Research Progress on Osteogenic Differentiation of Apical Papilla Stem Cells

Shibing QIAN; Huiping SHI; Yanqiu LI; Rongyu YANG; Kaiwen DUAN

doi:10.12259/j.issn.2095-610X.S20240926

Volume 45 Issue 9

Sep. 2024

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Shibing QIAN, Huiping SHI, Yanqiu LI, Rongyu YANG, Kaiwen DUAN. Research Progress on Osteogenic Differentiation of Apical Papilla Stem Cells[J]. Journal of Kunming Medical University, 2024, 45(9): 168-173. doi: 10.12259/j.issn.2095-610X.S20240926

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Shibing QIAN, Huiping SHI, Yanqiu LI, Rongyu YANG, Kaiwen DUAN. Research Progress on Osteogenic Differentiation of Apical Papilla Stem Cells[J]. Journal of Kunming Medical University, 2024, 45(9): 168-173. doi: 10.12259/j.issn.2095-610X.S20240926

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Research Progress on Osteogenic Differentiation of Apical Papilla Stem Cells

doi: 10.12259/j.issn.2095-610X.S20240926

1.
School of Stomatology，Qujing Medical College，Qujing Yunnan 655100
2.
Dept. of Stomatology，The Affiliated Yan’an Hospital，Kunming Yunnan 650051
3.
School of Stomatology，Dali University，Dali Yunnan 671003，China

Received Date: 2023-12-05
Available Online: 2024-09-03
Publish Date: 2024-09-25

Abstract

Abstract

Stem cells from apical papilla （SCAP） have a strong multi-line differentiation potential, in which osteogenic differentiation can be applied to bone tissue regeneration, providing a new idea for the treatment of oral jaw defects. Osteogenic differentiation is a complex network regulation process, and endogenous substances such as various cytokines, epigenetic material, various signaling molecules and signaling pathways can have different degrees of influence. The interaction of these factors can promote the proliferation, migration and osteogenic differentiation of SCAP, but the specific mechanisms and internal links in different processes of osteogenic differentiation of SCAP are different. In this paper, the factors that promote osteogenic differentiation of SCAP and their possible regulatory mechanisms were reviewed to provide new information for further application research.
- Apical papilla stem cells,
- Osteogenic differentiation,
- Cytokines,
- Epigenetic inheritance,
- Signal path

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References(50)

References

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