Research Progress on CCL3 in the Pathogenesis of AIDS

Yuanju LIU; Xiaolan LI; Jie LIU; Yinde XU; Yun ZHU

doi:10.12259/j.issn.2095-610X.S20250201

Volume 46 Issue 2

Feb. 2025

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Abstract

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Yuanju LIU, Xiaolan LI, Jie LIU, Yinde XU, Yun ZHU. Research Progress on CCL3 in the Pathogenesis of AIDS[J]. Journal of Kunming Medical University, 2025, 46(2): 1-8. doi: 10.12259/j.issn.2095-610X.S20250201

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Research Progress on CCL3 in the Pathogenesis of AIDS

doi: 10.12259/j.issn.2095-610X.S20250201

Department of Dermatology & STD，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

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Corresponding author: 李晓岚，二级教授，一级主任医师，博士生导师。现任昆明医科大学第二附属医院皮肤性病科主任。云南省中青年学术和技术带头人，中华医学会皮肤性病学分会第十四、十五届委员会遗传学组委员，中国医师协会皮肤科医师分会第五届委员会罕见遗传病专业委员会委员，中国康复医学会皮肤病康复专业委员会第二届委员会银屑病康复学组委员，中国老年医学学会第一届皮肤医学分会常务委员，云南省医学会皮肤病与性病学分会副主任委员。共发表学术论文110余篇，其中以第一作者/通信作者发表SCI论文20篇。主持国家自然科学基金3项、省科技厅/昆明医科大学联合专项重点项目1项，中国科学院国家重点实验室开放课题1项、云南省面上项目2项。多年来一直致力于自身免疫性疾病、多基因遗传病、损容性皮肤病、皮肤美容光电技术的研究。
Received Date: 2024-02-22
Available Online: 2025-01-13
Publish Date: 2025-02-18

Abstract

Abstract

Acquired immune deficiency syndrome （AIDS） is a systemic disease caused by the Human Immunodeficiency Virus （HIV）. Chemokine （C-C motif） ligand 3 （CCL3）, as a vital member of the chemokine family, plays an indispensable role in the pathogenesis of AIDS. In the context of AIDS, CCL3 exerts significant antiviral and immunomodulatory effects by preventing HIV entry into target cells, activating immune cells to enhance antiviral capabilities, and modulating inflammatory responses, thereby influencing disease progression. Numerous studies have demonstrated that CCL3 gene copy number, specific T-cell responses, CCL3 polymorphisms, and the signaling pathways it participates in all influence the development of HIV and viral load. This article comprehensively reviews the multifaceted roles of CCL3 in AIDS, including its ability to block HIV-1 entry into immune cells, inducing the expression of antiviral proteins to inhibit viral replication, as well as the influence of its polymorphisms and alleles on HIV infection and disease progression, aiming to provide novel theoretical support for AIDS prevention and treatment strategies.
- Chemokine,
- Chemokine （C-C motif） ligand 3,
- Acquired immune deficieny syndrome

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References

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