Effect of Probiotics on Blood Lipid Metabolism of Elderly Patients with Coronary Heart Disease

Li Wen Hua; Wei Yun Hong; Ye Ji Yun

Article Contents

Article Navigation > Journal of Kunming Medical University > 2016 > 37(12): 82-84

Li Wen Hua , Wei Yun Hong , Ye Ji Yun . Effect of Probiotics on Blood Lipid Metabolism of Elderly Patients with Coronary Heart Disease[J]. Journal of Kunming Medical University, 2016, 37(12): 82-84.

Citation:

Li Wen Hua , Wei Yun Hong , Ye Ji Yun . Effect of Probiotics on Blood Lipid Metabolism of Elderly Patients with Coronary Heart Disease[J]. Journal of Kunming Medical University, 2016, 37(12): 82-84.

Li Wen Hua , Wei Yun Hong , Ye Ji Yun . Effect of Probiotics on Blood Lipid Metabolism of Elderly Patients with Coronary Heart Disease[J]. Journal of Kunming Medical University, 2016, 37(12): 82-84.

Citation:

PDF( 130 KB)

Effect of Probiotics on Blood Lipid Metabolism of Elderly Patients with Coronary Heart Disease

Funds:

基金：云南省科技计划基金资助项目(2010ZC200);

Received Date: 2016-08-29

Abstract

Abstract

Objective To investigate the effect of probiotics on the blood lipid metabolism of elderly patients with coronary artery disease(CHD).Methods The clinical data of 100 elderly CHD patients who were admitted in our hospital from May 2012 ~November 2015 were collected.The enrolled patients were randomly divided into observation group and control group, 50 cases in each group.All patients were routinely given medication for secondary prevention of CHD,patients in the observation group were additionally given oral probiotics.Then we observed the changes in the lipid levels of patients before and after 12 weeks treatment.Results The serum total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C) of patients in the observation group were improved more significantly than the control group,the difference was significant(P<0.05).The serum total High-density lipoprotein cholesterol(HDL-C) was improved more significantly than the control group.Conclusion Probiotics adjuvant therapy can significantly improve the blood lipid indexes in elderly CHD patients.
- Coronary heart disease,
- Probiotics,
- Lipid metabolism

FullText(HTML)

References(16)

References

[1]常露,赵珍,朱振东,等.两种高脂饲料分段喂养对大鼠体重和血脂的影响[J].昆明医科大学学报,2015,36(8):19-22.
[2]	[2]MURRAY C J,LOPEZ A D.Mortality by cause for eight regions of the world:Global burden of disease study[J].Lancet,1977,349(61):126-127.
[3]朱春频.他汀类药物治疗冠心病合并高脂血症的效果分析[J].中西医结合心脑血管病杂志,2012,9(2):26-29.
[4]	[4]RESTASC.Effects of probiotics and commensals on intestional epithelial.physiology:implications for nutrient handing[J].J Physiol,2009,587(17):416-417.
[5]	[5]ATTENCE-RAMOS M S,NAVAGM,MUELLNERMG,et al.DNA damage and toxicogenomic analyses of hydrogen sulfide in human intestinal epithelial FH3 74 Int cells[J].Environ Mol Mutagen,2010,51(4):304-314.
[6] 许东,李敏,王建成,等.老年人肠道菌群与肠道粘膜免疫相关性分析[J].中华老年医学杂志,2009,28(7):577-579.
[7]	[7]WANG Z,XIAOG,YAOY,et al.The role of bifidobacteria in gutbarrier function after thermal injury in rats[J].J Trauma,2006,61(3):650-657.
[8]	[8]EVERARDA,LAZAREVICV,DERRIENM,et al.Responses of gut mierobiota and glucose and Lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant.mice[J].Diabetes,2011,60(11):2775-2786.
[9]张胜利.微生态制剂联合谷氨酰胺在肝硬化失代偿治疗中的疗效观察[J].中国现代医学杂志,2010,12(10):95-97.
[10]	[10]REIFFC,KELLYD.Inflammatory bowel disease,gut bacteria and probiotic therapy[J].Int J Med Microbiol,2010,300(1):25-33.
[11]伏忠阳,李亚雄,郭明.阿托伐他汀联合曲美他嗪治疗冠心病临床疗效观察[J].云南医药,2016,37(1):65-66.
[12]伏忠阳,易婧,郭明.冠心病患者自我保健方法的研究[J].云南医药,2015,36(1):5-7.
[13]脂联素与冠心病的研究进展[J].云南医药,2013,58(1):69-73.
[14]张晓磊,武岩峰,宋秋梅,等.益生菌降血脂作用的研究进展[J].中国乳品工业,2015,43(5):27-31,64.
[15]孙煜,孙良阁.肠道益生菌对慢性代谢性疾病的影响及展望[J].河南医学研究,2014,23(1):147-149.
[16]宋明鑫,许丽,王文梅,等.乳酸菌降解胆固醇的作用机理及其在动物中的研究现状[J].饲料工业,2011,32(22):48-51.

Relative Articles(20)

Relative Articles

[1]	Shuangshuang XU, Wei ZHAO, Lei JIANG, Huajiang LIU, Fang WANG, Zhisheng TAN, Likun ZHOU. Correlation Between TyG Index，MHR and Coronary Lesions，Myocardial Ischemia in Patients with Coronary Heart Disease，and the Value of Combined Detection. Journal of Kunming Medical University, 2024, 45(3): 65-71. doi: 10.12259/j.issn.2095-610X.S20240310
[2]	Guojing LIANG, Kun JI, Kaichun ZHANG, Yufang ZHANG, Jing AN, Yuge ZHANG, Juan WEN, Haiyan REN. The Effect of Probiotics on the Expression of Aβ and the Protective Effect of Neurons in Rats with Cerebral Ischemia-Reperfusion Injury. Journal of Kunming Medical University, 2024, 45(5): 37-43. doi: 10.12259/j.issn.2095-610X.S20240506
[3]	Leijing RAN, Shaohua WANG, Lintong LI, Li GUI. A Meta-analysis of the Effect of Adjuvant Probiotics in Patients with Osteoporosis. Journal of Kunming Medical University, 2024, 45(2): 65-76. doi: 10.12259/j.issn.2095-610X.S20240209
[4]	Wenqing MIAO, Yu WANG, Xiaoli ZHAO, Nini TIAN, Liying YOU. Analysis of Differential Gene Expression and Function in Peripheral Blood of Patients with Coronary Heart Disease and Acute Myocardial Infarction. Journal of Kunming Medical University, 2022, 43(6): 25-34. doi: 10.12259/j.issn.2095-610X.S20220614
[5]	Jing TANG, Jun-chao HUANG, Ya-fei HUANG, Ming-zhu GENG, Xiao-qin MAO, Jian-ping PU. Application of Lipoprotein-associated Phospholipase A2 in Coronary Heart Disease Patients Taking Statins. Journal of Kunming Medical University, 2021, 42(12): 6-10. doi: 10.12259/j.issn.2095-610X.S20211205
[6]	Bin LIU, Xian-gang LI, Min ZHANG, Fang ZHOU, Ren-hua LIN, Jie YANG, Liang ZHANG, Xian-kun WANG, Ya-nan PAN. Main Influencing Factors of the Second Hospitalization of Patients with Coronary Heart Disease. Journal of Kunming Medical University, 2021, 42(6): 103-109. doi: 10.12259/j.issn.2095-610X.S20210618
[7]	Xing LIU, Hai-wen LI, Hong-li HUANG, Lin-jun SHEN, Le ZHANG, Xiang-fang LIU, Wen-lin ZHANG, Lu WANG. Effects of Probiotics Enhanced Enteral Nutrition on Gastrointestinal Function and Cytokines in Patients with Severe Acute Pancreatitis. Journal of Kunming Medical University, 2021, 42(11): 81-86. doi: 10.12259/j.issn.2095-610X.S20211116
[8]	Ze-xi LIN, Li-qing LIN, Jian-ren WANG, Tao XIE, Xi-an FU, Jun PU. Effects of Probiotics Enteral Nutrition on Ventilator Associated Pneumonia in Patients with Severe Brain Injury. Journal of Kunming Medical University, 2021, 42(12): 17-22. doi: 10.12259/j.issn.2095-610X.S20211213
[9]	Dai Hai Long , Zhang Xing , Pan Yun , Feng Xiao Lan , Lu Xiang Ting , Guang Xue Feng , Yin Xiao Long . . Journal of Kunming Medical University, 2020, 41(04): 60-63.
[10]	Xu XU, Li-yong WU, Ming-li ZHOU, Guo-fu ZHU. Relationship between microRNA-146a and the Plaque Stability in Coronary Heart Disease Patients. Journal of Kunming Medical University, 2020, 41(11): 56-61. doi: 10.12259/j.issn.2095-610X.S20201119
[11]	Wang Ji Yan , Duan Yong . . Journal of Kunming Medical University, 2018, 39(12): 1-4.
[12]	Li Lin , Li Ji Yi , Wang De Zhao , Liu Wei . 武汉地区123例冠心病患者CYP2C19基因多态性分布. Journal of Kunming Medical University, 2017, 38(06): 60-63.
[13]	Xiao Yi . The Clinical Effect of CDSP Treatment for Coronary Heart Disease. Journal of Kunming Medical University,
[14]	Feng Yong Hong . . Journal of Kunming Medical University,
[15]	Li Hong Dao . . Journal of Kunming Medical University,
[16]	Tan Xiao Bing . . Journal of Kunming Medical University,
[17]	Yang Ping . . Journal of Kunming Medical University,
[18]	Zhou Kai Hua . . Journal of Kunming Medical University,
[19]	Yin Lin . . Journal of Kunming Medical University,
[20]	Lv Han Xian . Detection of Periodontopathogens in Subgingival Plaque of Patients with Coronary Heart Disease and Periodontitis. Journal of Kunming Medical University,