Quantitative Analysis on Staging of Chronic Viral Hepatitis B and Hepatic Fibrosis by Real-time Shear Wave Elastography

Sun Yue; Wei Jia; Lu Yong Ping; Wang Jin; Zou Yu; Wang Yu Xue; Yang Mi

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Sun Yue , Wei Jia , Lu Yong Ping , Wang Jin , Zou Yu , Wang Yu Xue , Yang Mi . Quantitative Analysis on Staging of Chronic Viral Hepatitis B and Hepatic Fibrosis by Real-time Shear Wave Elastography[J]. Journal of Kunming Medical University, 2016, 37(11): 55-59.

Citation:

Sun Yue , Wei Jia , Lu Yong Ping , Wang Jin , Zou Yu , Wang Yu Xue , Yang Mi . Quantitative Analysis on Staging of Chronic Viral Hepatitis B and Hepatic Fibrosis by Real-time Shear Wave Elastography[J]. Journal of Kunming Medical University, 2016, 37(11): 55-59.

Citation:

Sun Yue , Wei Jia , Lu Yong Ping , Wang Jin , Zou Yu , Wang Yu Xue , Yang Mi . Quantitative Analysis on Staging of Chronic Viral Hepatitis B and Hepatic Fibrosis by Real-time Shear Wave Elastography[J]. Journal of Kunming Medical University, 2016, 37(11): 55-59.

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Quantitative Analysis on Staging of Chronic Viral Hepatitis B and Hepatic Fibrosis by Real-time Shear Wave Elastography

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基金：云南省高层次卫生技术人才入选学科带头人基金项目(D-201204); 云南省中青年学术和技术带头人后备人才基金项目(2010CI032); 云南省科技厅应用基础研究联合专项基金资助项目(2012FB081);

Received Date: 2016-04-10

Abstract

Abstract

Objective To explore the application value of real-time shear wave elastography(SWE)technique in diagnosing and staging of chronic viral hepatitis B and hepatic fibrosis and to establish Young's modulus reference range for diagnosing and staging of hepatic fibrosis.Methods Forty-eight patients with chronic hepatitis B and fifty-eight healthy adults were enrolled and their Young's modulus values of S5 and S6 segments of liver were measured. Histopathologic examination was performed on 48 patients with chronic hepatitis B. Comparative analysis was conducted between the pathological findings and Young's modulus values, by means of which Young's modulus reference range for diagnosis and staging of hepatic fibrosis was obtained. Results There was significant difference in Young's modulus values of S5 and S6 segments of liver between chronic hepatitis B group and the normal control group(P <0.05). Young's modulus values of S5 and S6 segments of liver in chronic hepatitis B group were(11.7±2.9) k Pa and(12.1±3.2) k Pa respectively,which were significantly higher than those in the normal control group,(5.7 ±1.1) k Pa and(5.8 ±1.3) k Pa respectively. Significant differences of Young's modulus values were detected in every staging of hepatic fibrosis(P<0.05). S5 segment of liver Young's modulus values inS0-S4 stages were(5.8±2.2) k Pa,(7.3±1.9) k Pa,(10.3±2.8) k Pa,(10.3±2.8) k Pa,and(25.3±3.6) k Pa, respectively. S6 segment of liver Young's modulus values in S0-S4 stages were(5.7 ±2.3) k Pa,(9.2 ±2.1) k Pa,(10.5 ±2.1) k Pa,(14.7 ±4.5) k Pa, and(26.1 ±2.1) k Pa, respectively. Young's modulus value of the liver rose with the increase of S stage. Conclusion SWE technique can establish the Young's modulus reference range for hepatic fibrosis stage. Besides, it features high sensitivity, specificity and accuracy.
- SWE,
- Chronic viral hepatitis B,
- Hepatic fibrosis,
- Young&apos,
- s modulus value

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References(24)

References

[1]	[1]EL-SERAG H B.Epidemiology of viral hepatitis and hepatocellular carcinoma[J].Gastroenterology,2012,142(6):1264-1273.
[2]	[2]JEONG J Y,KIM T Y,SOHN J H,et al.Real time shear wave elastography in chronic liver diseases:Accuracy for predicting liver fibrosis,in comparison with serum markers[J].World J Gastroenterol,2014,20(38):13920-13929.
[3]	[3]LEE J E,LEE J M,LEE K B,et al.Noninvasive assessment of hepatic fibrosis in patients with chronichepatitis B viral infection using magnetic resonance elastography[J].Korean J Radiol,2014,15(2):210-217.
[4]	[4]YOON J H,LEE J M,WOO H S,et al.Staging of hepatic fibrosis:comparison of magnetic resonance elastography and shear wave elastography in the same individuals[J].Korean J Radiol,2013,14(2):202-212.
[5]	[5]FERRAIOLI G,TINELLI C,LISSANDRIN R,et al.Point shear wave elastography method for assessing liver stiffness[J].World J Gastroenterol,2014,20(16):4787-4796.
[6]	[6]EVANS A,WHELEHAN P,THOMSON K,et al.Differentiating benign from malignant solid breast masses:value of shear wave elastography according to lesion stiffness combined with greyscale ultrasound according to BI-RADS classification[J].Br J Cancer,2012,107(2):224-229.
[7] 中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南(2010版)[J].中华肝脏病杂志,2011,19(1):13-24.
[8]	[8]WONG G L,WONG V W,CHOI P C,et al.Assessment of fibrosis by transient elastography compared with liver biopsy and morphometry in chronic liver diseases[J].Clin Gastroenterol Hepatol,2008,6(9):1027-1035.
[9]	[9]KIRCHEIS G,SAGIR A,VOGT C,et al.Evaluation of acoustic radiation force impulse imaging for determination of liver stiffness using transient elastography as a reference[J].World J Gastroenterol,2012,18(10):1077-1084.
[10]	[10]HAN L,NOBLE J A,BURCHER M.A novel ultrasound indentation system for measuring biom echanical properties of in vivo soft tissue[J].Ultrasound Med Biol,2003,29(6):813-823.
[11]	[11]EVANS A,WHELEHAN P,THOMSON K,et al.Quantitative shear wave ultrasound elastography:initial experience in solid breast masses[J].Breast Cancer Res,2010,12(6):104.
[12]	[12]RYBINSKI B,FRANCO-BARRAZA J,CUKIERMAN E.The wound healing,chronic fibrosis,and cancer progression triad[J].Physiol Genomics,2014,46(7):223-244.
[13]	[13]MAK T M,HUANG Y P,ZHENG Y P.Liver fibrosis assessment using transient elastography guided with real-time B-mode ultrasound imaging:a feasibility study[J].Ultrasound Med Biol,2013,39(6):956-966.
[14]	[14]SANDRIN L,FOURQUET B,HASQUENOPH J M,et al.Transient elastography:a new noninvasive method for assessment of hepatic fibrosis[J].Ultrasound Med Biol,2003,29(12):1705-1713.
[15]	[15]XIE H,KIM K,AGLYAMOV S R,et al.Staging deep venous thrombosis using ultrasound elasticity imaging:animal model[J].Ultrasound Med Biol,2004,30(10):1385-1396.
[16]	[16]KHALIL A S,CHAN R C,CHAU A H,et al.Tissue elasticity estimation with optical coherence elastography:toward mechanical characterization of in vivo soft tissue[J].Ann Biomed Eng,2005,33(11):1631-1639.
[17]	[17]JUNKER D,DE ZORDO T,QUENTIN M.Real-time elastography of the prostate[J].Biomed Res Int,2014,2014(1):971-975.
[18]	[18]FRULIO N,TRILLAUD H.Ultrasound elastography in liver[J].Diagn Interv Imaging,2013,94(5):515-534.
[19]	[19]FRULIO N,TRILLAUD H,PEREZ P,et al.Acoustic Radiation Force Impulse(ARFI)and Transient Elastography(TE)for evaluation of liver fibrosis in HIV-HCV co-infected patients[J].BMC Infect Dis,2014,14(1):1-8.
[20]黄泽萍,曾婕,郑荣琴,等.正常人肝脏不同部位实时剪切波弹性成像效果的对比研究[J].临床超声医学杂志,2011,13(12):813-815.
[21]杨道玲,韦嘉,张勇,等.实时剪切波超声弹性成像对健康成人肝组织硬度定量分析研究[J].中国超声医学杂志,2014,30(5):411-413.
[22]曾婕,黄泽萍,郑荣琴,等.剪切波弹性成像检测正常人及慢性肝病患者肝弹性模量[J].中华超声影像学杂志,2012,21(6):481-483.
[23]	[23]FERRAIOLI G,TINELLI C,DAL BELLO B,et al.Accuracy of real-time shear wave elastography for assessing liver fibrosis in chronic hepatitis C:a pilot study[J].Hepatology,2012,56(6):2125-2133.
[24]	[24]BAVU E,GENNISSON J L,COUADE M,et al.Noninvasive in vivo liver fibrosis evaluation using supersonic shear imaging:a clinical study on 113 hepatitis C virus patients[J].Ultrasound Med Biol,2011,37(9):1361-1373.

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