Volume 37 Issue 01
. 
Turn off MathJax
Article Contents
Abstract
References
Relative Articles
Article Navigation >  Journal of Kunming Medical University  > 2016  >  37(01): 
Jiping ZHOU, Junling ZHANG, Qing LIU, Xingmei LI, Peiyou FAN, Heling JIANG. The Application of “Modular Teaching Method” in the Nursing Teaching of Nephrology Department[J]. Journal of Kunming Medical University, 2022, 43(5): 168-172. doi: 10.12259/j.issn.2095-610X.S20220523
Citation: Zhang Ying . Impacts of Clostridium，Montmorillonite Powder and Mesalazine on Treg and Th17 in Rats with UC[J]. Journal of Kunming Medical University, 2016, 37(01).
shu

Impacts of Clostridium，Montmorillonite Powder and Mesalazine on Treg and Th17 in Rats with UC

  • (1)Dept. of Pediatrics,The 1rst Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032;2)Dept. of Pediatrics,Bai Autonomous Prefecture of Dali Prefecture People’s Hospital,Dali Yunnan 671000,China)

    Abstract
  • ［Abstract］Objective　To study the impacts of clostridium，montmorillonite powder and mesalazine on Regulative T Cells （Treg）/ Auxilliary T-17 Cells（ Th17 ）immune balance in rats with ulcerative colitis （UC ）induced by 2，4，6 TNBS/ethanol. Methods　48 rats were divided randomly into 6 groups（8 rats per group） including the model，clostridium，montmorillonite，mesalazine，mesalazine plus montmorillonite and normal group. TNBS/ethanol was used to build a model of rats with UC. The quantity of normal saline， clostridium，montmorillonite powder and mesalazine were converted by surface area of rat and given the rats by gastro-tube daily.4 rats were executed on the 5th day after the molded and treatment， Other rats were executed on the 12th day after the molded and treatment，and the blood samples were collected to measure the contents of Treg and Th17 by a flow cytometer and observe the Treg/Th17 ratios．Results（1）The levels of Treg in normal group and the model group were markedly higher than in clostridium，montmorillonite，mesalazine and mesalazine plus montmorillonite group on the fifth day， differences are statistically.（P＜0.05）However， this result reversed dramaticly on the 12th day， which were more lower， especially in clostridium group.Significant difference appeared except the mesalazine group（P＜0.01）；Statistically comparing the 12th day with the 5th day in the treatment， Treg values all rised tremendously ，excluded the normal group and the model group.（2）The level of Th17 in normal group was obviously more lower than in other 5 groups on the 5th and 12th day， apparently more lower than in the model group.The differences have statistic significance（P＜0.05）；Statistically comparing the 12th day with the 5th day in the treatment，the Th17 value decreased apparently in the other 4 groups excluded the montmorillonite and clostridium group，differences were statistically significant（P＜0.05）．（3）The ratio of Treg/Th17 in normal group was obviously more higher than other 5 groups on the 5th and 12th day， apparently higher than in the model group. （P＜0.05）But on the 12th day， the ratios of Treg/Th17 in clostridium，montmorillonite， mesalazine and mesalazine plus montmorillonite group were gradually close to normal group， especially in mesalazine plus montmorillonite group，（P＜0.05）while the model group still keeps lower level，Statistically comparing the 12th day with the fifth day in the treatment，all the ratio of Treg/Th17 rised（P＜0.05）．Conclusions（1）The immune imbalance of Treg/Th17 might play a important role in UC pathogenesis. （2）Clostridium，montmorillonite，and mesalazine could effectively restrain or reduce the level of Th17 and elevate the level of Treg in rats with UC model to prevent inflammatory reaction and shorten the duration of inflammation.
    • FullText(HTML)
    • References(0)
    • Relative Articles(20)

  • Relative Articles

    [1] Chunyan LIU, Bingqing CHANG, Chao LI, Xin REN, Xiaoqin LIU. Correlations between CD4+CD25+Treg，sCD30 and Clinical Characteristics of Lymphoma and Their Value in Predicting Infection after Chemotherapy. Journal of Kunming Medical University, 2025, 46(1): 142-147.  doi: 10.12259/j.issn.2095-610X.S20250121
    [2] Chunling LI, Linghua LI, Xu HAN, Jie YANG, Heng ZHANG. Clinical Observation of Treating Ulcerative Colitis with Acupuncture at Front Mu Points Combined with Oral Mesalazine. Journal of Kunming Medical University, 2024, 45(3): 72-78.  doi: 10.12259/j.issn.2095-610X.S20240311
    [3] Chenglin YANG, Jie HU, Jing WANG, Minhua WANG, Ling HUANG. Clinical Correletions between Helper T Cells 17，Regulatory T Cells and Chronic Actinic Dermatitis. Journal of Kunming Medical University, 2023, 44(5): 95-101.  doi: 10.12259/j.issn.2095-610X.S20230511
    [4] Yiyin QU, Siyuan ZHENG, Chunyu DAI, Yi ZHANG. Impact of Acute Non-normovolemic Hemodilution on Perioperative NK Cell, NKT cell and Th1/Th2 in Elderly Patients Undergoing Rectal Carcinoma Radical Resection. Journal of Kunming Medical University, 2022, 43(2): 128-133.  doi: 10.12259/j.issn.2095-610X.S20220225
    [5] Yuxiao LI, Ming HE, Tianrong WANG, Yonggang YAO, Yu WANG. In Vitro Regulation of Th1/Th2 Cell of PBMCs in AR Mice by si-GATA-3. Journal of Kunming Medical University, 2022, 43(8): 7-16.  doi: 10.12259/j.issn.2095-610X.S20220802
    [6] Le ZHAN, Ruiyu MA, Ni WAN, Liwen MO, Huiying CHEN, Li ZHANG. Effects of Puerarin on Th17/Treg Cell Immune Homeostasis and the Expression of Related Transcription Factors in Rats with Periodontitis. Journal of Kunming Medical University, 2022, 43(11): 36-43.  doi: 10.12259/j.issn.2095-610X.S20221129
    [7] Guo-yi LIU, Qing-qing ZHAO, Yan WU, Shan-shan LI, Lian-mei ZHONG, Jia GENG. Effect and Mechanism of Puerarin on Experimental Autoimmune Encephalomyelitis in Mice. Journal of Kunming Medical University, 2021, 42(4): 1-7.  doi: 10.12259/j.issn.2095-610X.S20210401
    [8] Fang WANG, Rong ZHAO, Hong ZHENG. Clinical Effect of Kan Fu Xin Combined with Montmorillonite on the Prevention and Treatment of Radiation-induced Oral Mucositis in Patients with Head and Neck Cancer. Journal of Kunming Medical University, 2021, 42(6): 98-102.  doi: 10.12259/j.issn.2095-610X.S20210626
    [9] Long Jun Jun , Li Lan . . Journal of Kunming Medical University, 2019, 40(11): 152-155.
    [10] Chai Lin , Zhang Jun , Li Yun Fen , Liu Rong Jun . . Journal of Kunming Medical University, 2019, 40(11): 127-130.
    [11] Huang Yu , Liu Ying . . Journal of Kunming Medical University, 2019, 40(06): 125-128.
    [12] Yang Jing . . Journal of Kunming Medical University,
    [13] Yang Jing . . Journal of Kunming Medical University,
    [14] Sun Yi. . Journal of Kunming Medical University,
    [15] Li Xiao Yong . . Journal of Kunming Medical University,
    [16] Li Hong Li . . Journal of Kunming Medical University,
    [17] Su Ying . . Journal of Kunming Medical University,
    [18] Li Cong Mei . . Journal of Kunming Medical University,
    [19] Hu Wan Qin . . Journal of Kunming Medical University,
    [20] Wang Juan Li . . Journal of Kunming Medical University,
    • Supplements(0)
    • Cited By

  • Cited by

    Periodical cited type(11)

    1. 薛占成，韩海燕，刘冀琴，周秀. 机化性肺炎患者T淋巴细胞亚群分析的临床意义. 实用检验医师杂志. 2023(02): 185-188 .
    2. 付春芳，赵鑫. 肺结核患者检测免疫功能指标及血清PCT、PA的临床意义探讨. 中国实用医药. 2022(10): 104-106 .
    3. 郑树斌，陈天杨，陈欣羽，刘孟珂. 肺泡灌洗液中T淋巴细胞亚群水平对于肺结核诊断和疗效判断的Meta分析. 临床医学研究与实践. 2021(01): 15-18+22 .
    4. 何晗，唐柳生，李世立，董捷，周游，韦显珍. 青年肺结核患者支气管肺泡灌洗液T淋巴细胞亚群及炎症因子测定价值分析. 右江医学. 2020(09): 686-690 .
    5. 吴雪琼. 淋巴细胞亚群检测及对结核病诊断和患者免疫状况评价的价值. 中国防痨杂志. 2020(10): 1020-1024 .
    6. 冯睿婷，赵继智. 肺结核患者血清T淋巴细胞亚群检测流式细胞术的应用. 内蒙古医学杂志. 2020(10): 1190-1191 .
    7. 张丽柯，杨卫，史芳瑜，徐全晓. 流式细胞仪淋巴亚群在肿瘤化学治疗后患者中的应用效果. 实用医技杂志. 2019(04): 445-447 .
    8. 庞凡，仲燕，刘雅. 肺结节病患者支气管肺泡灌洗液及外周血中T淋巴细胞亚群水平检测的意义. 检验医学与临床. 2019(20): 3013-3015 .
    9. 杨秀丽. 化疗联合艾迪注射液对晚期肺癌患者瘤体变化及免疫功能的影响. 中国中医基础医学杂志. 2018(02): 222-225 .
    10. 李昱，杨庚. 白细胞介素12对耐药结核大鼠模型的影响. 中国医药生物技术. 2018(01): 54-58 .
    11. 李芹，张静. 肺结节病患者T淋巴细胞亚群检测的诊断价值. 宁夏医学杂志. 2018(10): 944-945 .

    Other cited types(3)

  • Created with Highcharts 5.0.7Amount of accessChart context menuAbstract Views, HTML Views, PDF Downloads StatisticsAbstract ViewsHTML ViewsPDF Downloads2024-052024-062024-072024-082024-092024-102024-112024-122025-012025-022025-032025-04050100150200
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 45.4 %FULLTEXT: 45.4 %META: 52.2 %META: 52.2 %PDF: 2.4 %PDF: 2.4 %FULLTEXTMETAPDF
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 5.4 %其他: 5.4 %其他: 0.1 %其他: 0.1 %Canton: 0.1 %Canton: 0.1 %China: 0.3 %China: 0.3 %Falkenstein: 0.6 %Falkenstein: 0.6 %Girard: 0.2 %Girard: 0.2 %Seattle: 0.1 %Seattle: 0.1 %上海: 0.4 %上海: 0.4 %丽江: 0.2 %丽江: 0.2 %亳州: 0.1 %亳州: 0.1 %保定: 0.1 %保定: 0.1 %保山: 0.5 %保山: 0.5 %六安: 0.2 %六安: 0.2 %兰州: 0.3 %兰州: 0.3 %内江: 0.1 %内江: 0.1 %北京: 28.1 %北京: 28.1 %十堰: 0.7 %十堰: 0.7 %南京: 0.6 %南京: 0.6 %南昌: 0.2 %南昌: 0.2 %台州: 0.1 %台州: 0.1 %呼和浩特: 0.1 %呼和浩特: 0.1 %哥伦布: 0.3 %哥伦布: 0.3 %嘉兴: 0.6 %嘉兴: 0.6 %大理: 0.2 %大理: 0.2 %天津: 0.9 %天津: 0.9 %太原: 0.4 %太原: 0.4 %宁波: 0.2 %宁波: 0.2 %安康: 0.1 %安康: 0.1 %宣城: 0.8 %宣城: 0.8 %宿州: 0.1 %宿州: 0.1 %常州: 0.4 %常州: 0.4 %常德: 0.1 %常德: 0.1 %广州: 0.1 %广州: 0.1 %张家口: 4.7 %张家口: 4.7 %恩施: 0.1 %恩施: 0.1 %悉尼: 0.3 %悉尼: 0.3 %成都: 0.2 %成都: 0.2 %扬州: 0.8 %扬州: 0.8 %无锡: 0.2 %无锡: 0.2 %昆明: 2.5 %昆明: 2.5 %朝阳: 0.1 %朝阳: 0.1 %杭州: 1.4 %杭州: 1.4 %柳州: 0.1 %柳州: 0.1 %武汉: 0.1 %武汉: 0.1 %沈阳: 0.2 %沈阳: 0.2 %泉州: 0.1 %泉州: 0.1 %波士顿: 0.1 %波士顿: 0.1 %济南: 0.2 %济南: 0.2 %淄博: 0.1 %淄博: 0.1 %深圳: 0.6 %深圳: 0.6 %温州: 0.5 %温州: 0.5 %湖州: 0.1 %湖州: 0.1 %湘西: 0.1 %湘西: 0.1 %漯河: 3.5 %漯河: 3.5 %玉溪: 0.1 %玉溪: 0.1 %石家庄: 0.6 %石家庄: 0.6 %福州: 0.4 %福州: 0.4 %纽约: 0.2 %纽约: 0.2 %绵阳: 0.1 %绵阳: 0.1 %芒廷维尤: 15.2 %芒廷维尤: 15.2 %芝加哥: 1.1 %芝加哥: 1.1 %茂名: 0.1 %茂名: 0.1 %衡水: 0.1 %衡水: 0.1 %衡阳: 0.1 %衡阳: 0.1 %衢州: 0.1 %衢州: 0.1 %襄阳: 0.2 %襄阳: 0.2 %西宁: 10.5 %西宁: 10.5 %西安: 0.2 %西安: 0.2 %诺沃克: 0.6 %诺沃克: 0.6 %贵阳: 0.2 %贵阳: 0.2 %赣州: 0.1 %赣州: 0.1 %辽源: 0.1 %辽源: 0.1 %运城: 0.2 %运城: 0.2 %遵义: 0.1 %遵义: 0.1 %邯郸: 0.1 %邯郸: 0.1 %郑州: 9.9 %郑州: 9.9 %重庆: 0.5 %重庆: 0.5 %金华: 0.2 %金华: 0.2 %铁岭: 0.3 %铁岭: 0.3 %银川: 0.1 %银川: 0.1 %镇江: 0.2 %镇江: 0.2 %长春: 0.1 %长春: 0.1 %长沙: 0.4 %长沙: 0.4 %驻马店: 0.1 %驻马店: 0.1 %其他其他CantonChinaFalkensteinGirardSeattle上海丽江亳州保定保山六安兰州内江北京十堰南京南昌台州呼和浩特哥伦布嘉兴大理天津太原宁波安康宣城宿州常州常德广州张家口恩施悉尼成都扬州无锡昆明朝阳杭州柳州武汉沈阳泉州波士顿济南淄博深圳温州湖州湘西漯河玉溪石家庄福州纽约绵阳芒廷维尤芝加哥茂名衡水衡阳衢州襄阳西宁西安诺沃克贵阳赣州辽源运城遵义邯郸郑州重庆金华铁岭银川镇江长春长沙驻马店

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (2462) PDF downloads(98) Cited by(14)
    Proportional views
    Related

    Copyright © 《昆明医科大学学报》编辑部  滇ICP备00000000号-0

    Publishing: 昆明医科大学学报编辑部

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return