Application of Serum VEGF-C,VEGFR-2 and VEGFR-3 Expression Level in Monitoring Curative Effects and Prognosis of Acute Leukemia

Shen Xiu Fen; Xue Li; Fan Shou Rui; He Xiao Juan; Wang Xue Jiao; Yu Jing Xing; Xia Mei Hua; Yin Lie Fen

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Shen Xiu Fen , Xue Li , Fan Shou Rui , He Xiao Juan , Wang Xue Jiao , Yu Jing Xing , Xia Mei Hua , Yin Lie Fen . Application of Serum VEGF-C,VEGFR-2 and VEGFR-3 Expression Level in Monitoring Curative Effects and Prognosis of Acute Leukemia[J]. Journal of Kunming Medical University, 2016, 37(11): 60-63.

Citation:

Shen Xiu Fen , Xue Li , Fan Shou Rui , He Xiao Juan , Wang Xue Jiao , Yu Jing Xing , Xia Mei Hua , Yin Lie Fen . Application of Serum VEGF-C,VEGFR-2 and VEGFR-3 Expression Level in Monitoring Curative Effects and Prognosis of Acute Leukemia[J]. Journal of Kunming Medical University, 2016, 37(11): 60-63.

Citation:

Shen Xiu Fen , Xue Li , Fan Shou Rui , He Xiao Juan , Wang Xue Jiao , Yu Jing Xing , Xia Mei Hua , Yin Lie Fen . Application of Serum VEGF-C,VEGFR-2 and VEGFR-3 Expression Level in Monitoring Curative Effects and Prognosis of Acute Leukemia[J]. Journal of Kunming Medical University, 2016, 37(11): 60-63.

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Application of Serum VEGF-C,VEGFR-2 and VEGFR-3 Expression Level in Monitoring Curative Effects and Prognosis of Acute Leukemia

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基金：云南省科技厅应用基础研究基金重点资助项目(2008CD121);

Received Date: 2016-06-10

Abstract

Abstract

Objective To observe expression level of serum vascular endothelial growth factor-C(VEGF-C), VEGF-C receptor-2 and VEGF-C receptor-3 in patients with acute leukemia(AL) and to explore its clinical significance. Methods Enzyme-linked immuno sorbent assay(ELISA) was used to detect the serum expression levels of VEGF-C, VEGFR-2, and VEGFR-3 of 51 patients diagnosed with acute leukemia, 43 patients under medical treatment and 16 healthy blood donors.Results(1) Serum VEGF-C, VEGFR-2, and VEGFR-3 expression levels in AL patients were significantly higher than those in normal control group.(2) Serum VEGF-C and VEGFR-2 expression levels in complete remission(CR) group significantly declined after treatment.Serum VEGF-C and VEGFR-2 expression levels in non-complete remission(NR) group slightly declined after treatment but no significant difference was found(P>0.05).(3) No significant difference was found in serum VEGFR-3 expression levels both in CR group and NR group after treatment(P>0.05).(4) Serum VEGF-C,VEGFR-2, and VEGFR-3 expression levels in NR group were significantly higher than those in CR group before treatment(P<0.08). Conclusions Observing serum expression level of VEGF-C,VEGFR-2,and VEGFR-3 of AL patients may be helpful in monitoring curative effects and prognosis of acute leukemia.
- Acute leukemia,
- Vascular endothelial growth factor,
- Vascular endothelial growth factor recep tor,
- Enzyme-linked immuno sorbent assay

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References(14)

References

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