,2002,21(3):17-18. doi: 10.3969/j.issn.1003-8310.2002.03.009
[3]	Berger K J,Guss D A. Mycotoxins revisited: Part II[J]. J Emerg Med,2005,28(2):175-183. doi: 10.1016/j.jemermed.2004.08.019
[4]	董国日,张志光,陈作红. 鹅膏菌毒素及其毒理研究进展[J]. 生物学杂志,2000,17(3):1-3. doi: 10.3969/j.issn.2095-1736.2000.03.001
[5]	颜芝闻,吴晓旻,裴红兵,等. 武汉市一起毒蘑菇中毒事件现场调查和鉴定[J]. 中国食品卫生杂志,2020,32(5):566-569.
[6]	李海蛟,章轶哲,刘志涛,等. 云南蘑菇中毒事件中的毒蘑菇物种多样性[J]. 菌物学报,2022,41(9):1416-1429.
[7]	杜进良,瞿鹏飞,李玉华,等. 云南不明原因猝死地区隐花青鹅膏的毒性研究[J]. 中国法医学杂志,2022,37(1):54-59.
[8]	何永旺,赵祥月,贾彭林,等. 云南不明原因猝死研究进展[J]. 法医学杂志,2017,33(5):470-475. doi: 10.3969/j.issn.1004-5619.2017.05.003
[9]	陈丽,邢琴,周忠志,等. 复方ANBP对小鼠创面组织学变化的实验研究[J]. 湖南中医药大学学报,2019,39(6):699-703. doi: 10.3969/j.issn.1674-070X.2019.06.005
[10]	Nair A,Morsy M A,Jacob S. Dose translation between laboratory animals and human in preclinical and clinical phases of drug development[J]. Drug Dev Res,2018,79(8):373-382. doi: 10.1002/ddr.21461
[11]	黄娜娜,郭欣,蔡涛涛,等. 决明子不同提取物单次给药对小鼠肝、肾“量-时-毒”关系研究[J]. 中国药物警戒,2017,14(10):594-598. doi: 10.3969/j.issn.1672-8629.2017.10.005
[12]	Ming L,Qi B,Hao S,et al. Camel milk ameliorates inflammatory mechanisms in an alcohol-induced liver injury mouse model[J]. Sci Rep,2021,11(1):22811. doi: 10.1038/s41598-021-02357-1
[13]	陈瑜鑫,李瑶,高海云,等. 鹅膏菌毒性成分中毒特征及开发应用研究进展[J]. 中国药物警戒,2024,21(5):496-501.
[14]	Hu W,Li Z,Wang W,et al. Structural characterization of polysaccharide purified from Amanita caesarea and its pharmacological basis for application in Alzheimer’s disease: Endoplasmic reticulum stress[J]. Food Funct,2021,12(21):11009-11023. doi: 10.1039/D1FO01963E
[15]	Sun L,Liu Q,Bao C,et al. Comparison of free total amino acid compositions and their functional classifications in 13 wild edible mushrooms[J]. Molecules,2017,22(3):350 doi: 10.3390/molecules22030350
[16]	Surayot U,Wangtueai S,You S,et al. Sulphation and hydrolysis improvements of bioactivities,and immuno-modulatory properties of edible amanita hemibapha subspecies javanica (corner and bas) mucilage polysaccharide as a potential in personalized functional foods[J]. J Fungi (Basel),2021,7(10):847. doi: 10.3390/jof7100847
[17]	张慧,陈蕊,陈霞,等. 世界野生食用菌产业经济发展研究概述[J]. 经济研究导刊,2014(28):59-61,75. doi: 10.3969/j.issn.1673-291X.2014.28.023
[18]	卯晓岚. 中国毒菌物种多样性及其毒素[J]. 菌物学报,2006,25(3):345-363. doi: 10.3969/j.issn.1672-6472.2006.03.004
[19]	母华强,陈艳. 珠海城区臭鼩身体大小和脏器指数的性别及季节差异[J]. 野生动物学报,2022,43(2):386-393. doi: 10.12375/ysdwxb.20220212
[20]	王磊,赵鹏. 拉米夫定联合恩替卡韦对乙型肝炎患者肝功能及Th1/Th2类细胞因子的影响[J]. 检验医学与临床,2019,16(15):2226-2228. doi: 10.3969/j.issn.1672-9455.2019.15.037
[21]	王如萍,刘梦姣,田梦新,等. 败酱草对小鼠急性酒精性肝损伤作用的研究[J]. 中医临床研究,2023,15(20):137-142. doi: 10.3969/j.issn.1674-7860.2023.20.027
[22]	苗志敏,赵世华,王颜刚,等. 山东沿海居民高尿酸血症及痛风的流行病学调查[J]. 中华内分泌代谢杂志,2006,22(5):421-425. doi: 10.3760/j.issn:1000-6699.2006.05.005
[23]	Danese E,Montagnana M. An historical approach to the diagnostic biomarkers of acute coronary syndrome[J]. Ann Transl Med,2016,4(10):194. doi: 10.21037/atm.2016.05.19
[24]	龙武,瞿鹏飞,马琳,等. 一起云南不明原因猝死案件中4种野生菌的细胞毒性[J]. 法医学杂志,2023,39(2):121-128.

Relative Articles(20)

Relative Articles

[1]	Hai ZHOU, Zhongqin YUAN, Yongcun CEN, Yanni LU, Zhihong YAO, Yongchun ZHOU, Yunchao HUANG. Survival Analysis of 1635 Patients with Esophageal Cancer: A Single-Center Retrospective Study. Journal of Kunming Medical University, 2024, 45(8): 67-73. doi: 10.12259/j.issn.2095-610X.S20240810
[2]	Yue XU, Chan WANG, Shucheng LIN, Huijie ZHANG, Yi TAN, Shuwei ZHANG, Xiaofeng ZENG, Zhen LI. Advances in the Mechanism of Hepatotoxic Effects Induced by α-amanitin. Journal of Kunming Medical University, 2022, 43(12): 153-158. doi: 10.12259/j.issn.2095-610X.S20221228
[3]	Yuan-yuan LI, Juan LI, Gen-meng YANG, Jian HUANG, Liu LIU, Bao-yu SHEN, Chan WANG, Yue XU, Shu-cheng LIN, Xiao-feng ZENG. Research Progress on Neurotoxic Effects and Mechanism of Methamphetamine. Journal of Kunming Medical University, 2021, 42(2): 153-157. doi: 10.12259/j.issn.2095-610X.S20210210
[4]	Sheng-hao LI, Jie DING, Qing-qing WANG, Si-qi LIU, Li-juan HUA, Jin-yu DUAN, Bao-li BO, An-rui DU, Guo-ji CHANG, Jun-yi LI. Influencing Factors of Moderate to Severe Liver Injury in Patients with Chronic Hepatitis B and NAFLD. Journal of Kunming Medical University, 2021, 42(7): 77-82. doi: 10.12259/j.issn.2095-610X.S20210712
[5]	Zhu Xing Lei , Zhang Ling . . Journal of Kunming Medical University, 2020, 41(05): 13-17.
[6]	Lv Song Qin , Huang Shan , Li Xiao Fei , Shi Jin Li , Li Guang Min , Duan Hong Fen . Application of T-lymphocyte Subsets for Non-viral Liver Disease. Journal of Kunming Medical University, 2019, 40(03): 107-111.
[7]	Zhang Le , Tang Li Bin , Jiang Jian Jie , Xia Jia Wei , Lv Zheng Xuan , Li Yun Zhen , Han Liu Xin , Bai Bin . 非生物型人工肝技术治疗肝衰竭合并肝肾综合征. Journal of Kunming Medical University, 2017, 38(06): 36-39.
[8]	Zhang Lan Chun , Wang Shang Wen , Hu Wei Yan , Zhao Rong Hua , Yu Hao Fei , Zhang Rong Ping . Protective Effects of Rosemary's Extract on Cerebral Ischemia in Mice and Acute Toxicity Evaluation. Journal of Kunming Medical University, 2016, 37(12): 16-19.
[9]	Sun Yue , Wei Jia , Lu Yong Ping , Wang Jin , Zou Yu , Wang Yu Xue , Yang Mi . Quantitative Analysis on Staging of Chronic Viral Hepatitis B and Hepatic Fibrosis by Real-time Shear Wave Elastography. Journal of Kunming Medical University, 2016, 37(11): 55-59.
[10]	Zhao Jing Yun . . Journal of Kunming Medical University,
[11]	Wang Xiao . . Journal of Kunming Medical University,
[12]	Bian Hai Xia . . Journal of Kunming Medical University,
[13]	Ma Yan Li . . Journal of Kunming Medical University,
[14]	Li Yan . . Journal of Kunming Medical University,
[15]	Wei Dan Xia . . Journal of Kunming Medical University,
[16]	Yan Jun . . Journal of Kunming Medical University,
[17]	Liu Ju Peng . . Journal of Kunming Medical University,
[18]	Liu Ru Wen . . Journal of Kunming Medical University,
[19]	Ma Qiang . . Journal of Kunming Medical University,
[20]	. . Journal of Kunming Medical University,