前列腺癌细胞株PC-3经Doc处理后p-c-jun和AR的表达变化

Wu Jing

Volume 33 Issue 11

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Wu Jing . 前列腺癌细胞株PC-3经Doc处理后p-c-jun和AR的表达变化[J]. Journal of Kunming Medical University, 2012, 33(11).

Citation:

Wu Jing . 前列腺癌细胞株PC-3经Doc处理后p-c-jun和AR的表达变化[J]. Journal of Kunming Medical University, 2012, 33(11).

Wu Jing . 前列腺癌细胞株PC-3经Doc处理后p-c-jun和AR的表达变化[J]. Journal of Kunming Medical University, 2012, 33(11).

Citation:

Wu Jing . 前列腺癌细胞株PC-3经Doc处理后p-c-jun和AR的表达变化[J]. Journal of Kunming Medical University, 2012, 33(11).

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前列腺癌细胞株PC-3经Doc处理后p-c-jun和AR的表达变化

Wu Jing

Abstract

Abstract

［摘要］目的　探讨多西紫杉醇的细胞毒性化疗反应的分子机制．方法　对体外的免疫印迹、萤光素酶和细胞生存率进行分析，研究PC-3细胞暴露在多西紫杉醇后p-c-jun 的过表达与AR的相互作用．结果　多西紫杉醇治疗PC - 3细胞最敏感，细胞对多烯紫杉醇的敏感性与p-c-jun水平呈负相关．转染c-jun基因转染到PC - 3细胞降低了多烯紫杉醇的敏感性，而转染c-jun和AR基因则可以恢复到中等程度敏感性．p-c-jun与AR蛋白水平之间没有发现直接相关性．对多烯紫杉醇的治疗反应，体内模型的结果与体外研究结果是一致的．结论　p-c-jun可能是多西紫杉醇对前列腺癌治疗的分子机制之一

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