Volume 37 Issue 02
. 
Turn off MathJax
Article Contents
Abstract
References
Relative Articles
Article Navigation >  Journal of Kunming Medical University  > 2016  >  37(02): 
An Yuan . Effect of Blood Purification on Septic Encephalopathy Neuron-specific Enolase[J]. Journal of Kunming Medical University, 2016, 37(02).
Citation: Du Si Cheng . The Correlation between Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus of the Han Nationality in Kunming Region[J]. Journal of Kunming Medical University, 2016, 37(02).
shu

The Correlation between Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus of the Han Nationality in Kunming Region

  • (1)Dept. of Gerontology,The First Affiliated Hospital of Kunming Medical University;2)Diabetes Department;3)Clinical Laboratory Department,Kunming Yunnan 650032,China)

    Abstract
  • ［Abstract］Objective　To explore the correlation between vitamin D receptor （VDR） gene polymorphism and type 2 diabetes mellitus of the Han nationality in Kunming region. Methods　One-hundred-twenty-six Kunming individuals（90 T2DMs and 36 controls）were enrolled in this randomized controlled trial. rs7975232 single nucleotide polymorphism （SN+J8Ps） of the VDR was tested by using Polymerase chain reaction of restriction fragment length polymorphism（PCR-RFLP）， the genotype and its frequencies were compared between the two groups．Results（1）There were statistically significant association in three kinds of genotype of ApaI of VDR gene polymorphism between two groups（P＜0.001）. The C/A genotype was more common in T2DM patients （62.2% vs 38.9%）. （2）Statistic analysis software showed that the frequency of C/A genotype of ApaI was higher than that in the control group（OR=1.36， 95%CI: 0.54-1.71）. Whats more， age in T2DM group were also higher than that in the control group（OR= 1.09，95% CI: 1.03-1.18 ）. 25OHD3 in T2DM group was lower than that in the control group （OR=0.84，95%CI:0.73-0.93），suggesting that C/A genotype and age are risk factors of T2DM. Meanwhile 25OHD3 may be a preventive factor of T2DM．Conclusions（1）There is a significant correlation between C/A genotype of rs7875232 and the prevalence of T2DM of the Han nationality in Kunming region.（2）25OHD3 is a protective factor of T2DM and the aging is a risk factor of T2DM.
    • FullText(HTML)
    • References(0)
    • Relative Articles(20)

  • Relative Articles

    [1] Congxin LI, Haidong YUE, Pengxi ZHU, Guangxian HUANG, Lingjie MU, Yanan PENG, Yijie WANG, Yang YANG. Correlation Analysis between Different Vitamin D3 Levels and Immune Inflammatory Indicators in Elderly Patients with Sepsis. Journal of Kunming Medical University, 2025, 46(2): 51-58.  doi: 10.12259/j.issn.2095-610X.S20250208
    [2] Sixiang LIU, Yongkun HUANG, Shulan SHI, Jingjing SUN, Lisi LUO, Li WANG, Yu LING. Analysis of Vitamin D in Children with Henoch-Schonlein Purpura. Journal of Kunming Medical University, 2024, 45(1): 133-135.  doi: 10.12259/j.issn.2095-610X.S20240122
    [3] Linxia LI, Yanhong LI, Jie WU, Lili ZHANG, Xian ZHANG, Song WANG, Juntao ZHANG, Peng YAN. Studies on the Correlation between Serum Vitamin A, D and Lung Function in Infants with Asthmatic Pneumonia. Journal of Kunming Medical University, 2022, 43(1): 63-66.  doi: 10.12259/j.issn.2095-610X.S20220114
    [4] Yong YUAN, Xinyi LI, Yan FU, Yan ZHU. Analysis of Vitamin D Level in Pregnant Women and Infants in Kunming and Study on the Relationship between Fasting Blood Glucose Level and Vitamin D Level during Pregnancy. Journal of Kunming Medical University, 2022, 43(9): 125-129.  doi: 10.12259/j.issn.2095-610X.S20220931
    [5] Ying ZHAO, Yandan SU, Ruizhu TANG, Yong DUAN, Wenping SHAO. Vitamin D Status of 2563 Subjects in Kunming. Journal of Kunming Medical University, 2022, 43(4): 19-25.  doi: 10.12259/j.issn.2095-610X.S20220405
    [6] Xiao-rui YANG, Qian XIANG, Ya QIU, Yan LUAN, Xian ZHANG, Yan GUO. Correlation between Serum 25-hydroxyvitamin D and Peripheral Neuropathy in Type 2 Diabetes. Journal of Kunming Medical University, 2021, 42(7): 88-93.  doi: 10.12259/j.issn.2095-610X.S20210714
    [7] Ling NIU, Bo-yi LI, Jing-qiu MAO, Yan TANG, Rong MA, Fang LIU, Chen ZHANG, Zhu-jun HAN, Cui-juan MIAO, Xian ZHANG. The Relationship between Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area. Journal of Kunming Medical University, 2021, 42(7): 70-76.  doi: 10.12259/j.issn.2095-610X.S20210711
    [8] Ling NIU, Bo-yi LI, Cheng ZHANG, Rong MA, Yan TANG, Fang LIU, Li-min YIN, Zhu-jun HAN, Cui-juan MIAO, Xian ZHANG. Relationship between Calcitonin Receptor，Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area. Journal of Kunming Medical University, 2021, 42(11): 74-80.  doi: 10.12259/j.issn.2095-610X.S20211114
    [9] Xiao-hui RUAN, Qian XIANG, Yu-ming WANG, Zhi-han ZHOU, Xian ZHANG, Yan GUO, Xiao-rui YANG. The Correlation between Vitamin D Receptor Gene Bg1I and Cdx-2 Polymorphism and Hashimoto’ s Thyroiditis. Journal of Kunming Medical University, 2021, 42(8): 132-139.  doi: 10.12259/j.issn.2095-610X.S20210824
    [10] Zhang Li Li , Zhao Lin , Li Yan Hong , Wu Jie , Zheng Wen Jing , Shang Xiao Li . . Journal of Kunming Medical University, 2020, 41(08): 126-133.
    [11] Liu Yu Jiao , Li Qi . The Correlation between Vitamin D Receptor Gene Polymophism and Bone Metabolism Disorder in Children with Nephrotic Syndrome. Journal of Kunming Medical University, 2018, 39(02): 55-59.
    [12] Li Yan Hong , Zhang Xian , Zhang Jun Tao , Zhao Meng Ru , Tang Jia Hui , Li Lin Xia . . Journal of Kunming Medical University, 2018, 39(11): 67-73.
    [13] Xiang Xi , Wang Yu Ming , Yang Yan Run , Li Wan Bi , Zhang Xian , Yang Cai , Liu Hua . The Relationship between Vitamin D Receptor (VDR) Gene ApaI, FokI, TaqI, Tru9I Single Nucleotide Polymorphism and Hashimoto's Thyroiditis. Journal of Kunming Medical University, 2018, 39(04): 88-94.
    [14] Cui Kun Hua , Li Qi . Vitamin D Receptor Gene TaqI Polymorphisms and Steroid Responsiveness in Childhood Nephrotic Syndrome. Journal of Kunming Medical University, 2017, 38(10): 60-64.
    [15] Cui Kun Hua , Li Qi . Correlation Between Vitamin D Receptor (VDR) TaqIGene Polymorphism and Bone Metabolism Disorder in Children, s Nephrotic Syndrome. Journal of Kunming Medical University, 2017, 38(11): 69-74.
    [16] Xiang Xi , Li Wan Bi , Zhang Xian , Liu Hua , Wang Yu Ming , Yang Cai , Bai Yun Xia . Correlation between Vitamin D Receptor (VDR) Gene ApaⅠ, BsmⅠ Single Nucleotide Polymorphism and Diabetic Kidney Disease in Type 2 Diabetic Patients. Journal of Kunming Medical University, 2017, 38(08): 79-85.
    [17] Xiang Xi . The Correlation between Vitamin D Receptor Gene FokI Single Nucleotide Polymorphism and Diabetic Kidney Disease. Journal of Kunming Medical University,
    [18] Liu Jin Hong , Fang Ke Wei . E pidemiological Investigation of Urinary Incontinence Among Adult Women in Two Communities in Kunming. Journal of Kunming Medical University, 2016, 37(11): 70-75.
    [19] Ling Yu , Sun Yan Hui , Cui Ji Hua , Wu Jian Min , Song Yu , Li Shu Jin , Liu Xiao Mei . Levels of 25-(OH)D in 0～12 years Old Children in Kunming. Journal of Kunming Medical University, 2016, 37(12): 34-36.
    [20] . Association between the Genetic Polymorphisms of Vitamin D Receptor and Sporadic Breast Cancer Risk in Yunnan Women of Han Nationality. Journal of Kunming Medical University,
    • Supplements(0)
    • Cited By
  • Created with Highcharts 5.0.7Amount of accessChart context menuAbstract Views, HTML Views, PDF Downloads StatisticsAbstract ViewsHTML ViewsPDF Downloads2024-052024-062024-072024-082024-092024-102024-112024-122025-012025-022025-032025-040255075100125
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 50.6 %FULLTEXT: 50.6 %META: 48.2 %META: 48.2 %PDF: 1.1 %PDF: 1.1 %FULLTEXTMETAPDF
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 5.3 %其他: 5.3 %Falkenstein: 1.0 %Falkenstein: 1.0 %San Mateo: 0.1 %San Mateo: 0.1 %上海: 1.6 %上海: 1.6 %伊利诺伊州: 0.1 %伊利诺伊州: 0.1 %保定: 0.1 %保定: 0.1 %六安: 0.1 %六安: 0.1 %内江: 0.1 %内江: 0.1 %包头: 0.1 %包头: 0.1 %北京: 25.8 %北京: 25.8 %十堰: 1.1 %十堰: 1.1 %南京: 0.7 %南京: 0.7 %南昌: 0.1 %南昌: 0.1 %合肥: 0.3 %合肥: 0.3 %哥伦布: 0.4 %哥伦布: 0.4 %嘉兴: 0.4 %嘉兴: 0.4 %天津: 2.3 %天津: 2.3 %安康: 0.1 %安康: 0.1 %宜昌: 0.3 %宜昌: 0.3 %宣城: 1.3 %宣城: 1.3 %宿迁: 0.4 %宿迁: 0.4 %常州: 1.6 %常州: 1.6 %常德: 0.1 %常德: 0.1 %张家口: 2.7 %张家口: 2.7 %徐州: 0.3 %徐州: 0.3 %成都: 0.6 %成都: 0.6 %扬州: 1.4 %扬州: 1.4 %无锡: 0.3 %无锡: 0.3 %昆明: 2.4 %昆明: 2.4 %曲靖: 0.1 %曲靖: 0.1 %朔州: 0.4 %朔州: 0.4 %朝阳: 0.1 %朝阳: 0.1 %杭州: 1.9 %杭州: 1.9 %武汉: 0.7 %武汉: 0.7 %波士顿: 0.1 %波士顿: 0.1 %洛阳: 0.1 %洛阳: 0.1 %济南: 0.1 %济南: 0.1 %济宁: 0.9 %济宁: 0.9 %温州: 1.7 %温州: 1.7 %湖州: 0.3 %湖州: 0.3 %湛江: 0.1 %湛江: 0.1 %漯河: 8.0 %漯河: 8.0 %石家庄: 0.7 %石家庄: 0.7 %红河: 0.3 %红河: 0.3 %芒廷维尤: 16.3 %芒廷维尤: 16.3 %芝加哥: 1.1 %芝加哥: 1.1 %苏州: 0.1 %苏州: 0.1 %衡阳: 0.3 %衡阳: 0.3 %衢州: 0.1 %衢州: 0.1 %襄阳: 0.3 %襄阳: 0.3 %西宁: 9.1 %西宁: 9.1 %西安: 0.3 %西安: 0.3 %贵阳: 0.1 %贵阳: 0.1 %赣州: 0.1 %赣州: 0.1 %辛辛那提: 0.3 %辛辛那提: 0.3 %运城: 0.3 %运城: 0.3 %遵义: 0.1 %遵义: 0.1 %邯郸: 1.4 %邯郸: 1.4 %郑州: 1.0 %郑州: 1.0 %重庆: 0.4 %重庆: 0.4 %金华: 0.1 %金华: 0.1 %长沙: 1.0 %长沙: 1.0 %青岛: 0.1 %青岛: 0.1 %其他FalkensteinSan Mateo上海伊利诺伊州保定六安内江包头北京十堰南京南昌合肥哥伦布嘉兴天津安康宜昌宣城宿迁常州常德张家口徐州成都扬州无锡昆明曲靖朔州朝阳杭州武汉波士顿洛阳济南济宁温州湖州湛江漯河石家庄红河芒廷维尤芝加哥苏州衡阳衢州襄阳西宁西安贵阳赣州辛辛那提运城遵义邯郸郑州重庆金华长沙青岛

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (4105) PDF downloads(101) Cited by()
    Proportional views
    Related

    Copyright © 《昆明医科大学学报》编辑部  滇ICP备00000000号-0

    Publishing: 昆明医科大学学报编辑部

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return