Volume 46 Issue 2
Feb.  2025
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Min YU, Ke CHOU, Yujia LI. Effect of Repairing Patellar Cartilage Fracture with Suture Anchor[J]. Journal of Kunming Medical University, 2022, 43(2): 107-111. doi: 10.12259/j.issn.2095-610X.S20220202
Citation: Yu CHANG, Li GUI, Ruonan LI. Observation of Liraglutide's Effect on Function of Pancreatic Islets β-Cell in Type 2 Diabetes[J]. Journal of Kunming Medical University, 2025, 46(2): 134-140. doi: 10.12259/j.issn.2095-610X.S20250219
shu

Observation of Liraglutide's Effect on Function of Pancreatic Islets β-Cell in Type 2 Diabetes

doi: 10.12259/j.issn.2095-610X.S20250219

  • Department of Endocrinology，The Third People’s Hospital of Yunnan Province，Kunming Yunnan 650011，China

  • Received Date: 2024-07-08
    Available Online: 2025-01-04
  • Publish Date: 2025-02-18
    Abstract
  •   Objective  To observe the effect of the GLP-1 receptor agonist liraglutide on β-cell function in patients newly diagnosed with type 2 diabetes patients.   Methods   Type 2 diabetes patients diagnosed between March 2020 and March 2021 in the Endocrinology Department of Yunnan Provincial Third People's Hospital were recruited and randomly divided into an experimental group and a control group. The experimental group was treated with liraglutide, a GLP-1 receptor agonist, for 6 months, while the control group received treatment with non-GLP-1 receptor agonists for 6 months （monotherapy or dual therapy）. Changes in Weight, BMI, FPG, PG, HbA1c, FINS, FC-P, HOMA-IR, and HOMA-β levels were observed and measured before treatment and at 3 and 6 months after treatment.   Results  A total of 92 patients were included in the clinical observation （45 in the experimental group and 47 in the control group）. Compared to baseline, both groups showed significant reductions in FPG, 2hPG, and HbA1c at 3 and 6 months after treatment （P < 0.01）. FINS, HOMA-IR, and HOMA-β improved compared to pre-treatment levels （P < 0.05）. BMI decreased in the experimental group （P < 0.05）, while it slightly increased in the control group, but the difference was not statistically significant （P > 0.05）. Compared to the control group, the experimental group showed a greater reduction in FPG and 2hPG from baseline after 6 months of treatment, with statistically significant differences （P < 0.05）. HbA1c showed a certain decrease, but the difference was not statistically significant （P > 0.05）. FC-P in the experimental group was superior to pre-treatment levels at both 3 and 6 months （P < 0.05）, while in the control group, FC-P was only improved at the end of 6 months of treatment （P < 0.05）.   Conclusion  Early use of GLP-1 analogs in the treatment of newly diagnosed type 2 diabetes, as opposed to non-GLP-1 analog regimens, can lead to better restoration of β-cell function, weight reduction, and effective improvment of insulin resistance.
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