2D-QSAR Studies on Flavonoids as Inhibitors of Recombinant Human Protein Kinase CK2 Holoenzyme

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2D-QSAR Studies on Flavonoids as Inhibitors of Recombinant Human Protein Kinase CK2 Holoenzyme[J]. Journal of Kunming Medical University, 2011, 32(11).

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2D-QSAR Studies on Flavonoids as Inhibitors of Recombinant Human Protein Kinase CK2 Holoenzyme[J]. Journal of Kunming Medical University, 2011, 32(11).

2D-QSAR Studies on Flavonoids as Inhibitors of Recombinant Human Protein Kinase CK2 Holoenzyme[J]. Journal of Kunming Medical University, 2011, 32(11).

Citation:

2D-QSAR Studies on Flavonoids as Inhibitors of Recombinant Human Protein Kinase CK2 Holoenzyme[J]. Journal of Kunming Medical University, 2011, 32(11).

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2D-QSAR Studies on Flavonoids as Inhibitors of Recombinant Human Protein Kinase CK2 Holoenzyme

Abstract

Abstract

Objective To establish a two-dimensional quantitative structure-activity relationship(2D-QSAR)model for predicting the inhibitory activities of flavonoids on recombinant human protein kinase CK2 holoenzyme.Method 2D-QSAR study was performed in a series of flavonoids with inhibitory activities on recombinant human protein kinase CK2 holoenzyme by combination of density functional theory,molecular mechanics and statistics.Result The established 2D-QSAR model(Eq.1)showed a reasonable regressive performance(R2 ...
- 2D-QSAR,
- Flavonoids,
- Protein kinase CK2

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