Association between Systemic Immune-Inflammation Index and Disease Activity in Patients with Systemic Lupus Erythematosus

Feng SHEN; Yifan YANG; Ru BAI; Shu LI; Shuang LIU; Jian XU

doi:10.12259/j.issn.2095-610X.S20241007

Volume 45 Issue 10

Oct. 2024

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Feng SHEN, Yifan YANG, Ru BAI, Shu LI, Shuang LIU, Jian XU. Association between Systemic Immune-Inflammation Index and Disease Activity in Patients with Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2024, 45(10): 45-49. doi: 10.12259/j.issn.2095-610X.S20241007

Citation:

Feng SHEN, Yifan YANG, Ru BAI, Shu LI, Shuang LIU, Jian XU. Association between Systemic Immune-Inflammation Index and Disease Activity in Patients with Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2024, 45(10): 45-49. doi: 10.12259/j.issn.2095-610X.S20241007

Citation:

Feng SHEN, Yifan YANG, Ru BAI, Shu LI, Shuang LIU, Jian XU. Association between Systemic Immune-Inflammation Index and Disease Activity in Patients with Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2024, 45(10): 45-49. doi: 10.12259/j.issn.2095-610X.S20241007

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Association between Systemic Immune-Inflammation Index and Disease Activity in Patients with Systemic Lupus Erythematosus

doi: 10.12259/j.issn.2095-610X.S20241007

Feng SHEN^{1, 2},
Yifan YANG¹,
Ru BAI¹,
Shu LI¹,
Shuang LIU¹,
Jian XU^{1
,
,}

1.
Dept. of Rheumatology and Immunology，1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Dept. of Critical Care Medicine，Kaiyuan People’s Hospital，Kaiyuan Honghe 661699，China

Received Date: 2024-05-20
Available Online: 2024-10-15
Publish Date: 2024-10-31

Abstract

Abstract

Objective To explore a new method for assessing disease activity in patients with systemic lupus erythematosus （SLE） by evaluating the relationship between the level of the systemic immune-inflammatory index （SII） and disease activity in SLE patients. Methods Clinical data of SLE patients who treated in the Department of Rheumatology and Immunology of First Affiliated Hospital of Kunming Medical University were collected. Patients were grouped based on the Systemic Lupus Erythematosus Disease Activity Index （SLEDAI）. The correlation between SII level and disease activity was compared and analyzed, and Receiver operating characteristic curve （ROC） was plotted to evaluate the predictive value of SII for SLE disease activity. Results The SII levels in the mild active group of SLE patients were significantly lower than that in the severe active group （Bonferroni correction, P < 0.05/3 = 0.017）. There was a correlation between SII levels and SLEDAI scores （r = 0.130, P < 0.05）, with an area under the ROC curve of 0.581 （P < 0.05）. Conclusion SII can serve as a simple and quick reference indicator for reflecting disease activity in SLE.
- Systemic lupus erythematosus,
- Systemic immune inflammatory index,
- Systemic lupus erythematosus activity index

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References(22)

References

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