Prevalence and Influence Factors of Renal Function Impairment in Patients Following Radical Cystectomy：A Systematic Review and Meta-analysis

Qingmei YU; Tao SHI; Hongxue GUAN; Yujun MAO; Zhaoyi LI; Jiao YANG

doi:10.12259/j.issn.2095-610X.S20240913

Volume 45 Issue 9

Sep. 2024

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Qingmei YU, Tao SHI, Hongxue GUAN, Yujun MAO, Zhaoyi LI, Jiao YANG. Prevalence and Influence Factors of Renal Function Impairment in Patients Following Radical Cystectomy：A Systematic Review and Meta-analysis[J]. Journal of Kunming Medical University, 2024, 45(9): 83-90. doi: 10.12259/j.issn.2095-610X.S20240913

Citation:

Qingmei YU, Tao SHI, Hongxue GUAN, Yujun MAO, Zhaoyi LI, Jiao YANG. Prevalence and Influence Factors of Renal Function Impairment in Patients Following Radical Cystectomy：A Systematic Review and Meta-analysis[J]. Journal of Kunming Medical University, 2024, 45(9): 83-90. doi: 10.12259/j.issn.2095-610X.S20240913

Citation:

Qingmei YU, Tao SHI, Hongxue GUAN, Yujun MAO, Zhaoyi LI, Jiao YANG. Prevalence and Influence Factors of Renal Function Impairment in Patients Following Radical Cystectomy：A Systematic Review and Meta-analysis[J]. Journal of Kunming Medical University, 2024, 45(9): 83-90. doi: 10.12259/j.issn.2095-610X.S20240913

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Prevalence and Influence Factors of Renal Function Impairment in Patients Following Radical Cystectomy：A Systematic Review and Meta-analysis

doi: 10.12259/j.issn.2095-610X.S20240913

1.
Dept. of Urology
2.
Dept. of Nursing，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118，China

Received Date: 2024-04-27
Available Online: 2024-09-04
Publish Date: 2024-09-25

Abstract

Abstract

Objective To systematically evaluate the incidence and influencing factors of postoperative renal dysfunction in patients undergoing radical cystectomy. Methods The cohort studies and case-control studies related to postoperative renal function damage of patients undergoing radical cystectomy were retrieved from China HowNet, VIP, Wanfang, China Biomedical Literature Database, The Cochrane Library, PubMed, Web of Science and Embasedatabases. The retrieval time is from the establishment of the database to September 30, 2023. Two researchers independently conducted literature screening and article quality assessment based on predefined inclusion and exclusion criteria. Mata analysis was carried out on the literature with Stata14.0 software. Results A total of 11 articles were included. Meta-analysis showed that the heterogeneity of the included studies was large （I ² = 92.5%, P < 0.001）. Based on the random effect model, the incidence of renal function damage after radical cystectomy was 32%[95%CI （0.25, 0.35）, P < 0.001], and subgroup analysis showed that the research duration was 5 years or more 30%[95%CI （0.24, 0.37）, P < 0.001], the study area was Asia35%[95%CI （0.28, 0.42） in Asia, P < 0.001] , the postoperative estimated glomerular filtration rate was < 45 mL/（min·1.73m²） as the evaluation standard of renal function damage 33%[95%CI （0.29, 0.36）, P < 0.001]and cohort studies 39%[95%CI （0.26, 0.52）, P < 0.001]is higher. The influencing factors of postoperative renal dysfunction were age[HR = 1.03, 95%CI （1.02, 1.04）], hypertension [HR = 2.14, 95%CI （1.32, 3.40）], hydronephrosis [HR = 1.89, 95%CI （1.50, 2.36）], urinary tract infection[HR = 1.35, 95%CI （1.13, 1.61）] and Anastomotic stenosis [HR = 2.53, 95%CI （1.77, 3.61）]. Conclusion The incidence of renal function damage after radical cystectomy is high, which is closely related to age, history of hypertension, postoperative hydronephrosis, urinary tract infection and anastomotic stenosis. Medical staff should strengthen the monitoring of postoperative renal function and formulate effective measures for related influencing factors to reduce the incidence of renal function damage.
- Renal function damage,
- Radical cystectomy,
- Influencing factors,
- Systematic review,
- Meta analysis

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