The Diagnostic Value of Plasma Fibrinogen and D-dimer for the Progressive Stroke

［Abstract］Objective　To study the diagnostic value of plasma fibrinogen （FIB） and D-dimer （DD） for the progressive stroke．Methods　The 40 patients with progressive stroke，40 patients with complete stroke， and 80 cases of health examination Hebei Xingtai Third Hospital our hospital from Jan 2014 to May 2015 were respectively regarded as the subjects of A group， B group， and C group，respectively. On 24h，3d，7d and 14d after admission，the plasma fibrinogen and D-dimer levels in all groups were detected and compared，the NIHSS scores in A group and B group were compared after admission. Results　Compared with C group， the FIB levels were significantly increased on 24h， 3d， 7d after admission in A group and the FIB levels were obviously increased on 24h， 3d after admission in B group（P＜0.05）；compared with B group， the FIB levels on 24h， 3d， 7d were significantly increased in A group（P＜0.05）；the FIB levels reached to the peak on 3d after admission，began to decrease on 7d after admission， and basically returned to normal on 14d after admission in A group. The FIB levels were gradually admitted to the peak on 24h after admission，began to decrease on 3d after admission， and basically returned to normal on 7d after admission in B group. compared with C group，the DD levels were significantly increased on 24h， 3d， 7d after admission in A group and the FIB levels were obviously increased on 24h， 3d after admission in B group（P＜0.05）; compared with B group，the DD levels on 24h， 3d，7d were significantly increased in A group （P＜0.05）; the DD levels gradually increased on 24h after admission， were admitted to the peak on 7d after admission， and basically returned to normal on 14d after admission in A group. The DD levels gradually increased on 24h after admission，reached to the peak on 3d after admission， and basically returned to normal on 7d after admission in B group；compared with B group，the NIHSS scores on 3d，7d，14d after admission were significantly reduced in A group（P＜0.05）. Conclusion　The monitoring of plasma fibrinogen and D-dimer can help for the early prediction of progressive stroke.