The Curative Effect of Polyethylene Glycol（peg）Interferon Alpha 2a Combined with Adefovir on HbeAg Positive Chronic Hepatitis B

Yang Yong Rui

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Yang Yong Rui . The Curative Effect of Polyethylene Glycol（peg）Interferon Alpha 2a Combined with Adefovir on HbeAg Positive Chronic Hepatitis B[J]. Journal of Kunming Medical University, 2012, 33(10).

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Yang Yong Rui . The Curative Effect of Polyethylene Glycol（peg）Interferon Alpha 2a Combined with Adefovir on HbeAg Positive Chronic Hepatitis B[J]. Journal of Kunming Medical University, 2012, 33(10).

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The Curative Effect of Polyethylene Glycol（peg）Interferon Alpha 2a Combined with Adefovir on HbeAg Positive Chronic Hepatitis B

Yang Yong Rui

Abstract

Abstract

［Abstract］Objective　To explore the curative effect of combination of polyethylene glycol interferon alpha 2 a and adefovir on HbeAg positive chronic hepatitis B．Methods　122 patients with HbeAg positive chronic hepatitis B were randomly divided into two groups: treatment group and control group. Patients in the treatment group were given oral administration of adefovir for 10 mg/d and subcutaneous injection of polyethylene glycol interferon alpha 2 a for 80 ug once a week for 48 weeks. Patients in the control group were only given subcutaneous injection of polyethylene glycol interferon alpha 2 a for 80 ug once a week for 48 weeks．Result　There was statistically significant difference in the serology conversion rate of HbeAg and negative transfer rate of HBV-DNA in patients between two groups after treatment for 24 week and 48 week（P＜0.05）．Conclusion　The antiviral effect of combination of adefovir and polyethylene glycol interferon alpha 2 a is better than single use of polyethylene glycol interferon alpha 2 a in treatment of HbeAg positive chronic hepatitis B.
- ［Key words］Hepatitis B；Adefovir；Polyethylene glycol（peg）；Interferon alpha α-2a,

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