Change and Significance of Cytokine Levels in Children with Different Types of Henoch-Schonlein Purpura

Ji Xiao Fei; Zhang Ting Ting; Zhao Bo; Liu Mei; Xiong Jing Jing; Liao Ya Bin; Zhao Ya Ling; Ding Zhen Bo; Huang Yong Kun

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Article Navigation > Journal of Kunming Medical University > 2016 > 37(11): 46-50

Ji Xiao Fei , Zhang Ting Ting , Zhao Bo , Liu Mei , Xiong Jing Jing , Liao Ya Bin , Zhao Ya Ling , Ding Zhen Bo , Huang Yong Kun . Change and Significance of Cytokine Levels in Children with Different Types of Henoch-Schonlein Purpura[J]. Journal of Kunming Medical University, 2016, 37(11): 46-50.

Citation:

Ji Xiao Fei , Zhang Ting Ting , Zhao Bo , Liu Mei , Xiong Jing Jing , Liao Ya Bin , Zhao Ya Ling , Ding Zhen Bo , Huang Yong Kun . Change and Significance of Cytokine Levels in Children with Different Types of Henoch-Schonlein Purpura[J]. Journal of Kunming Medical University, 2016, 37(11): 46-50.

Citation:

Ji Xiao Fei , Zhang Ting Ting , Zhao Bo , Liu Mei , Xiong Jing Jing , Liao Ya Bin , Zhao Ya Ling , Ding Zhen Bo , Huang Yong Kun . Change and Significance of Cytokine Levels in Children with Different Types of Henoch-Schonlein Purpura[J]. Journal of Kunming Medical University, 2016, 37(11): 46-50.

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Change and Significance of Cytokine Levels in Children with Different Types of Henoch-Schonlein Purpura

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基金：国家自然科学基金资助项目(81360068); 云南省自然科学基金资助项目(2013FB137);

Received Date: 2016-07-13

Abstract

Abstract

Objective To study the change of levels of IL-6, IL-17, IL-23, IL-8, TNF-α and IFN-γ and their clinical significance on children with different types of Henoch-Schonlein purpura(HSP).Methods The blood specimens of 180 children with HSP as disease group and 30 health children as normal group were collected respectively. Disease group included 30 children at acute stage and 30 at convalescence stage of primary abdominal type,30 at acute stage and 30 at convalescence stage of primary non-abdominal type,30 at acute stage of secondary abdominal type,and 30 at acute stage of secondary non-abdominal type. The plasma levels of IL-6,IL-8,IL-17, IL-23, TNF-α and IFN-γ in the two groups were measured by ELISA method for comparison and analysis.Results The plasma levels of IL-6, IL-8, IL-17, IL-23 and TNF-α in disease group were higher than those in the normal group(P<0.05). Those levels in the children at acute stage and of primary group were also found to be higher than those at convalescence stage(P<0.05) and of secondary group(P<0.05) respectively. Comparison of IL-6, IL-8, IL-17, IL-23 and TNF-α between abdominal type and the non-abdominal type had no significant difference(P>0.05). The plasma level of IFN-γ in disease group was lower than those in normal group(P<0.05). The levels of IFN-γ in the children at acute stage and of primary group were lower than those at convalescence stage(P <0.05) and of the secondary group(P <0.05).Comparison of IFN-γ between abdominal type and non-abdominal type had no significant difference(P>0.05).Conclusions The plasma levels of IL-6, IL-8, IL-17, IL-23, TNF-α,IFN-γ show obvious changes in children with HSP, which suggests that the changes of cytokines are associated with the pathogenesis and prognosis of Henoch- Schonlein purpura.
- Henoch-Schonlein purpura,
- Children,
- Cytokine

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References(20)

References

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