Expression of IL-17 and IL-23 in Patients with B-cell non-HodgkinLymphoma Treated by RCHOP

Huang Ying; Liu Yi Han; Li Cheng Ping; Wu Kun; Zeng Yun

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Huang Ying , Liu Yi Han , Li Cheng Ping , Wu Kun , Zeng Yun . Expression of IL-17 and IL-23 in Patients with B-cell non-HodgkinLymphoma Treated by RCHOP[J]. Journal of Kunming Medical University, 2016, 37(12): 76-81.

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Huang Ying , Liu Yi Han , Li Cheng Ping , Wu Kun , Zeng Yun . Expression of IL-17 and IL-23 in Patients with B-cell non-HodgkinLymphoma Treated by RCHOP[J]. Journal of Kunming Medical University, 2016, 37(12): 76-81.

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Expression of IL-17 and IL-23 in Patients with B-cell non-HodgkinLymphoma Treated by RCHOP

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基金：云南省教育厅科学研究基金资助项目(2013Y292);

Received Date: 2016-08-29

Abstract

Abstract

Objectives To study the role of IL-17 and IL-23 in non-Hodgkin lymphoma(NHL) by detecting the expression levels of IL-17 and IL-23 in peripheral blood of B-cell non-Hodgkin lymphoma patients treated by RCHOP.Methods T wenty-five patients with B-cell NHL who achieved remission after 6 to 8 cycles of R-CHOP as a NHL group,20 healthy volunteers were recruited as a normal control group.RT-PCR was used to detect the expression levels of IL-17 m RNA and IL-23 m RNA in NHL patients and health volunteers.Results The expression level of IL-17 m RNA and IL-23 m RNAin the patients with NHL before therapy and the patients with NHL who achieved remission was lower than that in the normal control group(P<0.05).The expression level of IL-17 m RNA and IL-23 m RNA in the patients with NHL who achieved remission was higher than that in the patients with NHL before therapy(P=0.001,P<0.05).Conclusion IL-17 and IL-23 m RNA expressions are higher after treated with R-CHOP.The expression levels of IL-17 m RNA and IL-23 m RNA in NHL patients are related with prognosis and efficacy.
- Non-Hodgkin lymphoma,
- Interleukin-17,
- Interleukin-23,
- Rituximab,
- Prognosis

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References(19)

References

[1]	[1]SIEGEL R L,MILLER K D,JEMAL A.Cancer statistics[J].CA Cancer J Clin,2015,65(1):5-29.
[2]	[2]STASICR,DELPOETAG,STIPAE,et al.Response to B-cell depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura[J].Blood,2007,110(8):2924-2930.
[3]	[3]STASI R,COOPERN,DELPOETAG,et al.Analysis of regulatory T-cell changes in patients with idiopathic throm bocytopenic purpura receiving B cell-depleting therapy with rituximab[J].Blood,2008,112(4):1147-1150.
[4]	[4]SHAHRARAS,HUANGQ,MANDELINAM,et al.TH-17cells in rheumatoid arthritis[J].Arthritis Res Ther,2008,10(4):R93.
[5]	[5]RACKEMK.Immunopathogenesis of multiple sclerosis[J].Ann Indian Acad Neurol,2009,12(4):215-220.
[6]	[6]ZHOU L,LITTMANDR.Transcriptional regulatory net works in Th17 cell differentiation[J].Curr Opin Im munol,2009,21(2):146-152.
[7]	[7]STARK M A,HUO Y,BURCIN T L,et al.Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23and IL-17[J].Immunity,2005,22(3):285-294.
[8]	[8]TZANKOVA,MEIERC,HIRSCHMANNP,et al.Correla tion of high numbers of intratumoral FOXP3+regulatory T cells with improved survival in germinal center like diffuse large B-cell lymphoma,follicular lymphoma and classical Hodgkin's lymphoma[J].Haematologica,2008,93(2):193-200.
[9]	[9]GHILARDIN,OUYANGW.Targeting the development and effector functions of TH17 cells[J].Semin Immunol,2007,19(6):383-393.
[10]	[10]SAKAGUCHIS.Regulatory T cells:key controllers of immuno logicself-tolerance[J].Cell,2000,101(5):455-458.
[11]	[11]PARK H,LI Z,YANG X O,et al.A distinct lineage of CD4 T cells regulates tissue inflammation by producing inter leukin 17[J].Nat Immunol,2005,6(11):1133-1141.
[12]	[12]OPPMANNB,LESLEYR,BLOMB,et al.Novel p19 pro tein engages IL-12p40 to form a cytokine from a cytokine,IL-23,with biological activities similar as well as distinct from IL-12[J].Immunity,2000,13(5):715-725.
[13]	[13]LU T,YUS,LIUY,et al.Aberrant Circulating Th17 Cells in Patients with B-Cell Non-Hodgkin’s Lymphoma[J].PLo S One,2016,11(1):e0148044.
[14]	[14]CARRERAS J,LOPEZ-GUILLERMO A,FOXBC,et al.High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicu lar lymphoma[J].Blood,2006,108(9):2957-2964.
[15]	[15]VAN D E VEERDONKFL,LAUWERYSB,MARIJNIS SENRJ,et al.The anti-CD20 antibody rituximab reduces the Th17 cell response[J].Arthritis Rheum,2011,63(6):1507-1516.
[16]	[16]The International Non-Hodgkin’s Lymphoma Prognostic Factors Project.A predictive model for aggressive non-Hodgkin’s lymphoma[J].N Engl J Med,1993,329(14):987-994.
[17]	[17]KIKLY K,LIU L,NA S,et al.The IL-23/Th(17)axis:therapeutic targets for autoimmune inflammation[J].Curr Opin Immunol,2006,18(6):670-675.
[18]	[18]LANGOWSKI J L,ZHANG X,WU L,et al.IL-23promotes tumour incidence and growth[J].Nature,2006,442(7101):461-465.
[19]	[19]STANILOV N,MITEVA L,MINTCHEV N,et al.High expression of Foxp3,IL-23p19 and survivin m RNA in colorectal carcinoma[J].Int J Colorectal Dis,2009,24(2):151-157.

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