The Effects of Caloric Restriction and Intermittent Fasting on Inflammation and Metabolic Diseases

Xibing Zhang; Ling Niu; Fang Liu; Jianghua Ran

doi:10.12259/j.issn.2095-610X.S20241201

Volume 45 Issue 12

Dec. 2024

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Xibing Zhang, Ling Niu, Fang Liu, Jianghua Ran. The Effects of Caloric Restriction and Intermittent Fasting on Inflammation and Metabolic Diseases[J]. Journal of Kunming Medical University, 2024, 45(12): 1-9. doi: 10.12259/j.issn.2095-610X.S20241201

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Xibing Zhang, Ling Niu, Fang Liu, Jianghua Ran. The Effects of Caloric Restriction and Intermittent Fasting on Inflammation and Metabolic Diseases[J]. Journal of Kunming Medical University, 2024, 45(12): 1-9. doi: 10.12259/j.issn.2095-610X.S20241201

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The Effects of Caloric Restriction and Intermittent Fasting on Inflammation and Metabolic Diseases

doi: 10.12259/j.issn.2095-610X.S20241201

Xibing Zhang¹,
Ling Niu²,
Fang Liu^{2
,
,},
Jianghua Ran^{1
,
,}

1.
Department of Hepatobiliary and Pancreatic Surgery，The Affiliated Calmette Hospital of Kunming Medical University and The First Hospital of Kunming
2.
Department of Endocrinology，The Affiliated Calmette Hospital of Kunming Medical University and The First Hospital of Kunming，KunmingYunnan 650000，China

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Corresponding author: 冉江华，博士，二级教授，博士生导师，现任昆明市第一人民医院党委副书记、云南省器官移植质量控制中心主任。享受国务院特殊津贴、云南省政府特殊津贴，并荣获云南省中青年学术和技术带头人、云南省有突出贡献优秀专业技术人才、云岭名医、云南省医学领军人才、万人计划名医、春城人才等20余项荣誉称号。学术兼职包括中国研究型医院学会移植医学专业委员会常委、中国医院协会器官获取与分配工作委员会常委、中华医学会器官移植学分会委员、中国医师协会器官移植医师分会委员、中国医师协会肝脏外科分会委员等。主要从事肝胆胰外科及器官移植领域的研究，主持国家自然科学基金及省、市科研项目10余项，获省、市科技奖励33项（其中省级一等奖2项），拥有国家专利5项、软件著作权2项，以第一或通讯作者发表论文100余篇（SCI收录20余篇），主编和参编学术著作14部，参与制定和编写指南、共识13部。
Received Date: 2024-09-22
Available Online: 2024-12-05
Publish Date: 2024-12-31

Abstract

Abstract

Caloric restriction （CR） and intermittent fasting （IF） are two dietary intervention strategies that have garnered increasing attention for their potential role in regulating inflammation and metabolic disorders. With the widespread adoption of high-calorie diets and sedentary lifestyles, the incidence of metabolic diseases such as obesity, type 2 diabetes, and cardiovascular diseases has risen significantly, posing major public health challenges. This review explores how CR and IF impact inflammation reduction and metabolic health improvement through mechanisms such as metabolic reprogramming, autophagy activation, and inhibition of inflammatory pathways. Notably, both strategies have shown promising intervention effects in inflammatory diseases like multiple sclerosis and systemic lupus erythematosus. Additionally, CR and IF demonstrate positive effects in the metabolic regulation of obesity, diabetes, and cardiovascular diseases. Despite their clinical potential, long-term adherence and safety remain key challenges for widespread implementation. Future research should focus on personalized interventions and the integration of multiple therapeutic approaches to further validate the clinical value of CR and IF. In summary, CR and IF offer novel, non-pharmacological strategies for managing chronic diseases, presenting significant potential for future clinical application.
- Caloric Restriction,
- Intermittent Fasting,
- Immune Diseases,
- Inflammatory Regulation,
- Metabolic Diseases

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References

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