The Apoptosis Effect of Docetaxel Combined with Gamma Knife on Hepatoma Cells Xenograft in Nude Mice

Li Jing Xian; He Mi; Liu Rui; Xing Yi Yuan; Jian Yuan Xi; Wang Jia Ping; Zhao Rui Min

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Article Navigation > Journal of Kunming Medical University > 2016 > 37(11): 33-36

Li Jing Xian , He Mi , Liu Rui , Xing Yi Yuan , Jian Yuan Xi , Wang Jia Ping , Zhao Rui Min . The Apoptosis Effect of Docetaxel Combined with Gamma Knife on Hepatoma Cells Xenograft in Nude Mice[J]. Journal of Kunming Medical University, 2016, 37(11): 33-36.

Citation:

Li Jing Xian , He Mi , Liu Rui , Xing Yi Yuan , Jian Yuan Xi , Wang Jia Ping , Zhao Rui Min . The Apoptosis Effect of Docetaxel Combined with Gamma Knife on Hepatoma Cells Xenograft in Nude Mice[J]. Journal of Kunming Medical University, 2016, 37(11): 33-36.

Citation:

Li Jing Xian , He Mi , Liu Rui , Xing Yi Yuan , Jian Yuan Xi , Wang Jia Ping , Zhao Rui Min . The Apoptosis Effect of Docetaxel Combined with Gamma Knife on Hepatoma Cells Xenograft in Nude Mice[J]. Journal of Kunming Medical University, 2016, 37(11): 33-36.

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The Apoptosis Effect of Docetaxel Combined with Gamma Knife on Hepatoma Cells Xenograft in Nude Mice

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基金：云南省社会发展科技计划应用基础研究基金资助项目(2009ZC111M);

Received Date: 2016-05-14

Abstract

Abstract

Objective To explore the apoptosis effect of docetaxel combined gamma knife on hepatoma cell SMMC-7721 subcutaneous xenograft in nude mice. Methods Subcutaneous xenograft models were constructed and were divided into two groups: control group and experimental group. The experimental group was treated with docetaxel 60ug/0.3ml once every 3 days for 6 times and gamma irradiation once every other day for 6 times(with indoor temperature of137 Cs radiation source irradiating the tumor and of fractionated schedule 5Gy with the total dose of 10 Gy every time). The control group was treated with physiological saline with the same dose of 60 ug/0.3 m L.Tumor growth was observed. Tumor samples were cut 30 days after the treatment and TUNEL was used to detect the apoptosis of tumor cells. Results Tumor growth rate in experimental group significantly slowed down. Apoptotic index in experimental groups was significantly higher than that in control group(P < 0.05). Conclusion Docetaxel combined gamma knife can inhibit the growth of hepatocellular carcinoma in nude mice.
- Docetaxel,
- Gamma knife,
- Xenograft in nude mice,
- Apoptotic index

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References(31)

References

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