Measurement of Plasma Concentration and Pharmacokinetic Parameters of Febuxostat in Mice

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Measurement of Plasma Concentration and Pharmacokinetic Parameters of Febuxostat in Mice[J]. Journal of Kunming Medical University, 2011, 32(08).

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Measurement of Plasma Concentration and Pharmacokinetic Parameters of Febuxostat in Mice[J]. Journal of Kunming Medical University, 2011, 32(08).

Measurement of Plasma Concentration and Pharmacokinetic Parameters of Febuxostat in Mice[J]. Journal of Kunming Medical University, 2011, 32(08).

Citation:

Measurement of Plasma Concentration and Pharmacokinetic Parameters of Febuxostat in Mice[J]. Journal of Kunming Medical University, 2011, 32(08).

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Measurement of Plasma Concentration and Pharmacokinetic Parameters of Febuxostat in Mice

Abstract

Abstract

Objective To establish a LC-MS method to measure the concentration of febuxostat in plasma and to investigate pharmacokinetic profile and absolute bioavailability of the drug in BALB/c mice.Methods Febuxostat was given intravenously to mice at 10 mg/kg or orally at 50 mg/kg,respectively.Blood samples were collected at various time following drug administration.Plasma concentration of febuxostat in mice was determined by LC-MS.Pharmacokinetics parameters were calculated by DAS software,and absolute bioavaila...
- Febuxostat,
- LC-MS,
- Pharmacokinetics,
- Bioavailability

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