Effects of Luteolin on Isolated Heart Function and Oxidative Stress Reaction after Hypothermic Preservation

Yan Qing Feng

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Yan Qing Feng . Effects of Luteolin on Isolated Heart Function and Oxidative Stress Reaction after Hypothermic Preservation[J]. Journal of Kunming Medical University, 2012, 33(02).

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Yan Qing Feng . Effects of Luteolin on Isolated Heart Function and Oxidative Stress Reaction after Hypothermic Preservation[J]. Journal of Kunming Medical University, 2012, 33(02).

Yan Qing Feng . Effects of Luteolin on Isolated Heart Function and Oxidative Stress Reaction after Hypothermic Preservation[J]. Journal of Kunming Medical University, 2012, 33(02).

Citation:

Yan Qing Feng . Effects of Luteolin on Isolated Heart Function and Oxidative Stress Reaction after Hypothermic Preservation[J]. Journal of Kunming Medical University, 2012, 33(02).

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Effects of Luteolin on Isolated Heart Function and Oxidative Stress Reaction after Hypothermic Preservation

Yan Qing Feng

Abstract

Abstract

［Abstract］Objective　To study effects of luteolin on isolated heart function and oxidative stress reaction after hypothermic preservation．Methods　Forty male SD rats were randomly divided into 2 groups（n＝20 in each group）：control group（heart preservative solution was UW solution） and experiment group （added 30 μmol/L luteolin in UW solution ）．Langendorff model of isolated rat heart was used．The cardiac contractile function and diastolic function were determined 18 hours after hypothermic preservation followed by 60 min reperfusion．The amount of creatine kinase（CK）and lactic dehydrogenase（LDH）leakage in the coronary effluent，the content of Superoxide Dismutase（SOD）and malondialdehyde（MDA）in myocardial tissue were measured．Results　Luteolin significantly improved the recovery of cardiac contractile function（LVPSP，+dp/dtmax）and diastolic function（-dp/dtmax）after hypothermic preservation，reduced the leakage of CK and LDH in the coronary effluent，reduced the content of MDA in myocardial tissue and increase the content of SOD in myocardial tissue， compared with control group．Conclusion　Luteolin can significantly improve isolated heart function and reduce oxidative stress reaction in myocardial tissue after hypothermic preservation.
- ［Key words］Luteolin；Heart cold preservation；Oxidative stress,

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