Effect of Saponins I Extracted from Paris Polyphylla on Coronary Artery Endothelial Cell Proliferation

Wang Wei Wei; Wu Xue Song; Zhang Hong Miao; Zhang Wen; Zhang Ying; Ye Hong; Bao Tian Hao

Volume 37 Issue 11

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Wang Wei Wei , Wu Xue Song , Zhang Hong Miao , Zhang Wen , Zhang Ying , Ye Hong , Bao Tian Hao . Effect of Saponins I Extracted from Paris Polyphylla on Coronary Artery Endothelial Cell Proliferation[J]. Journal of Kunming Medical University, 2016, 37(11): 37-40.

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Effect of Saponins I Extracted from Paris Polyphylla on Coronary Artery Endothelial Cell Proliferation

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基金：云南省教育厅科研基金资助性项目(2016ZZX093);

Received Date: 2016-05-21

Abstract

Abstract

Objective To explore the effect of Paridissaponin I(PSI) on the proliferation of coronary artery endothelial cells(CAECs). Methods CAECs were cultured with PSI. CAEC growth rate was calculated by using blood cell counting plate. Cell viability was measured by MTT. The expressions of cadherin and caspase3 m RNA were detected by RT-PCR. Results PSI slowed down growth rate of CAECs, reduced cell viability of CAECs,decreased the expression of cadherin m RNA and increased the expression of caspase3 m RNA in CAECs. Conclusion PSI inhibits the proliferation of CAECs and induces CAECs apoptosis.
- Paridissaponin I,
- Coronary heart disease,
- Coronary artery endothelial cell,
- Cadherin,
- Proliferation

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