Expression and Prognostic Value of miR-145-5p and FSCN1 in Gastric Cancer Tissues

Fusen XUE; Dawei CHEN; Jianghua SUN

doi:10.12259/j.issn.2095-610X.S20250913

Volume 46 Issue 9

Sep. 2025

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Fusen XUE, Dawei CHEN, Jianghua SUN. Expression and Prognostic Value of miR-145-5p and FSCN1 in Gastric Cancer Tissues[J]. Journal of Kunming Medical University, 2025, 46(9): 114-120. doi: 10.12259/j.issn.2095-610X.S20250913

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Fusen XUE, Dawei CHEN, Jianghua SUN. Expression and Prognostic Value of miR-145-5p and FSCN1 in Gastric Cancer Tissues[J]. Journal of Kunming Medical University, 2025, 46(9): 114-120. doi: 10.12259/j.issn.2095-610X.S20250913

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Expression and Prognostic Value of miR-145-5p and FSCN1 in Gastric Cancer Tissues

doi: 10.12259/j.issn.2095-610X.S20250913

Comprehensive Surgery Department of Textile Hospital District，The First Hospital of Handan，Handan Hebei 056000，China

Received Date: 2025-02-12
Available Online: 2025-09-30
Publish Date: 2025-09-25

Abstract

Abstract

Objective To explore the expression and prognostic value of microRNA-145-5p （miR-145-5p） and fascin actin-bundling protein-1 （FSCN1） in gastric cancer tissues. Methods The study participants were selected from 103 gastric cancer patients treated at The First Hospital of Handan from August 2019 to August 2021. The expression levels of miR-145-5p and FSCN1 mRNA in the cancer tissues and adjacent non-cancerous tissues of gastric cancer patients were measured. Pearson correlation analysis was used to assess the relationship between the expression of miR-145-5p and FSCN1 mRNA. The area under curve （AUC） was used to evaluate the prognostic value of miR-145-5p and FSCN1 mRNA for gastric cancer patients. The Cox proportional hazards regression model was used to analyze factors influencing adverse prognosis, and Kaplan-Meier method was employed for survival analysis. Results The expression level of miR-145-5p was lower in cancer tissues compared to adjacent tissues （P < 0.05）, while the expression level of FSCN1 mRNA was higher in cancer tissues compared to adjacent tissues （P < 0.05）. The expression level of miR-145-5p was lower in cancer tissues of the patients with moderate-to-poor differentiation, tumor stage III+IV, invasion depth T3-T4, lymph node metastasis, or maximum tumor diameter ≥5 cm, compared to those with high differentiation, tumor stage I+II, invasion depth T1-T2, no lymph node metastasis, or maximum tumor diameter <5 cm, whereas the expression level of FSCN1 mRNA was higher （P < 0.05）. Pearson analysis revealed a negative correlation between miR-145-5p and FSCN1 mRNA expression in cancer tissues （r = -0.617, P = 0.000）. COX multivariate regression analysis indicated that moderate-to-poor differentiation, tumor stage III+IV, maximum tumor diameter≥5 cm, invasion depth T3-T4, low miR-145-5p expression, high FSCN1 mRNA expression, and lymph node metastasis were risk factors for poor prognosis in gastric cancer （P < 0.05）. Kaplan-Meier survival curves demonstrated a statistically significant difference in the 3-year overall survival rate between the low and high miR-145-5p expression groups （P < 0.05）. Similarly, a statistically significant difference was observed between the low and high FSCN1 mRNA expression groups （P < 0.05）. ROC curve analysis showed that the combined detection of miR-145-5p and FSCN1 mRNA yielded an AUC of 0.947 and a sensitivity of 92.3%, both of which were significantly higher than those of individual indicators （P < 0.05）. Conclusion MiR-145-5p and FSCN1 are closely related to the clinical pathological characteristics of gastric cancer patients and are effective prognostic indicators for survival.
- MicroRNA-145-5p,
- Fascin actin-bundling protein-1,
- Gastric cancer,
- Prognostic value

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