Predictive Value of Serum and Tissue miR-205 for Postoperative Recurrence of Ovarian-type Endometriosis

Peilin CUI; Yuxia SONG; Xuejuan WANG

doi:10.12259/j.issn.2095-610X.S20241016

Volume 45 Issue 10

Oct. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(10): 105-110

Peilin CUI, Yuxia SONG, Xuejuan WANG. Predictive Value of Serum and Tissue miR-205 for Postoperative Recurrence of Ovarian-type Endometriosis[J]. Journal of Kunming Medical University, 2024, 45(10): 105-110. doi: 10.12259/j.issn.2095-610X.S20241016

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Peilin CUI, Yuxia SONG, Xuejuan WANG. Predictive Value of Serum and Tissue miR-205 for Postoperative Recurrence of Ovarian-type Endometriosis[J]. Journal of Kunming Medical University, 2024, 45(10): 105-110. doi: 10.12259/j.issn.2095-610X.S20241016

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Predictive Value of Serum and Tissue miR-205 for Postoperative Recurrence of Ovarian-type Endometriosis

doi: 10.12259/j.issn.2095-610X.S20241016

Dept. of Gynecology，Shijiazhuang People’s Hospital，Shijiazhuang Hebei 050000，China

Received Date: 2024-05-16
Available Online: 2024-11-07
Publish Date: 2024-10-31

Abstract

Abstract

Objective To explore the predictive value of serum and tissue miR-205 for postoperative recurrence of ovarian-type endometriosis （EMT）. Methods A total of 100 patients with ovarian-type EMT who were treated at Shijiazhuang People's Hospital from June 2019 to June 2021 were selected. All patients underwent laparoscopic surgery and were divided into a recurrence group （n = 24） and a non-recurrence group （n = 76） based on their recurrence status 24 months post-surgery. The general information, serum, and endometrial tissue cancer antigen 125 （CA125）, and miR-205 levels were compared between the two groups. Spearman's correlation was used to analyze the correlation between CA125 and miR-205. Receiver operating characteristic （ROC） curves and area under the curve （AUC） were plotted to analyze the predictive efficacy of miR-205 and CA125 for postoperative recurrence of ovarian EMT. The DeLong test was used to compare the differences in AUC between miR-205 and CA125 for predicting postoperative recurrence of ovarian EMT. Results There was no significant difference in the general data between the two groups （P > 0.05）. The CA125 levels in serum and ectopic endometrial tissue of the recurrent group were higher than those in the non-recurrent group, while the expression of miR-205 in serum and ectopic endometrial tissue was lower than that in the non-recurrent group （P < 0.05）. There was a negative correlation between miR-205 and CA125 in serum and endometrial tissue of patients with ovarian EMT recurrence after surgery （r = -0.728, -0.713, both P < 0.001）. The ROC curve showed that the AUC of miR-205 in serum and ectopic endometrial tissue for predicting ovarian EMT recurrence after surgery was 0.741 and 0.809, respectively. The DeLong test showed no significant difference in the AUC of miR-205 in serum and ectopic endometrial tissue compared with CA125 for predicting ovarian EMT recurrence after surgery （Z = 0.020, P = 0.951）. Conclusion The low expression of miR-205 in serum and ectopic endometrial tissue of patients with ovarian EMT recurrence after surgery is negatively correlated with CA125. Measuring miR-205 in serum and ectopic endometrial tissue can help improve the predictive efficacy and guide clinical treatment.
- Endometriosis,
- Laparoscopic surgery,
- Recurrence,
- Serum,
- Endometrial tissue,
- MiR-205

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References(26)

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