Prospects of Fecal Microbiota Transplantation for Inflammatory Bowel Disease in the Context of Biological Agents

Zhongshun NIE; Yinglei MIAO

doi:10.12259/j.issn.2095-610X.S20241023

Volume 45 Issue 10

Oct. 2024

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Zhongshun NIE, Yinglei MIAO. Prospects of Fecal Microbiota Transplantation for Inflammatory Bowel Disease in the Context of Biological Agents[J]. Journal of Kunming Medical University, 2024, 45(10): 147-154. doi: 10.12259/j.issn.2095-610X.S20241023

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Zhongshun NIE, Yinglei MIAO. Prospects of Fecal Microbiota Transplantation for Inflammatory Bowel Disease in the Context of Biological Agents[J]. Journal of Kunming Medical University, 2024, 45(10): 147-154. doi: 10.12259/j.issn.2095-610X.S20241023

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Prospects of Fecal Microbiota Transplantation for Inflammatory Bowel Disease in the Context of Biological Agents

doi: 10.12259/j.issn.2095-610X.S20241023

Zhongshun NIE,
Yinglei MIAO^,

Dept. of Gastroenterology，The 1st Affilited Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2024-06-11
Available Online: 2024-10-12
Publish Date: 2024-10-31

Abstract

Abstract

Inflammatory bowel disease （IBD） is a chronic, non-specific inflammatory condition of the intestines, and its mechanisms are still unclear, with effective treatments lacking. The advent of biologics has opened a new chapter in the treatment of IBD, with some patients achieving clinical remission or even mucosal healing. However, in clinical practice, there are still quite a few patients who either do not respond to initial treatment or experience secondary loss of response, making it difficult to fully control disease progression. Research shows that changes in the gut microbiota play a crucial role in the onset and progression of IBD, and they may serve as predictive factors for assessing the efficacy of biologics. Fecal microbiota transplantation （FMT）, as a new treatment method to restore the gut microecology of patients, has shown some effectiveness in improving IBD symptoms, inducing and maintaining mucosal healing, and even achieving histological remission. What does the future hold for the application of FMT in IBD patients in the era of biologics? This review will summarize relevant research results from both domestic and international sources to provide a theoretical basis for the potential and feasibility of using FMT in treating IBD during the biologics era.
- Inflammatory bowel disease,
- Fecal microbiota transplantation,
- Biologics,
- Gut microbiota

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References(66)

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