Clinical Application of I125-seed Implantation Combined with Gimeracil and Oteracil Capsules Adjuvant Chemotherapy in the Treatment of Head and Neck Cancer

［Abstract］Objective　To investigate the effect of combined I125-seed implantation and gimeracil and oteracil capsules adjuvant chemotherapy on head and neck cancer．Methods　From Octorber 2008 to Octorber 2010，40 patients with head or neck cancer were selected in our hospital．Pathological types of the head or neck cancer cases were：26 cases of squamous cell carcinoma and 14 cases of poorly differentiated adenocarcinoma According to anatomical parts，the head or neck cancer cases were divided into：7 cases with hypopharyngeal Carcinoma，5 cases with maxillary sinus Carcinoma，4 cases with oral cancer；4 cases with cervical metastatic carcinoma．All patients could not receive surgery due to systemic disease or locally advanced cancer，and they were given a I125-seed implantation，the matched peripheral dose was 90～110 Gy．All patients were given two - cycle of postoperative adjuvant chemotherapy with 80 mg/m2 of gimeracil and oteracil capsules．The patients were followed up，and the acute and chronic radiation injury， local control and survival of patients were analyzed．Results　In patients with cancer，complete remission was found in 13 cases（65%），partial remission in 5 cases（25%）， invalid in 2 cases（10%），and the effective rate was 90%．Postoperative follow-up for 42 months，1 case was lost in the follow-up，the 1- year，2 - year and 3-year survival rate was 80.0%，48.75% and 13.0%， respectively. The median survival period was 16 months. Primary complications were oral mucositis and local hemorrhage. Conclusion　I125-seed implantation combined with gimeracil and oteracil capsules adjuvant chemotherapy has good therapeutic effect on head and neck cancer with surgical resection taboo，with satisfying survival rate in patients and fewer complications