Retrospective Cohort Study of Infliximab and Vederizumab in the Treatment of Moderate-to-severe Ulcerative Colitis

Hanyu ZHANG; Juan LUO; Mingzhi DONG; Qiyin CHEN; Fengrui ZHANG; Rui GUO; Junying TONG; Yinglei MIAO

doi:10.12259/j.issn.2095-610X.S20241006

Volume 45 Issue 10

Oct. 2024

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Hanyu ZHANG, Juan LUO, Mingzhi DONG, Qiyin CHEN, Fengrui ZHANG, Rui GUO, Junying TONG, Yinglei MIAO. Retrospective Cohort Study of Infliximab and Vederizumab in the Treatment of Moderate-to-severe Ulcerative Colitis[J]. Journal of Kunming Medical University, 2024, 45(10): 36-44. doi: 10.12259/j.issn.2095-610X.S20241006

Citation:

Hanyu ZHANG, Juan LUO, Mingzhi DONG, Qiyin CHEN, Fengrui ZHANG, Rui GUO, Junying TONG, Yinglei MIAO. Retrospective Cohort Study of Infliximab and Vederizumab in the Treatment of Moderate-to-severe Ulcerative Colitis[J]. Journal of Kunming Medical University, 2024, 45(10): 36-44. doi: 10.12259/j.issn.2095-610X.S20241006

Citation:

Hanyu ZHANG, Juan LUO, Mingzhi DONG, Qiyin CHEN, Fengrui ZHANG, Rui GUO, Junying TONG, Yinglei MIAO. Retrospective Cohort Study of Infliximab and Vederizumab in the Treatment of Moderate-to-severe Ulcerative Colitis[J]. Journal of Kunming Medical University, 2024, 45(10): 36-44. doi: 10.12259/j.issn.2095-610X.S20241006

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Retrospective Cohort Study of Infliximab and Vederizumab in the Treatment of Moderate-to-severe Ulcerative Colitis

doi: 10.12259/j.issn.2095-610X.S20241006

Hanyu ZHANG^{1, 2},
Juan LUO^{1, 2},
Mingzhi DONG³,
Qiyin CHEN^{1, 2},
Fengrui ZHANG^{1, 2},
Rui GUO^{1, 2},
Junying TONG⁴,
Yinglei MIAO^{1, 2
,
,}

1.
Dept. of Gastroenterology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Yunnan Provincial Clinical Research Center for Digestive Diseases，Kunming Yunnan 650032
3.
Dept. of Gastroenterology，The 2nd People’s Hospital of Baoshan，BaoshanYunnan 678000
4.
Dept. of Gastroenterology，The People’s Hospital of Wuhua District，Kunming Yunnan 650032，China

Received Date: 2024-05-20
Available Online: 2024-10-21
Publish Date: 2024-10-31

Abstract

Abstract

Objective To compare the efficacy and safety of Infliximab （IFX） and Vedolizumab （VDZ） in the treatment of moderate-to-severe ulcerative colitis （UC）. Methods A total of 110 patients diagnosed with moderate-to-severe ulcerative colitis and treated with IFX/VDZ in the First Affiliated Hospital of Kunming Medical University from January 2020 to December 2023 were retrospectively collected. Including 55 in the IFX treatment group and 55 in the VDZ treatment group. Clinical symptoms, indicators related to disease activity, endoscopic manifestations and adverse reactions occurred during treatment were recorded before treatment （0 weeks） and 14, 30, and 54 weeks of treatment, and whether there were differences in the efficacy and safety of the two drugs in the treatment of moderate to severe UC was analyzed. Results There were no significant differences in baseline indexes between the two groups （P > 0.05）. The levels of inflammatory indicators （WBC, PLT, ESR, CRP） in IFX treatment group were higher than those in VDZ treatment group at week 14, and the level of nutrition indicator ALB was lower than those in VDZ treatment group at week 30, with statistical significance （P < 0.05）. There was no significant difference in other laboratory indexes among follow-up time points （P > 0.05）. The clinical response rate of IFX treatment group and VDZ treatment group was not significantly different at week 14 （81.8% vs 85.5%）, week 30 （80.8% vs 92.5%） and week 54 （91.3% vs 90.0%）（P > 0.05）. There was no significant difference in clinical response rate at week 14 （41.8% vs 49.1%）, week 30 （50.0% vs 67.5%） and week 54 （65.2% vs 63.3%）（P > 0.05）. There was no significant difference in endoscopic response rate at week 14 （54.3% vs 72.2%）, week 30 （41.2% vs 73.3%） and week 54 （60.0% vs 75.0%）（P > 0.05）. There was no significant difference in the endoscopic remission rate at week 14 （34.3% vs 55.6%） and week 54 （53.3% vs 54.2%）（P > 0.05）. The endoscopic remission rate at week 30 （23.5% vs 73.3%） in IFX treatment group was lower than that in VDZ treatment group, the difference was statistically significant （P = 0.005）. There was no significant difference between IFX group and VDZ group （7.3% vs 1.8%） during 14 to 30 weeks of treatment （P > 0.05）, and IFX group had higher non-response rate during 30 to 54 weeks of treatment （16.4% vs 0） than VDZ group. The difference was statistically significant （P = 0.005）. There was no significant difference in the incidence of adverse reactions between IFX treatment group and VDZ treatment group （10.9% vs 5.5%）（P > 0.05）. Conclusion During the treatment of moderate to severe UC, no significant difference was observed in the clinical response rate, clinical remission rate, endoscopic response rate and endoscopic remission rate between the IFX treatment group and the VDZ treatment group at week 14 and week 54, and the endoscopic remission rate in the IFX treatment group was lower than that in the VDZ treatment group at week 30. The non-response rateof IFX treatment group was higher than that of VDZ treatment group during maintenance treatment, suggesting that IFX treatment group may have a higher long-term drug resistance rate. There was no significant difference in the incidence of adverse reactions between the two drugs.
- Ulcerative colitis,
- Retrospective cohort study,
- Biological agent,
- Infliximab,
- Vedelizumab

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References(29)

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