Correlation between 24-hour Urinary Sodium Excretion，IL-18 Level and Urinary Albumin in Patients with Type 2 Diabetes Mellitus

Longqiao TAN; Li SHI; Jianfang LIU; Xuemei XIA; Li ZHU; Yushan XU

doi:10.12259/j.issn.2095-610X.S20240908

Volume 45 Issue 9

Sep. 2024

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Longqiao TAN, Li SHI, Jianfang LIU, Xuemei XIA, Li ZHU, Yushan XU. Correlation between 24-hour Urinary Sodium Excretion，IL-18 Level and Urinary Albumin in Patients with Type 2 Diabetes Mellitus[J]. Journal of Kunming Medical University, 2024, 45(9): 49-55. doi: 10.12259/j.issn.2095-610X.S20240908

Citation:

Longqiao TAN, Li SHI, Jianfang LIU, Xuemei XIA, Li ZHU, Yushan XU. Correlation between 24-hour Urinary Sodium Excretion，IL-18 Level and Urinary Albumin in Patients with Type 2 Diabetes Mellitus[J]. Journal of Kunming Medical University, 2024, 45(9): 49-55. doi: 10.12259/j.issn.2095-610X.S20240908

Citation:

Longqiao TAN, Li SHI, Jianfang LIU, Xuemei XIA, Li ZHU, Yushan XU. Correlation between 24-hour Urinary Sodium Excretion，IL-18 Level and Urinary Albumin in Patients with Type 2 Diabetes Mellitus[J]. Journal of Kunming Medical University, 2024, 45(9): 49-55. doi: 10.12259/j.issn.2095-610X.S20240908

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Correlation between 24-hour Urinary Sodium Excretion，IL-18 Level and Urinary Albumin in Patients with Type 2 Diabetes Mellitus

doi: 10.12259/j.issn.2095-610X.S20240908

Longqiao TAN^{1, 2},
Li SHI¹,
Jianfang LIU¹,
Xuemei XIA¹,
Li ZHU¹,
Yushan XU^{1
,
,}

1.
Dept. of Endocrinology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Dept. of Endocrinology，Kunming Second People’s Hospital，Kunming Yunnan 650201，China

Received Date: 2024-05-10
Available Online: 2024-09-01
Publish Date: 2024-09-25

Abstract

Abstract

Objective To evaluate the effects of different sodium intake levels and serum inflammatory factors on the risk of urinary albumin （UA） in patients with type 2 diabetes mellitus （T2DM） by using 24 h UNa as an indicator of sodium intake. Methods 130 T2DM patients were included and divided into a UA-positive group （60 cases） and a UA-negative group （70 cases） according to urinary albumin/creatinine ratio （UACR）. Clinical data of patients were collected and inflammatory factors and 24-hour urine-related indexes were detected. spearman correlation analysis was used to analyze the correlation between clinical indicators and UACR in T2DM patients. The effect of clinical indicators on UA in T2DM patients was analyzed by binary Logistic regression. The effect of 24 h UNa and IL-18 correlation on UA was analyzed by binary regression method. Results 24 h UNa level （OR = 1.019, 95%CI 1.003～1.035, P = 0.017）and IL-18 （OR = 1.204, 95%CI1.060～1.368, P = 0.004）were independent risk factors for positive UA in T2DM patients. Conjoint analysis suggested a significantly increased risk of UA positive in the high-sodium and high-IL-18 groups （OR = 10.774, 95%CI 2.105～55.155, P = 0.004）compared with the low-sodium and low-IL-18 groups. Conclusion Increased levels of 24 h UNa and IL-18 are risk factors for UA in T2DM patients.
- Type 2 diabetes mellitus,
- Urinary albumin,
- 24 h Urinary sodium excretion,
- IL-18

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References(27)

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