Application Value of HBP and PLR in AECOPD

Jing JIANG; Meihua LI; Lifen YANG; Chaofeng REN; Yalin ZHAO; Xingxu LIU; Dongyu ZHOU; Zhangmin ZHENG

doi:10.12259/j.issn.2095-610X.S20241018

Volume 45 Issue 10

Oct. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(10): 116-121

Jing JIANG, Meihua LI, Lifen YANG, Chaofeng REN, Yalin ZHAO, Xingxu LIU, Dongyu ZHOU, Zhangmin ZHENG. Application Value of HBP and PLR in AECOPD[J]. Journal of Kunming Medical University, 2024, 45(10): 116-121. doi: 10.12259/j.issn.2095-610X.S20241018

Citation:

Jing JIANG, Meihua LI, Lifen YANG, Chaofeng REN, Yalin ZHAO, Xingxu LIU, Dongyu ZHOU, Zhangmin ZHENG. Application Value of HBP and PLR in AECOPD[J]. Journal of Kunming Medical University, 2024, 45(10): 116-121. doi: 10.12259/j.issn.2095-610X.S20241018

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Application Value of HBP and PLR in AECOPD

doi: 10.12259/j.issn.2095-610X.S20241018

Dept. of Respiratory and Critical Care Medicine，The 1st People’s Hospital of Kunming，Kunming Yunnan 650011，China

Received Date: 2024-05-17
Available Online: 2024-10-14
Publish Date: 2024-10-31

Abstract

Abstract

Objective To investigate the relationship between heparin binding protein （HBP） and platelet-to-lymphocyte ratio （PLR） and acute exacerbation of chronic obstructive pulmonary disease （AECOPD）, and evaluate their clinical value in the prediction and diagnosis of AECOPD. Methods Patients with chronic obstructive pulmonary disease （COPD） who visited the inpatient department and outpatient department of Respiratory and Critical Care Medicine of Ganmei Hospital Affiliated to Kunming Medical University from November 2022 to December 2023 were selected as the study objects. Symptoms such as cough, sputum and wheezing were aggravated. COPD patients requiring hospitalization or change of treatment regimen were classified as acute COPD plus recombination （AECOPD group）, and COPD patients with no exacerbation of respiratory symptoms were classified as COPD stabilization group （SCOPD group）. Lymphocyte count and platelet values measured on the day of admission were collected, PLR values were calculated, and HBP values were measured by immunofluorescence dry quantification. The levels of HBP and PLR between the two groups and whether there were differences between the two groups were compared. Binary logistic regression analysis was used to analyze whether HBP and PLR were independent risk factors for the occurrence of AECOPD, and whether HBP and PLR had application value in predicting the occurrence of AECOPD and assisting diagnosis according to ROC curve. Results There were no significant differences in gender, age, smoking status, hypertension, diabetes, coronary heart disease and other general data between the two groups. Serum levels of HBP and PLR in AECOPD group were significantly higher than those in SCOPD group, and both HBP and PLR were independent risk factors for AECOPD. When the truncation value of HBP was 30.09 ng/mL, the sensitivity and specificity were 97.9% and 98%, respectively. When PLR truncation value is 164.0835, the sensitivity and specificity are 57.3% and 90%, respectively. The AUC value of HBP and PLR combined detection is higher than that of single index. Conclusions HBP and PLR can predict and assist the diagnosis of AECOPD, and the combined detection of HBP and PLR has a higher value in predicting and assisting the diagnosis of AECOPD.
- Acute exacerbation of chronic obstructive pulmonary disease,
- Heparin-binding protein,
- PLR

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References(18)

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