Association between Systemic Immune-Inflammation Index and Disease Activity in Patients with Systemic Lupus Erythematosus

Feng SHEN; Yifan YANG; Ru BAI; Shu LI; Shuang LIU; Jian XU

doi:10.12259/j.issn.2095-610X.S20241007

Volume 45 Issue 10

Oct. 2024

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Feng SHEN, Yifan YANG, Ru BAI, Shu LI, Shuang LIU, Jian XU. Association between Systemic Immune-Inflammation Index and Disease Activity in Patients with Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2024, 45(10): 45-49. doi: 10.12259/j.issn.2095-610X.S20241007

Citation:

Feng SHEN, Yifan YANG, Ru BAI, Shu LI, Shuang LIU, Jian XU. Association between Systemic Immune-Inflammation Index and Disease Activity in Patients with Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2024, 45(10): 45-49. doi: 10.12259/j.issn.2095-610X.S20241007

Citation:

Feng SHEN, Yifan YANG, Ru BAI, Shu LI, Shuang LIU, Jian XU. Association between Systemic Immune-Inflammation Index and Disease Activity in Patients with Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2024, 45(10): 45-49. doi: 10.12259/j.issn.2095-610X.S20241007

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Association between Systemic Immune-Inflammation Index and Disease Activity in Patients with Systemic Lupus Erythematosus

doi: 10.12259/j.issn.2095-610X.S20241007

Feng SHEN^{1, 2},
Yifan YANG¹,
Ru BAI¹,
Shu LI¹,
Shuang LIU¹,
Jian XU^{1
,
,}

1.
Dept. of Rheumatology and Immunology，1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Dept. of Critical Care Medicine，Kaiyuan People’s Hospital，Kaiyuan Honghe 661699，China

Received Date: 2024-05-20
Available Online: 2024-10-15
Publish Date: 2024-10-31

Abstract

Abstract

Objective To explore a new method for assessing disease activity in patients with systemic lupus erythematosus （SLE） by evaluating the relationship between the level of the systemic immune-inflammatory index （SII） and disease activity in SLE patients. Methods Clinical data of SLE patients who treated in the Department of Rheumatology and Immunology of First Affiliated Hospital of Kunming Medical University were collected. Patients were grouped based on the Systemic Lupus Erythematosus Disease Activity Index （SLEDAI）. The correlation between SII level and disease activity was compared and analyzed, and Receiver operating characteristic curve （ROC） was plotted to evaluate the predictive value of SII for SLE disease activity. Results The SII levels in the mild active group of SLE patients were significantly lower than that in the severe active group （Bonferroni correction, P < 0.05/3 = 0.017）. There was a correlation between SII levels and SLEDAI scores （r = 0.130, P < 0.05）, with an area under the ROC curve of 0.581 （P < 0.05）. Conclusion SII can serve as a simple and quick reference indicator for reflecting disease activity in SLE.
- Systemic lupus erythematosus,
- Systemic immune inflammatory index,
- Systemic lupus erythematosus activity index

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References(22)

References

[1]	Li B, Yue Y, Dong C, et al. Blockade of macrophage autophagy ameliorates activated lymphocytes-derived DNA induced murine lupus possibly via inhibition of proinflammatory cytokine production[J]. Clinical and experimental rheumatology,2014,32(5):705-714.
[2]	Zhao H, Wen Z, Xiong S. Activated Lymphocyte-Derived DNA Drives Glucose Metabolic Adaptation for Inducing Macrophage Inflammatory Response in Systemic Lupus Erythematosus[J]. Cells,2023,12(16):2093.
[3]	Li M,Wang Y,Zhao J,et al. Chinese SLE treatment and research group (CSTAR) registry 2009-2019: Major clinical characteristics of chinese patients with systemic lupus erythematosus[J]. Rheumatology and Immunology Research,2021,2(1):43-47. doi: 10.2478/rir-2021-0001
[4]	2020 Chinese guidelines for the diagnosis and treatment of systemic lupus erythematosus] [J]. Zhong Hua Nei Ke Za Zhi,2020,59(3): 172-185.
[5]	Gladman D D,Ibañez D,Urowitz M B. Systemic lupus erythematosus disease activity index 2000[J]. The Journal of Rheumatology,2002,29(2):288-291.
[6]	Hu B,Yang X R,Xu Y,et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma [J]. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research,2014,20(23): 6212-6222.
[7]	周先岭,江伟,张季,等. 脑梗死后肺部感染全身免疫炎症指数和外周血NLR与RDW及PLR水平及其预后评价[J]. 中华医院感染学杂志,2024(8):1173-1177.
[8]	揭伟,刘微波,刘莎,等. 蛛网膜下腔出血患者外周血NLR、LMR、PLR和SII值变化的临床意义[J]. 脑与神经疾病杂志,2024,32(6):345-349.
[9]	高苑苑,刘传,董卫国. 全身免疫炎症指数与溃疡性结肠炎疾病活动度的相关性研究[J]. 临床内科杂志,2024,41(4):254-258.
[10]	Hochberg M C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus[J]. Arthritis and Rheumatism,1997,40(9):1725.
[11]	Carroll M. Innate immunity in the etiopathology of autoimmunity[J]. Nature immunology,2001,2(12):1089-1090.
[12]	Kim J, Gross J A, Dillon S R, et al. Increased BCMA expression in lupus marks activated B cells, and BCMA receptor engagement enhances the response to TLR9 stimulation[J]. Autoimmunity,2011,44(2):69-81.
[13]	王景鸿,潘璐,卢冰如,等. 补体C3、C4及CRP、ESR与系统性红斑狼疮疾病活动度的相关性分析[J]. 国际检验医学杂志,2024,45(11):1327-1330,1337. doi: 10.3969/j.issn.1673-4130.2024.11.010
[14]	Midgley A,Mclaren Z,Moots R J,et al. The role of neutrophil apoptosis in juvenile-onset systemic lupus erythematosus[J]. Arthritis and Rheumatism,2009,60(8):2390-2401. doi: 10.1002/art.24634
[15]	陈恬,倪晓薇,刘万莉,等. 系统性红斑狼疮患者血小板减少与淋巴细胞亚群、调节性T细胞及其细胞因子的相关性分析[J]. 免疫学杂志,2023,39(8):722-728.
[16]	Rua-figueroa Fernández de Larrinoa Í,Lozano M J C,Fernández-cid C M,et al. Preventing organ damage in systemic lupus erythematosus: The impact of early biological treatment[J]. Expert Opinion on Biological Therapy,2022,22(7):821-829. doi: 10.1080/14712598.2022.2096406
[17]	马立花,王湘宇,杨一帆,等. 536例系统性红斑狼疮患者中性粒细胞/淋巴细胞比值与疾病活动度的关联性分析[J]. 昆明医科大学学报,2022,43(2):78-81.
[18]	古彦琴. PLR与SLE疾病活动度及其肾脏损害的相关性研究 [D]. 乌鲁木齐:新疆医科大学,2023.
[19]	Jog N R,Wagner C A,Aberle T,et al. Neutrophils isolated from systemic lupus erythematosus patients exhibit a distinct functional phenotype[J]. Frontiers in Immunology,2024,15:1339250. doi: 10.3389/fimmu.2024.1339250
[20]	Becker L V,Da Silva Pereira Saccol R,Morsch V M,et al. Activity and expression of E-NTPDase is altered in peripheral lymphocytes of systemic lupus erythematosus patients[J]. Clinica Chimica Acta; International Journal of Clinical Chemistry,2019,488:90-97. doi: 10.1016/j.cca.2018.10.032
[21]	Salata M,Golbus J,Richardson B C. Diminished response to an inhibitory signal in lymphocytes from patients with systemic lupus erythematosus[J]. Clinical and Experimental Immunology,1988,71(3):439-444.
[22]	Melki I,Allaeys I,Tessandier N,et al. Platelets release mitochondrial antigens in systemic lupus erythematosus [J]. Science Translational Medicine,2021,13(581):5928

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