Effect of PCV-VG Mode Combined with Dexmedetomidine on Intraoperative Respiratory Mechanics and Blood Gas Indicators in Patients Undergoing Laparoscopic Sleeve Gastrectomy

Hongmei BAO; Rong QIN; Yu ZHANG; Meiju YANG; Gang SU

doi:10.12259/j.issn.2095-610X.S20240917

Volume 45 Issue 9

Sep. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(9): 110-115

Hongmei BAO, Rong QIN, Yu ZHANG, Meiju YANG, Gang SU. Effect of PCV-VG Mode Combined with Dexmedetomidine on Intraoperative Respiratory Mechanics and Blood Gas Indicators in Patients Undergoing Laparoscopic Sleeve Gastrectomy[J]. Journal of Kunming Medical University, 2024, 45(9): 110-115. doi: 10.12259/j.issn.2095-610X.S20240917

Citation:

Hongmei BAO, Rong QIN, Yu ZHANG, Meiju YANG, Gang SU. Effect of PCV-VG Mode Combined with Dexmedetomidine on Intraoperative Respiratory Mechanics and Blood Gas Indicators in Patients Undergoing Laparoscopic Sleeve Gastrectomy[J]. Journal of Kunming Medical University, 2024, 45(9): 110-115. doi: 10.12259/j.issn.2095-610X.S20240917

Citation:

Hongmei BAO, Rong QIN, Yu ZHANG, Meiju YANG, Gang SU. Effect of PCV-VG Mode Combined with Dexmedetomidine on Intraoperative Respiratory Mechanics and Blood Gas Indicators in Patients Undergoing Laparoscopic Sleeve Gastrectomy[J]. Journal of Kunming Medical University, 2024, 45(9): 110-115. doi: 10.12259/j.issn.2095-610X.S20240917

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Effect of PCV-VG Mode Combined with Dexmedetomidine on Intraoperative Respiratory Mechanics and Blood Gas Indicators in Patients Undergoing Laparoscopic Sleeve Gastrectomy

doi: 10.12259/j.issn.2095-610X.S20240917

Dept. of Anesthesiology，The 1st People’s Hospital of Kunming，Kunming Yunnan 650034，China

Received Date: 2024-04-16
Available Online: 2024-09-04
Publish Date: 2024-09-25

Abstract

Abstract

Objective To explore the effects of PCV-VG ventilation mode combined with dexmedetomidine sedation on intraoperative respiratory mechanics and blood gas indicators in obese patients undergoing laparoscopic sleeve gastrectomy. Methods 132 patients who underwent laparoscopic sleeve gastrectomy at Kunming First People's Hospital from July 2022 to December 2023 were randomly divided into VCV mode group （Group V）, PCV-VG mode group （Group P）, VCV mode combined with dexmedetomidine pump group （Group D）, and PCV-VG mode combined with dexmedetomidine pump group （Group PD）, with 33 patients in each group. Then we compared the oxygen partial pressure （PaO₂）, carbon dioxide partial pressure （PaCO₂）, peak airway pressure （P_peak）, mean airway pressure （P_mean）, and lung dynamic compliance （C_dyn） of four groups of patients 20 minutes before anesthesia induction （T0）, 10 minutes after tracheal intubation （T1）, 40 minutes after CO₂ pneumoperitoneum establishment （T2）, and 10 minutes after deflation （T3）. Results （1） Blood gas indicators: At time points T2 and T3, the PaO₂ levels in the P, D, and PD groups were higher than those in the V group, with P < 0.01, indicating a statistically significant difference, Among them, the PD group was higher than the other three groups, with P < 0.01, indicating a statistically significant difference; And PaCO₂ was lower than that of Group V, P < 0.01, with statistically significant differences, Among them, the PD group was lower than the other three groups, P < 0.01, with statistically significant differences. （2） Respiratory mechanics indicators: At T1, there was no significant statistical difference in P_peak among the four groups, with P > 0.05. The P_peak of the PD group was lower than that of the V, P, and D groups at time points T2 and T3, with P < 0.01, and the difference was statistically significant; And C_dyn was higher than the other three groups, with P < 0.01, and the difference was statistically significant; At T1, T2, and T3, P_mean was lower in the PD group than in the P group, with P < 0.01, and the difference was statistically significant. Conclusion PCV-VG ventilation mode combined with intravenous infusion of dexmedetomidine can improve oxygen and function during laparoscopic sleeve gastrectomy in obese patients, reduce airway peak pressure, improve lung compliance, and reduce mechanical lung injury.
- PCV-VG,
- Dexmedetomidine,
- Laparoscopic sleeve gastrectomy,
- Blood gas,
- Respiratory mechanics

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