Effect of Blood Purification on Septic Encephalopathy Neuron-specific Enolase

［Abstract］Objective　To investigate the application of blood purification of septic encephalopathy（SAE）of neuron specific enolase（NSE）influence，for clinicians to provide an early diagnosis of septic encephalopathy and treatment methods for the SAE means，improve the rate of septic encephalopathy treatment to reduce morbidity and mortality．Methods　150 cases of septic encephalopathy admitted in our hospital were randomly divided into observation group and control group，75 cases in each group．Patients in the control group received primary disease and vital organ support and comprehensive treatment，patients in the observation group received additional blood purification treatment．The cerebrospinal fluid（CSF） samples of two groups of children diagnosed after 24 hours and 7 days after treatment were collected for routine，biochemical（Gul，LDH，LA）and neuron specific enolase（NSE）check，the blood samples 1，2，3，5，7 days after diagnosis were collected for detection of NSE．Results　 No abnormal biochemical test results were found，Gul was significantly lower than that of normal children （P＜0.05），lactate dehydrogenase（LDH）and La was significantly higher than that of normal children（P＜ 0.05），7 d after the treatment，Gul，LDH，La index in the observation group was similar to normal children（P＞0.05），in control group，7 days after treatment，Gul，LDH，La recovery was significantly lower than those in the observation group；cerebrospinal fluid and peripheral blood NSE levels were compared，and the result showed，3 days before treatment，the patients，NSE levels had no significant difference between two groups，5 d，7 d after treatment the NSE level in observation group was significantly lower than that of the control group，the difference was statistically significant（P＜0.05）．Conclusion　Children with septic encephalopathy have higher blood and CSF NSE increased significantly，blood purification treatment can accelerate the reduction of NSE concentration and improve the cerebrospinal fluid Gul，LDH，La index，plays an important role in the treatment of septic encephalopathy．