The Association of HOXD-AS2 and MIR3142HG Gene Polymorphisms with Cervical Intraepithelial Neoplasia

Xueya CHEN; Jinmei XU; Zhi LI; Yan LIANG; Yufeng YAO; Fengquan HE; Zhiling YAN

doi:10.12259/j.issn.2095-610X.S20241103

Volume 45 Issue 11

Nov. 2024

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Xueya CHEN, Jinmei XU, Zhi LI, Yan LIANG, Yufeng YAO, Fengquan HE, Zhiling YAN. The Association of HOXD-AS2 and MIR3142HG Gene Polymorphisms with Cervical Intraepithelial Neoplasia[J]. Journal of Kunming Medical University, 2024, 45(11): 16-21. doi: 10.12259/j.issn.2095-610X.S20241103

Citation:

Xueya CHEN, Jinmei XU, Zhi LI, Yan LIANG, Yufeng YAO, Fengquan HE, Zhiling YAN. The Association of HOXD-AS2 and MIR3142HG Gene Polymorphisms with Cervical Intraepithelial Neoplasia[J]. Journal of Kunming Medical University, 2024, 45(11): 16-21. doi: 10.12259/j.issn.2095-610X.S20241103

Citation:

Xueya CHEN, Jinmei XU, Zhi LI, Yan LIANG, Yufeng YAO, Fengquan HE, Zhiling YAN. The Association of HOXD-AS2 and MIR3142HG Gene Polymorphisms with Cervical Intraepithelial Neoplasia[J]. Journal of Kunming Medical University, 2024, 45(11): 16-21. doi: 10.12259/j.issn.2095-610X.S20241103

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The Association of HOXD-AS2 and MIR3142HG Gene Polymorphisms with Cervical Intraepithelial Neoplasia

doi: 10.12259/j.issn.2095-610X.S20241103

Xueya CHEN¹,
Jinmei XU²,
Zhi LI³,
Yan LIANG⁴,
Yufeng YAO¹,
Fengquan HE^{5
,
,},
Zhiling YAN^{2, 3
,
,}

1.
Institute of Medical Biology，Chinese Academy of Medical Sciences & Peking Union Medical College，Kunming Yunnan 650118
2.
Dept. of Gynaecologic Oncology，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118
3.
Dept. of Gynecology，The 1st People’s Hospital of Yuanmou County，Yuanmou Yunnan 651300
4.
College of Nursing Health Sciences，Yunnan Open University，Kunming Yunnan 650500
5.
Dept. of Gynaecology and Obstetrics Maternal，Maternal and Child Health Hospital of Honghe Prefecture，Honghe Yunnan 661199，China

Received Date: 2024-06-27
Available Online: 2024-11-06
Publish Date: 2024-11-25

Abstract

Abstract

Objective To explore the association of HOXD-AS2 and MIR3142HG gene polymorphism with cervical intraepithelial neoplasia （CIN）. Methods Two single nucleotide polymorphisms （SNPs） located in HOXD-AS2 （rs1348808） and located in MIR3142HG （rs2431099） were selected using bioinformatics tools. The two candidate SNPs were genotyped in 976 healthy individuals and 419 patients with CIN using the TaqMan probe method for genotyping, and the association with CIN were analyzed. Results rs1348808 C allele might be the protective factor for CIN3 as well as the progression from CIN2 to CIN3 （OR = 0.77, 95%CI: 0.63～0.94; OR = 0.57, 95%CI: 0.37～0.90）. Similarly, rs2431099 A allele might be the protective factor of CIN2 （OR = 0.50, 95%CI: 0.31～0.80）. Conclusion HOXD-AS2 and MIR3142HG gene polymorphisms might be associated with CIN.
- Cervical intraepithelial neoplasia,
- lncRNA,
- SNP,
- MAPK signaling pathway

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References(23)

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