Yu Ping . 沙丁胺醇在3,4 -二氯苯基异氰酸酯万古霉素手性柱上的对映体分离[J]. Journal of Kunming Medical University, 2013, 34(10).
Citation: Yu Ping . 沙丁胺醇在3,4 -二氯苯基异氰酸酯万古霉素手性柱上的对映体分离[J]. Journal of Kunming Medical University, 2013, 34(10).

沙丁胺醇在3,4 -二氯苯基异氰酸酯万古霉素手性柱上的对映体分离

  • [摘要]目的 建立一种在自制手性柱上对沙丁胺醇进行了对映体分离的方法.方法 利用极性流动相中不同浓度的酸、碱添加剂在自制的3,4-二氯苯基异氰酸酯万古霉素手性柱对沙丁胺醇对映体分离的研究,初步探讨了手性识别机理.结果 流动相中酸、碱添加剂的比例为0.01%:0.01%(V/V) ,流速为1 mL/min,柱温为25℃时,沙丁胺醇获得了最好的对映体分离,选择因子为1.16,分离度达到1.41.结论 自制的3,4-二氯苯基异氰酸酯万古霉素手性柱对沙丁胺醇有一定的分离效果,可以此为参考,开发其他类似的手性固定相.

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