沙丁胺醇在3，4 -二氯苯基异氰酸酯万古霉素手性柱上的对映体分离

Yu Ping

Volume 34 Issue 10

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2013 > 34(10):

Yu Ping . 沙丁胺醇在3，4 -二氯苯基异氰酸酯万古霉素手性柱上的对映体分离[J]. Journal of Kunming Medical University, 2013, 34(10).

Citation:

Yu Ping . 沙丁胺醇在3，4 -二氯苯基异氰酸酯万古霉素手性柱上的对映体分离[J]. Journal of Kunming Medical University, 2013, 34(10).

Yu Ping . 沙丁胺醇在3，4 -二氯苯基异氰酸酯万古霉素手性柱上的对映体分离[J]. Journal of Kunming Medical University, 2013, 34(10).

Citation:

Yu Ping . 沙丁胺醇在3，4 -二氯苯基异氰酸酯万古霉素手性柱上的对映体分离[J]. Journal of Kunming Medical University, 2013, 34(10).

PDF( 193 KB)

沙丁胺醇在3，4 -二氯苯基异氰酸酯万古霉素手性柱上的对映体分离

Yu Ping

Abstract

Abstract

［摘要］目的　建立一种在自制手性柱上对沙丁胺醇进行了对映体分离的方法．方法　利用极性流动相中不同浓度的酸、碱添加剂在自制的3，4－二氯苯基异氰酸酯万古霉素手性柱对沙丁胺醇对映体分离的研究，初步探讨了手性识别机理．结果　流动相中酸、碱添加剂的比例为0.01%：0.01%（V/V），流速为1 mL/min，柱温为25℃时，沙丁胺醇获得了最好的对映体分离，选择因子为1.16，分离度达到1.41．结论　自制的3，4－二氯苯基异氰酸酯万古霉素手性柱对沙丁胺醇有一定的分离效果，可以此为参考，开发其他类似的手性固定相．

FullText(HTML)

References(0)

References

Relative Articles(20)

Relative Articles

[1]	Canyu YANG, Kongchun SUN, Juan WANG, Huiping PU, Baochun SHEN. Metabolic Differences of Propranolol Enantiomers in Different Species of Liver Microsomes by HPLC-MS/MS. Journal of Kunming Medical University, 2023, 44(3): 15-21. doi: 10.12259/j.issn.2095-610X.S20230321
[2]	Yanfei WANG, Juan MA, Yunqiao YANG. Clinical Efficacy and Safety of Sacubatril Valsartan in Patients with Reduced Ejection Fraction Combined with Hypotensive Heart Failure. Journal of Kunming Medical University, 2022, 43(11): 136-140. doi: 10.12259/j.issn.2095-610X.S20221117
[3]	Zhang-ping ZHOU, Xiao-qiong HE, Ling DUAN, Song TENG, Zhuo-xuan LIANG. Evaluation of Toxicology and Safety of Natural Active Compound Usenamine. Journal of Kunming Medical University, 2021, 42(6): 22-28. doi: 10.12259/j.issn.2095-610X.S20210642
[4]	Ye Ji Ming , Gu Xue Zhong , Chu Yu Yan , Liu Yu , Ye Ji Yun . . Journal of Kunming Medical University, 2020, 41(03): 72-76.
[5]	Chen Xi , Xu Zhi Xing , Liu Xu Jie , Tian Jin Tao , Niu Xiao Qun , Pu Jun . . Journal of Kunming Medical University, 2020, 41(09): 21-25.
[6]	Wang Ling Ling , Ma Wei Qing , Li Zhi Gui , Li Na , Huang Zhi Guo . Effect of Acute Hypervolemic Hemodilution on Hemodynamics in Patients Undergoing Lumbar Surgery. Journal of Kunming Medical University, 2019, 40(03): 83-86.
[7]	Huang Zhao Dan , Zhou Xing Liang , Chen Yan He , Lu Chang Qing , Wang Qing Yun . . Journal of Kunming Medical University, 2018, 39(09): 65-68.
[8]	Zhang Xue Qin , Xu Xiao Lin . Improvement Effect of Ulinastatin for the Oxygen Free Radical Scavenging Activity and Inflammatory Stress of Patients with Acute Pancreatitis. Journal of Kunming Medical University, 2017, 38(08): 90-93.
[9]	Xu Xiao Hong . Clinical Analysis of Preoperative Neoadjuvant Chemotherapy by Thalidomide Combined with Gefitinib for Non-small Cell Lung Cancer. Journal of Kunming Medical University,
[10]	Li Ji Yin . . Journal of Kunming Medical University,
[11]	Cheng Zhong . . Journal of Kunming Medical University,
[12]	Liu Xiao Xia . . Journal of Kunming Medical University,
[13]	Han Di . . Journal of Kunming Medical University,
[14]	Chen Fei . . Journal of Kunming Medical University,
[15]	Wang Xiao Yan . . Journal of Kunming Medical University,
[16]	Hu Yan Jie . . Journal of Kunming Medical University,
[17]	Dai Dong Mei . . Journal of Kunming Medical University,
[18]	Guo Wei . . Journal of Kunming Medical University, 2013, 34(05): 1-1.
[19]	Han Ya Qiong . . Journal of Kunming Medical University,
[20]	Jiang Zhi Min . . Journal of Kunming Medical University,