The Effects of Mild Hypothermia on MODS Caused by Cerebral Hemorrhage

Wei Liang; Wang Qi; Yang Cheng; Zhang Yan Fei; Guan Hong Xin; Sun Zhi Yang

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Article Navigation > Journal of Kunming Medical University > 2016 > 37(12): 57-61

Wei Liang , Wang Qi , Yang Cheng , Zhang Yan Fei , Guan Hong Xin , Sun Zhi Yang . The Effects of Mild Hypothermia on MODS Caused by Cerebral Hemorrhage[J]. Journal of Kunming Medical University, 2016, 37(12): 57-61.

Citation:

Wei Liang , Wang Qi , Yang Cheng , Zhang Yan Fei , Guan Hong Xin , Sun Zhi Yang . The Effects of Mild Hypothermia on MODS Caused by Cerebral Hemorrhage[J]. Journal of Kunming Medical University, 2016, 37(12): 57-61.

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The Effects of Mild Hypothermia on MODS Caused by Cerebral Hemorrhage

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基金：上海市浦东新区卫生和计划生育委员会面上基金资助项目(PW2014A-15); 上海市卫计委面上基金资助项目(201440319);

Received Date: 2016-09-16

Abstract

Abstract

Objective To disscuss and analyze the clinical effects of whole body mild hypothermia on MODS caused by cerebral hemorrhage.Methods One hundred and eighty patients with MODS caused by cerebral hemorrhage during the period of hospitalized from January 2013 to December 2015 in ICU of our hospital were divided into two groups(observation group and control group) randomly,90 cases patients in each group.Patients in control group were treated with conventional treatment intervention,patients in control group were treated with whole body mild hypothermia on the base of conventional treatment intervention,the score of MODS,the ratio of,VO2 and DO2, the time during the period of hospitalized in ICU, the time of mechanical ventilation, epilepsy incidence and mortality, NIHSS score and PADL score of the patients in these two group after treatment were compared.Results After the comparion,the score of MODS and the state of oxygen consumption and oxygen supply of the patients in observation group were better than the patients in control group, there was significant differences,and had statistical significance(P<0.05);the time during the period of hospitalized in ICU and the time of mechanical ventilation of the patients in observation group were shorter than the patients in control group,there was significant difference,and had statistical significance(P<0.05);the mortality were reduce significantly of the patients in observation group than the patients in control group,there was significant difference,and had statistical significance(P<0.05);the epilepsy incidence of the patients in observation group and control has no significant difference,has no statistical significance(P>0.05);the NIHSS score and PADL score of the patients in observation group were higher than the patients in control group, there was significant difference, and has statistical significance(P<0.05).Conclusion The clinical effects of whole body mild hypothermia on MODS caused by cerebral hemorrhage have important significance,can effectively improve the balance of multiple organ dysfunction syndrome patients,can delay the progression of multiple organ dysfunction syndrome patients, improve the prognosis,it is worthy of clinical application and promotion.
- Cerebral hemorrhage,
- Multiple organ dysfunction syndrome,
- Mild hypothermia

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References(15)

References

[1]李萍,赵树明,胡亚男,等.脑出血发病机制研究进展[J].中华老年心脑血管病杂志,2015,2(17):214-216.
[2]	[2]ZHANG C,LEE Y Y,KEEP R F,et al.Brain cdema formation and complement activation in a rat model of subarachnoid hemorrhage[J].Acta Neurochir Suppl,2013:1(118):157-161.
[3]陈以胜,赵明亮,梁海乾,等.亚低温后脑损伤组织提取液对体外脐带间充质干细胞的影响[J].中华创伤杂志,2016,1(32):80-83.
[4]于垚,高旭光.去铁胺治疗脑出血的研究进展[J].中华临床医师杂志(电子版),2014,9(8):1722-1726.
[5]文明,丛明,张振兴.微创与开颅手术在脑出血治疗中的疗效及安全性比较[J].中华神经外科疾病研究杂志,2014,13(4):90-363.
[6]李致文,吴丽娥.脑出血急性期的血压调控[J].中华老年心脑血管病杂志,2013,10(15):115-1118.
[7]杨中良,杨秀云,郭梅凤,等.老年脑出血昏迷患者继发MODS的危险因素分析[J].中华老年心脑血管病杂志,2013,8(15):835-838.
[8]王超,苏强,张淑文,等.多器官功能障碍综合征诊断标准的多中心临床研究[J].中华外科杂志,2009,47(1):40-45.
[9]	[9]YENARI M A,HAN H S.Neuroprotective mechanisms of hypothermia in brain ischemia[J].Nat Rev Neurosci,2012,13(4):267-268.
[10]	[10]KONSTANINIDIS A,INADA K,DUBOSE J,et al.The impact of nontherapeutic hypothermia on outcomes after severe traumatic brain injury[J].J Trauma,2011,71(118):1627-1631.
[11]	[11]SHANKARAN S,PAPPAS A,MCDONALD SA,et al.Childhood outcomes after hypothermia for neonatal encephalopathy[J].N Engl J Med,2012,366(22):2085-2092.
[12]李萍,赵建军,赵树明.活血化瘀法治疗脑出血的实验研究进展[J].中华老年心脑血管病杂志,2012,10(14):1117-1119.
[13]于湘友,李娜.连续性血液净化治疗多器官功能障碍综合征疗效分析[J].中华肾脏病杂志,2011,4(27):235-238.
[14]肖红艳,许卫江,刘彬,等.亚低温血液净化技术在心脏瓣膜病术后心源性休克治疗中的应用[J].中国急救医学,2015,9(35):836-838.
[15]	[15]TU Y,CHEN C,SUN H T,et al.Combination of temperature sensitive stem cells and mild hypothermia:a new potenial therapy for severe traumatic brain injury[J].J Neurotrauma,2012,29(14):2393-2403.

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