Risk Assessment and Analysis of Risk Factors for Cardiovascular Disease in HIV Antiviral Therapy Patients

Yihan LIU; Jun LIU; Yongmei JIN; Bo TIAN; Jinsong BAI

doi:10.12259/j.issn.2095-610X.S20241022

Volume 45 Issue 10

Oct. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(10): 140-146

Yihan LIU, Jun LIU, Yongmei JIN, Bo TIAN, Jinsong BAI. Risk Assessment and Analysis of Risk Factors for Cardiovascular Disease in HIV Antiviral Therapy Patients[J]. Journal of Kunming Medical University, 2024, 45(10): 140-146. doi: 10.12259/j.issn.2095-610X.S20241022

Citation:

Yihan LIU, Jun LIU, Yongmei JIN, Bo TIAN, Jinsong BAI. Risk Assessment and Analysis of Risk Factors for Cardiovascular Disease in HIV Antiviral Therapy Patients[J]. Journal of Kunming Medical University, 2024, 45(10): 140-146. doi: 10.12259/j.issn.2095-610X.S20241022

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Risk Assessment and Analysis of Risk Factors for Cardiovascular Disease in HIV Antiviral Therapy Patients

doi: 10.12259/j.issn.2095-610X.S20241022

Yihan LIU^{1, 2},
Jun LIU¹,
Yongmei JIN¹,
Bo TIAN¹,
Jinsong BAI^{1
,
,}

1.
Dept. of Infectious Disease，Kunming 3rd People’s Hospital，Kunming Yunnan 650041
2.
School of Public Health，Dali University，Dali Yunnan 671000，China

Received Date: 2024-05-21
Available Online: 2024-10-14
Publish Date: 2024-10-31

Abstract

Abstract

Objective To assess the risk of cardiovascular disease （CVD） in patients undergoing antiretroviral therapy （ART）, to understand the differences among patients with different risk levels in Kunming, and to analyze the risk factors affecting CVD. Methods From July to December 2023, a questionnaire was conducted with patients already on ART, and relevant data were collected. The D:A:D model was used to assess CVD risk, and patients were classified into low-risk, medium-risk, and high-risk groups. Chi-square tests and rank-sum tests were used to compare differences among groups, and logistic regression was performed to analyze factors influencing CVD. Results A total of 4, 139 patients were included, with 3, 119 （75.4%） in the low-risk group, 1, 020 （24.6%） in the medium- to high-risk groups [756 （18.3%） in the medium-risk group and 264 （6.3%） in the high-risk group]. Univariate logistic regression analysis showed that being male, aged ≥50 years, having a history of smoking, hypertension, a family history of CVD, homosexual transmission, being underweight, overweight, or obese, having a history of diabetes, high blood glucose, higher education （college and above）, dyslipidemia, ART duration ≥10 years, CD4 count ≥200 cells/μL, and use of ART drugs were all associated with a CVD risk ≥10% （all P < 0.05）. Multivariate logistic regression analysis showed that, among these variables, only same-sex transmission did not have a statistically significant difference （P > 0.05）. Conclusion Male gender, older age, comorbid non-AIDS-defining illnesses （such as diabetes and hypertension）, smoking history, family history of CVD, being overweight or obese, ART duration over 10 years, abnormal lipid metabolism, low CD4 cell count, and ART drug use are associated with higher CVD risk. Comprehensive HIV management should emphasize monitoring of lipid levels, blood pressure, and blood glucose to assess CVD risk, and timely intervention and treatment adjustments should be made.
- AIDS,
- HIV,
- Cardiovascular disease risk,
- D:A:D model,
- Risk factors

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References(19)

References

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