Application of Sulfur Hexafluoride Micro-bubble in the Treatment of T2WI High Signal Uterine Fibroids with High Intensity Focused Ultrasound

Objective To evaluate clinical value of ultrasound contrast agent the sulfur hexafluoride micro-bubble in the treatment of T2 WI high signal uterine fibroids with high intensity focused ultrasound(HIFU).Methods A total of 36 patients with T2 WI high signal uterine fibroids were randomly divided into experimental group and control group. Eighteen patients in experimental group received HIFU treatment with sulfur hexafluoride micro-bubble before, during and after the operation while another eighteen in control group received HIFU treatment with sulfur hexafluoride micro-bubble only after the operation. We recorded operation time(min),changing time of massive gray(s),irradiation time(s),therapeutic dose(J),incidence of complications and ablation rate(%). Results Operation time, changing time of massive gray, irradiation time,and therapeutic dose in experimental group were(101.51±43.02) min,(856.42±451.14) s,(1 077.37±546.23) s,and(496581.81 ±267192.31) J, respectively while those in control group were(261.34 ±85.53) min,(1833.32±642.67) s,(1 890.21±1 268.43) s,and(784 608.31±357 621.45) J,respectively. Significant differences were found among those parameters between the two groups(P <0.05). Tumor ablation rate in experimental group was 83.3% while that in control group was 55.5%, which was of significant difference between the two groups(P<0.05). One case of muscular stiffness was found in experimental group while one case of second-degree burn and two cases of muscular stiffness were found in the control group.The incidence of complications was 1/18(5.5%). No severe complication like bowel perforation or bladder perforation was found in the two groups. Conclusion The effect of ultrasound contrast agent sulfur hexafluoride micro-bubble can shorten operation time, improve tumor ablation rate and reduce complications and it can play a guiding role in clinical work.