Analysis of the efficacy and safety of GM1 injection combined with batroxobin in the treatment of sudden deafness patients

Liyuan YUN; Junfeng WANG; Ning GUO; Ruimei DING; Haipeng LI; Xueping ZHANG

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Liyuan YUN, Junfeng WANG, Ning GUO, Ruimei DING, Haipeng LI, Xueping ZHANG. Analysis of the efficacy and safety of GM1 injection combined with batroxobin in the treatment of sudden deafness patients[J]. Journal of Kunming Medical University.

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Analysis of the efficacy and safety of GM1 injection combined with batroxobin in the treatment of sudden deafness patients

1.
Dept. of Ultrasound
2.
Dept. of Neurology，Affiliated Hospital of Tangshan Vocational and Technical College，Tangshan 063000，China

Received Date: 2024-01-25

Abstract

Abstract

Objective To investigate the therapeutic efficacy and safety of the combination of monosialotetrahexosylganglioside （GM1） injection and Batroxobin in treating sudden deafness. Methods The clinical data of 162 patients with sudden deafness in Affiliated Hospital of Tangshan Vocational and Technical College between January 2018 and December 2022 were selected for retrospective analysis and grouped according to the treatment protocol, 81 cases in the control group were treated with batroxobin and 81 cases in the observation group were treated with GM1 injection combined with batroxobin. The efficacy and symptom recovery time of the 2 groups were compared, as well as the levels of pure tone hearing threshold, inflammatory indexes [interleukin-10 （IL-10）, high sensitive C-reactive protein （hs-CRP）, and tumor necrosis factor-α （TNF-α）] before and after treatment, and safety. Results The total effective rate of the observation group was 92.59%, which was higher than that of the control group （59.26%）（P < 0.05）; the observation group had shorter time for dizziness to disappear, hearing to return to normal, and tinnitus to disappear than the control group （P < 0.05）; pure tone hearing thresholds in the observation group were lower than those in the control group after 7 d and 14 d of treatment （P > 0.05）; after treatment, the serum IL-10 level in the observation group was higher than that in the control group, while the levels of hs-CRP and TNF-α were lower than those in the control group（P < 0.05）; the incidence of adverse reactions in the observation group was 11.11%, compared with 9.88% in the control group, the difference was not statistically significant （P > 0.05）. Conclusion GM1 injection combined with batroxobin can effectively control the inflammatory response in patients with sudden deafness, improve hearing status, accelerate the recovery process, and has a certain degree of safety and efficacy.
- Sudden deafness,
- Batroxobin,
- GM1 injection,
- Efficacy,
- Safety

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References(20)

References

[1]	Deng Y,Shi J,Zhang M,et al. Clinical characteristics of cerebral hemorrhage with bilateral sudden deafness as the first symptom[J]. Neurol Sci,2021,42(1):141-150. doi: 10.1007/s10072-020-04515-1
[2]	陈鹏,任金龙,王银霞. 微循环障碍危险因素与突发性耳聋的研究进展[J]. 河北医药,2022,44(4):608-613. doi: 10.3969/j.issn.1002-7386.2022.04.034
[3]	李仲,张慧,汤建芬,等. 黄豆苷元片联合巴曲酶治疗突发性耳聋耳鸣的疗效观察[J]. 现代药物与临床,2021,36(6):1241-1244.
[4]	陈永禄,温丽慧,刘海媚,等. 神经节苷脂钠联合高压氧治疗突发性耳聋患者的效果评估[J]. 现代生物医学进展,2020,20(16):3181-3184,3090.
[5]	中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会. 突发性聋诊断和治疗指南(2015)[J]. 中华耳鼻咽喉头颈外科杂志,2015,50(6):443-447. doi: 10.3760/cma.j.issn.1673-0860.2015.06.002
[6]	李萍. 耳后骨膜下注射甲基强的松龙琥珀酸钠与静脉滴注地塞米松治疗突发性耳聋的疗效对比[J]. 实用临床医药杂志,2020,24(6):72-75,82.
[7]	李兴程,陈蓓,翟荣群,等. 通窍耳聋丸联合巴曲酶治疗突发性耳聋的疗效及对血液流变学的影响[J]. 现代药物与临床,2021,36(11):2356-2359.
[8]	Kilic O,Kalcioglu MT,Cag Y,et al. Could sudden sensorineural hearing loss be the sole manifestation of COVID-19?An investigation into SARS-COV-2 in the etiology of sudden sensorineural hearing loss[J]. Int J Infect Dis,2020,8(97):208-211.
[9]	丛林海,汤勇,殷家志,等. miR-26a-5p 调控SLC26A4挽救听力减退在耳聋中的作用[J]. 昆明医科大学学报,2023,44(6):14-18. doi: 10.12259/j.issn.2095-610X.S20230603
[10]	林军华,吴永明,金梅. 大剂量甲基泼尼松龙冲击联合神经节苷脂治疗对急性脊髓炎患者的临床研究[J]. 重庆医学,2021,50(14):2433-2436. doi: 10.3969/j.issn.1671-8348.2021.14.020
[11]	饶青锋,董博,闵敏,等. 单唾液酸四己糖神经节苷脂钠注射液治疗突发性耳聋的临床疗效及安全性[J]. 临床合理用药杂志,2018,11(36):69-70.
[12]	Gordon-Lipkin E,Cohen JS,Srivastava S,et al. ST3GAL5-related disorders: A deficiency in ganglioside metabolism and a genetic cause of intellectual disability and choreoathetosis[J]. J Child Neurol,2018,33(13):825-831. doi: 10.1177/0883073818791099
[13]	孙海敏,张静,王宁宁,等. GM1注射液联合高压氧治疗突发性耳聋的疗效及机制分析[J]. 中华航海医学与高气压医学杂志,2020,27(6):713-717. doi: 10.3760/cma.j.cn311847-20191220-00410
[14]	Mei X,Glueckert R,Schrott-Fischer A,et al. Vascular supply of the human spiral ganglion: Novel three-dimensional analysis using synchrotron phase-contrast imaging and histology[J]. Sci Rep,2020,3(1):5877.
[15]	张显,安竹燕,汤丽. 神经妥乐平联合单唾液酸四己糖神经节苷脂钠治疗急性缺血性脑卒中的疗效[J]. 中国临床药学杂志,2021,30(4):246-250.
[16]	云夏来. 补阳还五汤加减联合颈中交感神经节阻滞治疗神经性耳聋的临床疗效[J]. 中国民康医学,2019,31(8):114-115,134. doi: 10.3969/j.issn.1672-0369.2019.08.050
[17]	世淑兰,邱丽娟,奎莉越,等. IL-6、IL-10、hs-CRP及PCT在儿童急性淋巴细胞白血病合并感染中的诊断价值[J]. 昆明医科大学学报,2023,44(1):104-108. doi: 10.12259/j.issn.2095-610X.S20230115
[18]	谌祎玮,周建波,谢昀,等. 银杏达莫注射液联合地塞米松治疗突发性耳聋的疗效及对血清sVCAM-1、CGRP水平的影响[J]. 现代生物医学进展,2019,19(23):4565-4568.
[19]	伏飞达,朱晓燕,刘玉,等. 红花黄色素联合倍他司汀对突发性耳聋患者血液流变学、炎性因子和生活质量的影响[J]. 现代生物医学进展,2020,20(19):3699-3702,3686.
[20]	王涵,耿园园,霍英杰,等. 突发性聋患者小脑下前动脉、基底动脉与血脂水平关系[J]. 中国耳鼻咽喉头颈外科,2018,25(5):233-236.

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