Meta-analysis of the Impact of Early Enteral Nutrition on the Clinical Outcomes of Very Low Birth Weight Premature Infants

Shuang FANG; Libo ZHU; Ling LIU; Yanhua XU; Xue HU

doi:10.12259/j.issn.2095-610X.S20240920

Volume 45 Issue 9

Sep. 2024

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Shuang FANG, Libo ZHU, Ling LIU, Yanhua XU, Xue HU. Meta-analysis of the Impact of Early Enteral Nutrition on the Clinical Outcomes of Very Low Birth Weight Premature Infants[J]. Journal of Kunming Medical University, 2024, 45(9): 129-135. doi: 10.12259/j.issn.2095-610X.S20240920

Citation:

Shuang FANG, Libo ZHU, Ling LIU, Yanhua XU, Xue HU. Meta-analysis of the Impact of Early Enteral Nutrition on the Clinical Outcomes of Very Low Birth Weight Premature Infants[J]. Journal of Kunming Medical University, 2024, 45(9): 129-135. doi: 10.12259/j.issn.2095-610X.S20240920

Citation:

Shuang FANG, Libo ZHU, Ling LIU, Yanhua XU, Xue HU. Meta-analysis of the Impact of Early Enteral Nutrition on the Clinical Outcomes of Very Low Birth Weight Premature Infants[J]. Journal of Kunming Medical University, 2024, 45(9): 129-135. doi: 10.12259/j.issn.2095-610X.S20240920

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Meta-analysis of the Impact of Early Enteral Nutrition on the Clinical Outcomes of Very Low Birth Weight Premature Infants

doi: 10.12259/j.issn.2095-610X.S20240920

Dept. of Neonatology，Kunming Children’s Hospital，Kunming Yunan 650228，China

Received Date: 2024-05-08
Available Online: 2024-09-03
Publish Date: 2024-09-25

Abstract

Abstract

Objective To evaluate the effect of early enteral nutrition on the clinical outcomes of very low birth weight preterm infants. Methods The literature on the use of early enteral nutrition and clinical outcome measures in VLBW premature infants was searched by computer until 31 December 2023. The data were extracted for Meta-analysis with RevMan5.4 software. Results A total of 323 articles were selected, and 8 articles were selected, with a total sample size of 3451 cases, the results of the Meta-analysis showed that early enteral nutrition for hospitalization of very low birth weight preterm infants [MD = -17.26, 95%CI （-35.41, 0.89）, P = 0.06], incidence of NEC [RR = 0.98, 95%CI （0.75, 1.27）, P = 0.85] has no effect. But early enteral nutrition can reduce the duration of full enteral feeding in very low birth weight premature infants [MD = -3.44, 95%CI （-4.15, -2.73）, P < 0.00001], reducing the time of parenteral nutrition [MD = -5.90, 95%CI （-10.42, -1.38）, P = 0.01], incidence of feeding intolerance [RR = 0.70, 95%CI （0.63, 0.77）, P < 0.00001], Reduced incidence of infection [RR = 0.57, 95%CI （0.42, 0.76）, P = 0.0001]. Conclusion Early enteral nutrition can reduce the total duration of enteral nutrition, parenteral nutrition, incidence of feeding intolerance and infection.
- Premature infants,
- Very low birth weight,
- Enteral nutrition,
- Clinical outcomes,
- Meta-analysis

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