Quantitative Analysis on Staging of Chronic Viral Hepatitis B and Hepatic Fibrosis by Real-time Shear Wave Elastography

Sun Yue; Wei Jia; Lu Yong Ping; Wang Jin; Zou Yu; Wang Yu Xue; Yang Mi

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Sun Yue , Wei Jia , Lu Yong Ping , Wang Jin , Zou Yu , Wang Yu Xue , Yang Mi . Quantitative Analysis on Staging of Chronic Viral Hepatitis B and Hepatic Fibrosis by Real-time Shear Wave Elastography[J]. Journal of Kunming Medical University, 2016, 37(11): 55-59.

Citation:

Sun Yue , Wei Jia , Lu Yong Ping , Wang Jin , Zou Yu , Wang Yu Xue , Yang Mi . Quantitative Analysis on Staging of Chronic Viral Hepatitis B and Hepatic Fibrosis by Real-time Shear Wave Elastography[J]. Journal of Kunming Medical University, 2016, 37(11): 55-59.

Citation:

Sun Yue , Wei Jia , Lu Yong Ping , Wang Jin , Zou Yu , Wang Yu Xue , Yang Mi . Quantitative Analysis on Staging of Chronic Viral Hepatitis B and Hepatic Fibrosis by Real-time Shear Wave Elastography[J]. Journal of Kunming Medical University, 2016, 37(11): 55-59.

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Quantitative Analysis on Staging of Chronic Viral Hepatitis B and Hepatic Fibrosis by Real-time Shear Wave Elastography

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基金：云南省高层次卫生技术人才入选学科带头人基金项目(D-201204); 云南省中青年学术和技术带头人后备人才基金项目(2010CI032); 云南省科技厅应用基础研究联合专项基金资助项目(2012FB081);

Received Date: 2016-04-10

Abstract

Abstract

Objective To explore the application value of real-time shear wave elastography(SWE)technique in diagnosing and staging of chronic viral hepatitis B and hepatic fibrosis and to establish Young's modulus reference range for diagnosing and staging of hepatic fibrosis.Methods Forty-eight patients with chronic hepatitis B and fifty-eight healthy adults were enrolled and their Young's modulus values of S5 and S6 segments of liver were measured. Histopathologic examination was performed on 48 patients with chronic hepatitis B. Comparative analysis was conducted between the pathological findings and Young's modulus values, by means of which Young's modulus reference range for diagnosis and staging of hepatic fibrosis was obtained. Results There was significant difference in Young's modulus values of S5 and S6 segments of liver between chronic hepatitis B group and the normal control group(P <0.05). Young's modulus values of S5 and S6 segments of liver in chronic hepatitis B group were(11.7±2.9) k Pa and(12.1±3.2) k Pa respectively,which were significantly higher than those in the normal control group,(5.7 ±1.1) k Pa and(5.8 ±1.3) k Pa respectively. Significant differences of Young's modulus values were detected in every staging of hepatic fibrosis(P<0.05). S5 segment of liver Young's modulus values inS0-S4 stages were(5.8±2.2) k Pa,(7.3±1.9) k Pa,(10.3±2.8) k Pa,(10.3±2.8) k Pa,and(25.3±3.6) k Pa, respectively. S6 segment of liver Young's modulus values in S0-S4 stages were(5.7 ±2.3) k Pa,(9.2 ±2.1) k Pa,(10.5 ±2.1) k Pa,(14.7 ±4.5) k Pa, and(26.1 ±2.1) k Pa, respectively. Young's modulus value of the liver rose with the increase of S stage. Conclusion SWE technique can establish the Young's modulus reference range for hepatic fibrosis stage. Besides, it features high sensitivity, specificity and accuracy.
- SWE,
- Chronic viral hepatitis B,
- Hepatic fibrosis,
- Young&apos,
- s modulus value

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References(24)

References

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