Retrospective Cohort Study of Infliximab and Vederizumab in the Treatment of Moderate-to-severe Ulcerative Colitis

Hanyu ZHANG; Juan LUO; Mingzhi DONG; Qiyin CHEN; Fengrui ZHANG; Rui GUO; Junying TONG; Yinglei MIAO

doi:10.12259/j.issn.2095-610X.S20241006

Volume 45 Issue 10

Oct. 2024

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Hanyu ZHANG, Juan LUO, Mingzhi DONG, Qiyin CHEN, Fengrui ZHANG, Rui GUO, Junying TONG, Yinglei MIAO. Retrospective Cohort Study of Infliximab and Vederizumab in the Treatment of Moderate-to-severe Ulcerative Colitis[J]. Journal of Kunming Medical University, 2024, 45(10): 36-44. doi: 10.12259/j.issn.2095-610X.S20241006

Citation:

Hanyu ZHANG, Juan LUO, Mingzhi DONG, Qiyin CHEN, Fengrui ZHANG, Rui GUO, Junying TONG, Yinglei MIAO. Retrospective Cohort Study of Infliximab and Vederizumab in the Treatment of Moderate-to-severe Ulcerative Colitis[J]. Journal of Kunming Medical University, 2024, 45(10): 36-44. doi: 10.12259/j.issn.2095-610X.S20241006

Citation:

Hanyu ZHANG, Juan LUO, Mingzhi DONG, Qiyin CHEN, Fengrui ZHANG, Rui GUO, Junying TONG, Yinglei MIAO. Retrospective Cohort Study of Infliximab and Vederizumab in the Treatment of Moderate-to-severe Ulcerative Colitis[J]. Journal of Kunming Medical University, 2024, 45(10): 36-44. doi: 10.12259/j.issn.2095-610X.S20241006

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Retrospective Cohort Study of Infliximab and Vederizumab in the Treatment of Moderate-to-severe Ulcerative Colitis

doi: 10.12259/j.issn.2095-610X.S20241006

Hanyu ZHANG^{1, 2},
Juan LUO^{1, 2},
Mingzhi DONG³,
Qiyin CHEN^{1, 2},
Fengrui ZHANG^{1, 2},
Rui GUO^{1, 2},
Junying TONG⁴,
Yinglei MIAO^{1, 2
,
,}

1.
Dept. of Gastroenterology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Yunnan Provincial Clinical Research Center for Digestive Diseases，Kunming Yunnan 650032
3.
Dept. of Gastroenterology，The 2nd People’s Hospital of Baoshan，BaoshanYunnan 678000
4.
Dept. of Gastroenterology，The People’s Hospital of Wuhua District，Kunming Yunnan 650032，China

Received Date: 2024-05-20
Available Online: 2024-10-21
Publish Date: 2024-10-31

Abstract

Abstract

Objective To compare the efficacy and safety of Infliximab （IFX） and Vedolizumab （VDZ） in the treatment of moderate-to-severe ulcerative colitis （UC）. Methods A total of 110 patients diagnosed with moderate-to-severe ulcerative colitis and treated with IFX/VDZ in the First Affiliated Hospital of Kunming Medical University from January 2020 to December 2023 were retrospectively collected. Including 55 in the IFX treatment group and 55 in the VDZ treatment group. Clinical symptoms, indicators related to disease activity, endoscopic manifestations and adverse reactions occurred during treatment were recorded before treatment （0 weeks） and 14, 30, and 54 weeks of treatment, and whether there were differences in the efficacy and safety of the two drugs in the treatment of moderate to severe UC was analyzed. Results There were no significant differences in baseline indexes between the two groups （P > 0.05）. The levels of inflammatory indicators （WBC, PLT, ESR, CRP） in IFX treatment group were higher than those in VDZ treatment group at week 14, and the level of nutrition indicator ALB was lower than those in VDZ treatment group at week 30, with statistical significance （P < 0.05）. There was no significant difference in other laboratory indexes among follow-up time points （P > 0.05）. The clinical response rate of IFX treatment group and VDZ treatment group was not significantly different at week 14 （81.8% vs 85.5%）, week 30 （80.8% vs 92.5%） and week 54 （91.3% vs 90.0%）（P > 0.05）. There was no significant difference in clinical response rate at week 14 （41.8% vs 49.1%）, week 30 （50.0% vs 67.5%） and week 54 （65.2% vs 63.3%）（P > 0.05）. There was no significant difference in endoscopic response rate at week 14 （54.3% vs 72.2%）, week 30 （41.2% vs 73.3%） and week 54 （60.0% vs 75.0%）（P > 0.05）. There was no significant difference in the endoscopic remission rate at week 14 （34.3% vs 55.6%） and week 54 （53.3% vs 54.2%）（P > 0.05）. The endoscopic remission rate at week 30 （23.5% vs 73.3%） in IFX treatment group was lower than that in VDZ treatment group, the difference was statistically significant （P = 0.005）. There was no significant difference between IFX group and VDZ group （7.3% vs 1.8%） during 14 to 30 weeks of treatment （P > 0.05）, and IFX group had higher non-response rate during 30 to 54 weeks of treatment （16.4% vs 0） than VDZ group. The difference was statistically significant （P = 0.005）. There was no significant difference in the incidence of adverse reactions between IFX treatment group and VDZ treatment group （10.9% vs 5.5%）（P > 0.05）. Conclusion During the treatment of moderate to severe UC, no significant difference was observed in the clinical response rate, clinical remission rate, endoscopic response rate and endoscopic remission rate between the IFX treatment group and the VDZ treatment group at week 14 and week 54, and the endoscopic remission rate in the IFX treatment group was lower than that in the VDZ treatment group at week 30. The non-response rateof IFX treatment group was higher than that of VDZ treatment group during maintenance treatment, suggesting that IFX treatment group may have a higher long-term drug resistance rate. There was no significant difference in the incidence of adverse reactions between the two drugs.
- Ulcerative colitis,
- Retrospective cohort study,
- Biological agent,
- Infliximab,
- Vedelizumab

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References(29)

References

[1]	Le Berre C, Honap S, Peyrin-Biroulet L. Ulcerative colitis[J]. The Lancet, 2023, 402（10401）: 571-584. Le Berre C,Honap S,Peyrin-Biroulet L. Ulcerative colitis[J]. The Lancet,2023,402(10401): 571-584.
[2]	Feuerstein J D,Moss A C,Farraye F A. Ulcerative Colitis[J]. Mayo Clinic Proceedings,2019,94(7):1357-1373. doi: 10.1016/j.mayocp.2019.01.018
[3]	Nakase H,Sato N,Mizuno N,et al. The influence of cytokines on the complex pathology of ulcerative colitis[J]. Autoimmunity Reviews,2022,21(3):103017. doi: 10.1016/j.autrev.2021.103017
[4]	Kucharzik T,Koletzko S,Kannengiesser K,et al. Ulcerative colitis-diagnostic and therapeutic algorithms[J]. DeutschesArzteblatt International,2020,117(33-34):564-574.
[5]	Segal J P,Leblanc J F,Hart A L. Ulcerative colitis: an update[J/OL]. Clinical Medicine (London,England),2021,21(2): 135-139.
[6]	Spinelli A,Bonovas S,Burisch J,et al. ECCO Guidelines on Therapeutics in Ulcerative Colitis: Surgical Treatment[J]. Journal of Crohn’ s & Colitis,2022,16(2):179-189.
[7]	Macaluso F S,Orlando A,Papi C,et al. Use of biologics and small molecule drugs for the management of moderate to severe ulcerative colitis: IG-IBD clinical guidelines based on the GRADE methodology[J]. Digestive and Liver Disease: Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver,2022,54(4):440-451.
[8]	Liang S,Dai J,Hou S,et al. Structural basis for treating tumor necrosis factor α (TNFα)-associated diseases with the therapeutic antibody infliximab[J]. The Journal of Biological Chemistry,2013,288(19):13799-13807. doi: 10.1074/jbc.M112.433961
[9]	Zhou H Y,Guo B,Lufumpa E,et al. Comparative of the Effectiveness and Safety of Biological Agents,Tofacitinib,and Fecal Microbiota Transplantation in Ulcerative Colitis: Systematic Review and Network Meta-Analysis[J]. Immunological Investigations,2021,50(4):323-337. doi: 10.1080/08820139.2020.1714650
[10]	Raine T,Bonovas S,Burisch J,et al. ECCO guidelines on therapeutics in ulcerative colitis: Medical treatment[J]. Journal of Crohn’ s & Colitis,2022,16(1):2-17.
[11]	Juliao-baños F,Grillo-ardila C F,Alfaro I,et al. Update of the PANCCO clinical practice guidelines for the treatment of ulcerative colitis in the adult population[J]. Revista De Gastroenterologia De Mexico (English),2022,87(3):342-361. doi: 10.1016/j.rgmx.2022.04.007
[12]	Harbord M,Annese V,Vavricka S R,et al. The first European evidence-based consensus on extra-intestinal manifestations in inflammatory bowel disease[J]. Journal of Crohn’ s & Colitis,2016,10(3):239-254.
[13]	Tallarico M,Palleria C,Ruffolo L,et al. Biologics for inflammatory bowel disease in clinical practice: A calabria (Southern Italy) prospective pharmacovigilance study[J]. Pharmaceutics,2022,14(11):2449. doi: 10.3390/pharmaceutics14112449
[14]	Favale A,Onali S,Caprioli F,et al. Comparative efficacy of vedolizumab and adalimumab in ulcerative colitis patients previously treated with infliximab[J]. Inflammatory Bowel Diseases,2019,25(11):1805-1812. doi: 10.1093/ibd/izz057
[15]	Allamneni C,Venkata K,Yun H,et al. Comparative effectiveness of vedolizumab vs. infliximab induction therapy in ulcerative colitis: Experience of a real-world cohort at a tertiary inflammatory bowel disease center[J]. Gastroenterology Research,2018,11(1):41-45. doi: 10.14740/gr934w
[16]	Petryszyn P,Ekk-cierniakowski P,Zurakowski G. Infliximab,adalimumab,golimumab,vedolizumab and tofacitinib in moderate to severe ulcerative colitis: Comparative cost-effectiveness study in Poland[J]. Therapeutic Advances in Gastroenterology,2020,13: 1756284820941179.
[17]	Chang S,Hudesman D. First-line biologics or small molecules in inflammatory bowel disease: A practical guide for the clinician[J/OL]. Current Gastroenterology Reports,2020,22(2): 7.
[18]	Narula N,Peerani F,Meserve J,et al. Vedolizumab for ulcerative colitis: Treatment outcomes from the VICTORY consortium[J]. The American Journal of Gastroenterology,2018,113(9):1345. doi: 10.1038/s41395-018-0162-0
[19]	Ko Y,Paramsothy S,Yau Y,et al. Superior treatment persistence with ustekinumab in Crohn’ s disease and vedolizumab in ulcerative colitis compared with anti-TNF biological agents: Real-world registry data from the Persistence Australian National IBD Cohort (PANIC) study[J]. Alimentary Pharmacology & Therapeutics,2021,54(3):292-301.
[20]	中华医学会消化病学分会炎症性肠病学组,中国炎症性肠病诊疗质量控制评估中心. 中国溃疡性结肠炎诊治指南(2023年·西安)[J]. 中华炎性肠病杂志(中英文),2024,8(1):33-58.
[21]	Peyrin-biroulet L,Sandborn W,Sands B E,et al. Selecting therapeutic targets in inflammatory bowel disease (STRIDE): Determining therapeutic goals for treat-to-target[J]. The American Journal of Gastroenterology,2015,110(9):1324-1338. doi: 10.1038/ajg.2015.233
[22]	Object. Mucosal healing in ulcerative colitis: A comprehensive review[J]. [2024-04-17]. https://core.ac.uk/reader/154273783?utm_source=linkout.
[23]	Singh S,Murad M H,Fumery M,et al. First- and second-line pharmacotherapies for patients with moderate to severely active ulcerative colitis: An updated network Meta-analysis[J]. Clinical Gastroenterology and Hepatology : The Official Clinical Practice Journal of the American Gastroenterological Association,2020,18(10): 2179-2191. e6.
[24]	Sablich R,Urbano M T,Scarpa M,et al. Vedolizumab is superior to infliximab in biologic naïve patients with ulcerative colitis[J]. Scientific Reports,2023,13:1816. doi: 10.1038/s41598-023-28907-3
[25]	郭婷,党小红. 英夫利昔单抗和维多珠单抗治疗炎症性肠病的有效性及安全性比较: 间接Meta分析[J]. 胃肠病学和肝病学杂志,2022,31(5):538-546. doi: 10.3969/j.issn.1006-5709.2022.05.013
[26]	孙传熙. 维得利珠单抗和英夫利昔单抗治疗溃疡性结肠炎的临床疗效分析[D]. 乌鲁木齐:新疆医科大学,
[27]	Zhang H,Mu C,Gu Y,et al. Selection strategy of second-line biologic therapies in adult patients with ulcerative colitis following prior biologic treatment failure: Systematic review and meta-analysis[J/OL]. Pharmacological Research,2024,202: 107108.
[28]	Ma C,Huang V,Fedorak D K,et al. Crohn’ s disease outpatients treated with adalimumab have an earlier secondary loss of response and requirement for dose escalation compared to infliximab: A real life cohort study[J/OL]. Journal of Crohn’ s & Colitis,2014,8(11): 1454-1463.
[29]	Kucharzik T,Ellul P,Greuter T,et al. ECCO guidelines on the prevention,diagnosis,and management of infections in inflammatory bowel disease[J/OL]. Journal of Crohn’ s & Colitis,2021,15(6): 879-913.

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