The Correlation between Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus of the Han Nationality in Kunming Region

Du Si Cheng

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Du Si Cheng . The Correlation between Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus of the Han Nationality in Kunming Region[J]. Journal of Kunming Medical University, 2016, 37(02).

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Du Si Cheng . The Correlation between Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus of the Han Nationality in Kunming Region[J]. Journal of Kunming Medical University, 2016, 37(02).

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The Correlation between Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus of the Han Nationality in Kunming Region

Du Si Cheng

(1)Dept. of Gerontology,The First Affiliated Hospital of Kunming Medical University;2)Diabetes Department;3)Clinical Laboratory Department,Kunming Yunnan 650032,China)

Abstract

Abstract

［Abstract］Objective　To explore the correlation between vitamin D receptor （VDR） gene polymorphism and type 2 diabetes mellitus of the Han nationality in Kunming region. Methods　One-hundred-twenty-six Kunming individuals（90 T2DMs and 36 controls）were enrolled in this randomized controlled trial. rs7975232 single nucleotide polymorphism （SN+J8Ps） of the VDR was tested by using Polymerase chain reaction of restriction fragment length polymorphism（PCR-RFLP）， the genotype and its frequencies were compared between the two groups．Results（1）There were statistically significant association in three kinds of genotype of ApaI of VDR gene polymorphism between two groups（P＜0.001）. The C/A genotype was more common in T2DM patients （62.2% vs 38.9%）. （2）Statistic analysis software showed that the frequency of C/A genotype of ApaI was higher than that in the control group（OR=1.36， 95%CI: 0.54-1.71）. Whats more， age in T2DM group were also higher than that in the control group（OR= 1.09，95% CI: 1.03-1.18 ）. 25OHD3 in T2DM group was lower than that in the control group （OR=0.84，95%CI:0.73-0.93），suggesting that C/A genotype and age are risk factors of T2DM. Meanwhile 25OHD3 may be a preventive factor of T2DM．Conclusions（1）There is a significant correlation between C/A genotype of rs7875232 and the prevalence of T2DM of the Han nationality in Kunming region.（2）25OHD3 is a protective factor of T2DM and the aging is a risk factor of T2DM.
- ［Key words］Diabetes mellitus； Type 2；Vitamin D receptor gene； Polymorphism；Polymerase chain reaction of restriction fragment length polymorphism,

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