Correlation Between KL-6，IL-17 and CTD-ILD

Xingxu LIU; Meihua LI; Chaofeng REN; Weiping WANG; Li LI; Yuan BO; Chunmei ZHANG; Jing JIANG; Zhangmin ZHENG; Dongyu ZHOU

doi:10.12259/j.issn.2095-610X.S20241017

Volume 45 Issue 10

Oct. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(10): 111-115

Xingxu LIU, Meihua LI, Chaofeng REN, Weiping WANG, Li LI, Yuan BO, Chunmei ZHANG, Jing JIANG, Zhangmin ZHENG, Dongyu ZHOU. Correlation Between KL-6，IL-17 and CTD-ILD[J]. Journal of Kunming Medical University, 2024, 45(10): 111-115. doi: 10.12259/j.issn.2095-610X.S20241017

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Xingxu LIU, Meihua LI, Chaofeng REN, Weiping WANG, Li LI, Yuan BO, Chunmei ZHANG, Jing JIANG, Zhangmin ZHENG, Dongyu ZHOU. Correlation Between KL-6，IL-17 and CTD-ILD[J]. Journal of Kunming Medical University, 2024, 45(10): 111-115. doi: 10.12259/j.issn.2095-610X.S20241017

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Correlation Between KL-6，IL-17 and CTD-ILD

doi: 10.12259/j.issn.2095-610X.S20241017

Dept. of Respiratory and Critical Care Medicine，The 1st People’s Hospital of Kunming，Kunming Yunnan 650011，China

Received Date: 2024-07-20
Available Online: 2024-10-14
Publish Date: 2024-10-31

Abstract

Abstract

Objective To compare the expression levels of KL-6 and IL-17 in CTD-ILD and CTD, to explore the diagnostic value of KL-6 and IL-17 in CTD-ILD, and to analyze the correlation between KL-6 and IL-17 and pulmonary diffusion function, provide a basis for the diagnosis and severity assessment of CTD-ILD. Methods Patients who visited Kunming First People's Hospital between September 1, 2022, and January 31, 2024, were selected. A total of 30 patients with connective tissue diseases combined with interstitial lung disease were collected for the experimental group, referred to as the CTD-ILD group. 39 patients with connective tissue diseases were collected for the control group, referred to as the CTD group. The ELISA double-sandwich antibody method was used to detect KL-6 and IL-17, and correlation analysis was performed on the collected data. Results （1） Serum KL-6 and IL-17 levels in the CTD-ILD group were higher than those in the CTD group, and the difference was statistically significant （P < 0.05）. （2） There is a negative correlation between KL-6 and DLCO%pred, while there is no correlation between IL-17 and DLCO%pred（P < 0.05）. （3） The receiver operating characteristic curve （ROC） analysis showed that the AUC for KL-6 and IL-17 in diagnosing CTD-ILD were 0.902 and 0.656, respectively. Conclusion KL-6 and IL-17 can serve as indicators for diagnosing CTD-ILD, with KL-6 having a higher diagnostic value than IL-17. KL-6 can be used to assess the severity of lung diffusion function, while IL-17 is not suitable for evaluating the severity of lung diffusion function.
- Connective tissue disease combined with interstitial lung disease,
- Krebs von den lungen-6,
- Interleukin-17

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References(29)

References

[1]	中华医学会呼吸病学分会,中国医师协会呼吸医师分会. 间质性肺疾病多学科讨论规范中国专家共识[J]. 中华结核和呼吸杂志,2023,46(12):1176-1188.
[2]	Podolanczuk A J,Wong A W,Saito S,et al. Update in Interstitial Lung Disease 2020[J]. American Journal of Respiratory and Critical Care Medicine,2021,203(11):1343-1352. doi: 10.1164/rccm.202103-0559UP
[3]	Shao T,Shi X,Yang S,et al. Interstitial Lung Disease in Connective Tissue Disease: A Common Lesion With Heterogeneous Mechanisms and Treatment Considerations [J]. Frontiers in Immunology,2021,12:684699.
[4]	邹庆华,路跃武,周京国,等. 结缔组织病相关间质性肺疾病诊疗规范[J]. 中华内科杂志,2022,61(11):1217-1223. doi: 10.3760/cma.j.cn112138-20220525-00406
[5]	Wijsenbeek M,Suzuki A,Maher T M. Interstitial lung diseases[J]. Lancet (London,England),2022,400(10354):769-786. doi: 10.1016/S0140-6736(22)01052-2
[6]	Li L,Zuo X,Luo H,et al. Mortality trend of inpatients with connective tissue diseases: 2005-2014[J]. Zhong Nan Da Xue Xue Bao Yi Xue Ban = Journal of Central South University Medical sciences,2017,42(8):927-933.
[7]	张慧琴,刘学军. IL-17和IL-6在大鼠肺纤维化过程中的动态表达及意义[J]. 中国医药导报,2012,9(10):24-25+8. doi: 10.3969/j.issn.1673-7210.2012.10.013
[8]	张静静,李青,王丹阳,等. 血清KL-6水平检测在临床间质性肺病诊断中的研究进展[J]. 现代检验医学杂志,2022,37(04):198-204. doi: 10.3969/j.issn.1671-7414.2022.04.039
[9]	杨红娇. IL-27、KL-6在诊断CTD-ILD中的价值 [D]. 昆明:昆明医科大学,2019.
[10]	Cerro Chiang G,Parimon T. Understanding interstitial lung diseases associated with connective tissue disease (CTD-ILD): Genetics,cellular pathophysiology,and biologic drivers [J]. International Journal of Molecular Sciences,2023,24(3): 2405.
[11]	Kohno N,Akiyama M,Kyoizumi S,et al. Detection of soluble tumor-associated antigens in sera and effusions using novel monoclonal antibodies,KL-3 and KL-6,against lung adenocarcinoma[J]. Japanese Journal of Clinical Oncology,1988,18(3):203-216.
[12]	朱雪华,秦亦如,农骐郢,等. 血清涎液化糖链抗原6对肺部疾病预警作用研究进展[J]. 中国职业医学,2023,50(01):104-109.
[13]	Inoue Y,Kaner R J,Guiot J,et al. Diagnostic and prognostic biomarkers for chronic fibrosing interstitial lung diseases with a progressive phenotype[J]. Chest,2020,158(2):646-659. doi: 10.1016/j.chest.2020.03.037
[14]	Aloisio E,Braga F,Puricelli C,et al. Prognostic role of Krebs von den Lungen-6 (KL-6) measurement in idiopathic pulmonary fibrosis: A systematic review and meta-analysis[J]. Clinical Chemistry and Laboratory Medicine,2021,59(8):1400-1408. doi: 10.1515/cclm-2021-0199
[15]	Fathi M,Barbasso Helmers S,Lundberg I E. KL-6: a serological biomarker for interstitial lung disease in patients with polymyositis and dermatomyositis[J]. Journal of Internal Medicine,2012,271(6):589-597. doi: 10.1111/j.1365-2796.2011.02459.x
[16]	Salazar G A,Kuwana M,Wu M,et al. KL-6 but not CCL-18 is a predictor of early progression in systemic sclerosis-related interstitial lung disease[J]. The Journal of Rheumatology,2018,45(8):1153-1158. doi: 10.3899/jrheum.170518
[17]	Kim H C,Choi K H,Jacob J,et al. Prognostic role of blood KL-6 in rheumatoid arthritis-associated interstitial lung disease[J]. PloS One,2020,15(3):e0229997. doi: 10.1371/journal.pone.0229997
[18]	赵静,王静,李鸿斌. 血清涎液化糖链抗原-6水平与类风湿关节炎伴间质性肺疾病患者免疫功能的相关性研究[J]. 中华风湿病学杂志,2021,25(10):676-679. doi: 10.3760/cma.j.cn141217-20210429-00165
[19]	马芹,徐建华,王芬,等. 结缔组织病间质性肺病血清涎液化糖链抗原-6肺泡表面活性蛋白A和D及白细胞介素-6的变化及意义[J]. 中华风湿病学杂志,2017,21(1):46-49. doi: 10.3760/cma.j.issn.1007-7480.2017.01.010
[20]	刘玉梦,许爱国,赵玉苗,等. 血清KL-6对多发性肌炎/皮肌炎合并肺部疾病的临床价值[J]. 中国实用医刊,2017,44(10):10-12. doi: 10.3760/cma.j.issn.1674-4756.2017.10.004
[21]	吴雪,武丽君,罗采南,等. 涎液化糖链抗原-6在结缔组织病相关间质性肺病诊断中的应用价值[J]. 中华医学杂志,2019,99(40):3172-3175. doi: 10.3760/cma.j.issn.0376-2491.2019.40.010
[22]	杨红娇,董昭兴,王颖,等. IL-27、KL-6在诊断CTD-ILD中的价值[J]. 国际呼吸杂志,2020,40(12):911-916. doi: 10.3760/cma.j.cn131368-20190613-00869
[23]	Wakamatsu K,Nagata N,Kumazoe H,et al. Prognostic value of serial serum KL-6 measurements in patients with idiopathic pulmonary fibrosis[J]. Respiratory Investigation,2017,55(1):16-23. doi: 10.1016/j.resinv.2016.09.003
[24]	Kawaguchi M,Adachi M,Oda N,et al. IL-17 cytokine family [J]. The Journal of Allergy and Clinical Immunology,2004,114(6): 1265-1273.
[25]	Tezcan D,Sivrikaya A,Ergün D,et al. Evaluation of serum interleukin-6 (IL-6),IL-13,and IL-17 levels and computed tomography finding in interstitial lung disease associated with connective tissue disease patients[J]. Clinical Rheumatology,2021,40(11):4713-4724. doi: 10.1007/s10067-021-05773-w
[26]	Tan H L,Rosenthal M. IL-17 in lung disease: friend or foe?[J]. Thorax,2013,68(8):788-790. doi: 10.1136/thoraxjnl-2013-203307
[27]	张瑾,宋宁,高耐芬,等. IL-17和IL-6在特发性肺纤维化患者中的表达及意义[J]. 临床肺科杂志,2016,21(02):210-212+6. doi: 10.3969/j.issn.1009-6663.2016.02.006
[28]	高耐芬,郭洁,张瑾,等. 特发性肺纤维化患者免疫球蛋白A、TGF-β1、IL-6和IL-17水平变化的意义[J]. 河北医药,2019,41(06):881-883+7.
[29]	Zhang J,Wang D,Wang L,et al. Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease[J]. American Journal of Physiology Lung Cellular and Molecular Physiology,2019,316(3):L487-497. doi: 10.1152/ajplung.00301.2018

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