Clinical Study of Vacuum Sealing Drainage Combined with Growth Factor in Treatment of Diabetic Foot Ulcer

Yan LYU; Yanbin WANG; Zhiguo REN; Qingxin JIANG; Ran WEI; Jiting ZHENG; Changqing FAN

doi:10.12259/j.issn.2095-610X.S20240923

Volume 45 Issue 9

Sep. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(9): 151-155

Yan LYU, Yanbin WANG, Zhiguo REN, Qingxin JIANG, Ran WEI, Jiting ZHENG, Changqing FAN. Clinical Study of Vacuum Sealing Drainage Combined with Growth Factor in Treatment of Diabetic Foot Ulcer[J]. Journal of Kunming Medical University, 2024, 45(9): 151-155. doi: 10.12259/j.issn.2095-610X.S20240923

Citation:

Yan LYU, Yanbin WANG, Zhiguo REN, Qingxin JIANG, Ran WEI, Jiting ZHENG, Changqing FAN. Clinical Study of Vacuum Sealing Drainage Combined with Growth Factor in Treatment of Diabetic Foot Ulcer[J]. Journal of Kunming Medical University, 2024, 45(9): 151-155. doi: 10.12259/j.issn.2095-610X.S20240923

Citation:

Yan LYU, Yanbin WANG, Zhiguo REN, Qingxin JIANG, Ran WEI, Jiting ZHENG, Changqing FAN. Clinical Study of Vacuum Sealing Drainage Combined with Growth Factor in Treatment of Diabetic Foot Ulcer[J]. Journal of Kunming Medical University, 2024, 45(9): 151-155. doi: 10.12259/j.issn.2095-610X.S20240923

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Clinical Study of Vacuum Sealing Drainage Combined with Growth Factor in Treatment of Diabetic Foot Ulcer

doi: 10.12259/j.issn.2095-610X.S20240923

The First Department of General Surgery，Harbin 242 Hospital，Harbin Heilongjiang 150066，China

Received Date: 2024-03-07
Available Online: 2024-09-04
Publish Date: 2024-09-25

Abstract

Abstract

Objective To investigate the clinical effect of vacuum sealing drainage （VSD） combined with human epidermal growth factor in the treatment of diabetic foot ulcers. Methods A total of 62 patients diagnosed with diabetic foot ulcer （wagner grade 2～4） hospitalized in the first department of General Surgery and Vascular Surgery of Harbin 242 Hospital from January 2022 to January 2024 were selected as the study subjects. All patients were given standard systemic basic treatments such as controlling blood pressure, blood sugar, blood lipids, anti-infection, and thorough debridement of ulcer wounds. The patients were randomly divided into control group （n = 30） and experimental group （n = 32） by using random number table. The control group received a routine treatment plan of hydropathic compress and dressing change for ulcer wounds, while the experimental group accepted VSD combined with growth factors. Compared with the effective rate, wound area, duration of antibiotic use , wound healing time, and adverse reactions of foot ulcer wounds between two groups of patients after 6 weeks of treatment. Results The effective rate （χ² = 4.26, P = 0.031） in the experimental group were significantly higher than that in the control group. The wound area in the experimental group was smaller than that in the control group after treatment（P < 0.05）, the duration of antibiotic use （t = 6.145, P < 0.001） and wound healing time （t = 9.486, P < 0.001） in the experimental group were significantly lower than these in control group. There were no obvious adverse reactions in two groups. Conclusion VSD combined with growth factor has a significant effect in the treatment of DFUs, which can enhance the treatment efficiency, reduce the duration of antibiotic use, shorten the wound healing time, safely and reliable as well.
- Diabetic foot,
- Vacuum sealing drainage,
- Growth factor

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References(21)

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