阿立哌唑与利培酮治疗阿尔茨海默病性痴呆精神症状的临床对照

Hu Dong Hui

Volume 34 Issue 12

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Hu Dong Hui . 阿立哌唑与利培酮治疗阿尔茨海默病性痴呆精神症状的临床对照[J]. Journal of Kunming Medical University, 2013, 34(12).

Citation:

Hu Dong Hui . 阿立哌唑与利培酮治疗阿尔茨海默病性痴呆精神症状的临床对照[J]. Journal of Kunming Medical University, 2013, 34(12).

Hu Dong Hui . 阿立哌唑与利培酮治疗阿尔茨海默病性痴呆精神症状的临床对照[J]. Journal of Kunming Medical University, 2013, 34(12).

Citation:

Hu Dong Hui . 阿立哌唑与利培酮治疗阿尔茨海默病性痴呆精神症状的临床对照[J]. Journal of Kunming Medical University, 2013, 34(12).

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阿立哌唑与利培酮治疗阿尔茨海默病性痴呆精神症状的临床对照

Hu Dong Hui

Abstract

Abstract

［摘要］目的　探讨阿立哌唑与利培酮治疗阿尔茨海默病性痴呆精神症状的临床疗效．方法　选择阿尔茨海默病性痴呆合并精神症状患者64例，分为利培酮+多奈哌齐组（A组）和阿立哌唑+多奈哌齐组（B组），分别于治疗前及治疗后4、8周采用BEHAV-AD量表进行评定患者病理行为，并采用副反应量表（TESS）评定药物不良反应．结果　A组治疗后4周BEHAV-AD评分较治疗前差异无统计学意义（P＞0.05），治疗8周后显著下降（P＜0.05）．B组治疗4周及8周后均出现显著下降（P＜0.05）．B组治疗4周及8周BEHAV-AD评分均显著低于A组（P＜0.05）．B组行为紊乱、抑郁、焦虑较A组均有显著性下降（P＜0.05），偏执、幻觉、攻击行为、谵妄等项差异无统计学意义（P＞0.05）．2组治疗后4周TESS评分差异无统计学意义（P＞0.05），治疗8周后B组TESS评分显著低于A组（P＜0.05）．结论　阿立哌唑+多奈哌齐可有效缓解该类患者精神症状并有较低的副反应发生，治疗阿尔茨海默病性痴呆合并精神症状效果更好．

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