Protective Effects of Rosemary's Extract on Cerebral Ischemia in Mice and Acute Toxicity Evaluation

Zhang Lan Chun; Wang Shang Wen; Hu Wei Yan; Zhao Rong Hua; Yu Hao Fei; Zhang Rong Ping

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Zhang Lan Chun , Wang Shang Wen , Hu Wei Yan , Zhao Rong Hua , Yu Hao Fei , Zhang Rong Ping . Protective Effects of Rosemary's Extract on Cerebral Ischemia in Mice and Acute Toxicity Evaluation[J]. Journal of Kunming Medical University, 2016, 37(12): 16-19.

Citation:

Zhang Lan Chun , Wang Shang Wen , Hu Wei Yan , Zhao Rong Hua , Yu Hao Fei , Zhang Rong Ping . Protective Effects of Rosemary's Extract on Cerebral Ischemia in Mice and Acute Toxicity Evaluation[J]. Journal of Kunming Medical University, 2016, 37(12): 16-19.

Citation:

Zhang Lan Chun , Wang Shang Wen , Hu Wei Yan , Zhao Rong Hua , Yu Hao Fei , Zhang Rong Ping . Protective Effects of Rosemary's Extract on Cerebral Ischemia in Mice and Acute Toxicity Evaluation[J]. Journal of Kunming Medical University, 2016, 37(12): 16-19.

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Protective Effects of Rosemary's Extract on Cerebral Ischemia in Mice and Acute Toxicity Evaluation

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(2016FB014;2015FB006); 云南省高校协同创新中心-南药研究协同中心基金资助项目(NY2014002);

Received Date: 2016-10-10

Abstract

Abstract

Objective To evaluate the protective effects of Rosemary's chloroform extract on cerebral ischemia in mice and acute toxicity.Methods The protective of rosemary's chloroform extract on cerebral ischemia was observed and compared by the mice models of cerebral anoxia and ischemia,thrombus formation in vivo, and chloroform induced arrhythmias.Rosemary's Chloroform Extract was given orally to mice to evaluate acute toxicity.Results Rosemary's chloroform extract had different degrees of inhibition of collagen-the adrenaline induced thrombus formation,and prolonged acute ischemic mice brains off mouth breathing time and increase the number of mouth breathing(P <0.05 or P <0.01); Chloroform extract significantly reduced the incidence of chloroform induced ventricular arrhythmias.Acute toxicity results suggested that a female rat died in the next day of chloroform extract group,no additional toxicity was observed.Conclusion Rosemary's chloroform extract has significant protective effect on cerebral ischemia and hypoxia in mice.
- Rosemary&apos,
- s chloroform extract,
- Cerebral ischemia,
- Acute toxicity evaluation

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References(15)

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