Effect Observation and Influencing Factors Analysis of Rapid Initiation of Antiretroviral Therapy

Bo TIAN; Jun LIU; Chongxi LI; Wei ZHANG; Meiqin FANG; Haiyun CHEN; Jingping BAI; Xin ZHOU; Lei CHENG; Yongmei JIN

doi:10.12259/j.issn.2095-610X.S20240925

Volume 45 Issue 9

Sep. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(9): 163-167

Bo TIAN, Jun LIU, Chongxi LI, Wei ZHANG, Meiqin FANG, Haiyun CHEN, Jingping BAI, Xin ZHOU, Lei CHENG, Yongmei JIN. Effect Observation and Influencing Factors Analysis of Rapid Initiation of Antiretroviral Therapy[J]. Journal of Kunming Medical University, 2024, 45(9): 163-167. doi: 10.12259/j.issn.2095-610X.S20240925

Citation:

Bo TIAN, Jun LIU, Chongxi LI, Wei ZHANG, Meiqin FANG, Haiyun CHEN, Jingping BAI, Xin ZHOU, Lei CHENG, Yongmei JIN. Effect Observation and Influencing Factors Analysis of Rapid Initiation of Antiretroviral Therapy[J]. Journal of Kunming Medical University, 2024, 45(9): 163-167. doi: 10.12259/j.issn.2095-610X.S20240925

Citation:

Bo TIAN, Jun LIU, Chongxi LI, Wei ZHANG, Meiqin FANG, Haiyun CHEN, Jingping BAI, Xin ZHOU, Lei CHENG, Yongmei JIN. Effect Observation and Influencing Factors Analysis of Rapid Initiation of Antiretroviral Therapy[J]. Journal of Kunming Medical University, 2024, 45(9): 163-167. doi: 10.12259/j.issn.2095-610X.S20240925

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Effect Observation and Influencing Factors Analysis of Rapid Initiation of Antiretroviral Therapy

doi: 10.12259/j.issn.2095-610X.S20240925

Dept. of Infection One，The 3rd People’s Hospital of Kunming/Yunnan Clinical Medical Center for Infectious Diseases，Kunming Yunnan 650041，China

Received Date: 2024-04-17
Available Online: 2024-08-20
Publish Date: 2024-09-25

Abstract

Abstract

Objective To investigate the efficacy of 48 weeks of rapid initiation of HIV antiviral therapy in Kunming, and analyze the influencing factors of Non-rapid initiation. Methods Data of patients initially receiving HIV antiviral treatment in The Third People's Hospital of Kunming from January 2018 to December 2022 were retrospectively collected. The time interval between diagnosis and treatment initiation was ≤7 days in the rapid ART group, and > 7 days in the non-rapid ART group. Chi-square test and T-test were used to compare the baseline demographic and clinical characteristics between the two groups and logistic regression analysis was used to analyze the influence factors. The chi-square test was used to compare the difference of CD4 count, viral inhibition rate, cohort retention rate and mortality between the two groups after 48 weeks of treatment. Results The Rapid ART rate was 32.70%, the Non-rapid ART group has higher loss rate in 48 week（χ² = 11.169, P = 0.001）, higher mortality（χ² = 3.924, P = 0.048）. The risk of Non-rapid initiation was 1.212 times higher in patients without a spouse（P = 0.040）. The risk of Non-rapid initiation in patients transmitted by intravenous drug use was 2.987 times that of heterosexual transmission（P < 0.001）. Patients with baseline CD4/CD8<0.5 had a 1.423 times greater risk of Non-rapid initiation than patients with CD4/CD8≥0.5（P = 0.001）, patients with CD4 counts≤350/μL were at higher risk for Non-rapid initiation（P = 0.047）. After 48 weeks of treatment, the virus inhibition rate in the Rapid ART group was higher than that in theNon-rapid ART group（P = 0.031）, the proportion of patients with CD4/CD8≥0.5 was higher in theRapid ART group（P < 0.001）. Conclusion Rapid initiation of antiviral therapy is beneficial to improve viral inhibition rate and cohort retention rate, and reduce mortality. For patients without spouses, with intravenous transmission and CD4/CD8<0.5, more interventions should be given to help patients receive antiviral therapy as soon as possible.
- HIV,
- AIDS,
- ART,
- Rapid ART,
- Early,
- Effect

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References(19)

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