The Research on the Predictable Possibility of Cervical Lesion Outcome by High Risk HPV Virus Load

［Abstract］Objective　To investigate the relationship between the high-risk human papilloma virus （HR-HPV）infection load and cervical lesions，in order to explore the feasibility of HPV load to predict the outcome of cervical disease．Methods　The HPV infection load in 143 cases of cervical intraepithelial neoplasia （CIN）and cervical cancer patients in Yunnan Province Cancer Hospital from 2010.6-2011.12 were detected by the second-generation hybrid capture（hc2 HPV DNA），to study the relationship between the high-risk HPV viral load and cervical lesions．Results　High risk HPV loads in CIN I patients were significantly lower than that in CIN II， CIN III and cervical cancer patients （P＜0.05）， there were no significant difference among the CIN II，CIN III and cervical cancer patients （P＞0.05）．Conclusion　The High-risk HPV viral loads in CIN I patients are low， which increase in CIN II， CIN III and cervical cancer patients．The viral load will not increase with the cervical lesions progress. High-risk HPV load can not predict the outcome of cervical lesions，but high HPV loads are associated with CIN II，CIN III and cervical cancer.