The Effects of Endocannabinoid System on Alcohol-induced Liver Cell Injury

Zhao Xiao Lin

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Zhao Xiao Lin . The Effects of Endocannabinoid System on Alcohol-induced Liver Cell Injury[J]. Journal of Kunming Medical University, 2016, 37(04).

Citation:

Zhao Xiao Lin . The Effects of Endocannabinoid System on Alcohol-induced Liver Cell Injury[J]. Journal of Kunming Medical University, 2016, 37(04).

Zhao Xiao Lin . The Effects of Endocannabinoid System on Alcohol-induced Liver Cell Injury[J]. Journal of Kunming Medical University, 2016, 37(04).

Citation:

Zhao Xiao Lin . The Effects of Endocannabinoid System on Alcohol-induced Liver Cell Injury[J]. Journal of Kunming Medical University, 2016, 37(04).

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The Effects of Endocannabinoid System on Alcohol-induced Liver Cell Injury

Zhao Xiao Lin

(1)West China School of Pharmacy,Sichuan University,Chengdu Sichuan 610041;2)Laboratory of Anesthesia and Critical Care Medicine,Translational Neuroscience Center,West China Hospital of Sichuan University,Chengdu Sichuan 610017;3)Dept. of Anesthesiology,The First Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101;4)Dept. of Anesthesiology,West China Hospital of Sichuan University,Chengdu Sichuan 610041,China)

Abstract

Abstract

［Abstract］Objective　To explore the effects of endocannabinoid system on alcohol-induced liver cell injury. Methods　Alcohol-induced liver cell injury model was established by incubating human liver cell（L-02）and human hepatoma cell（HepG2）with the medium containing alcohol. We screened URB937 concentration range， and evaluated its effecst on alcohol-induced liver cell injury. Results　Treatment with URB937（0.1～50 μmol/L） alone didn’t affect L-02 and HepG2 cell viability（P＞0.05）. Under the situation of alcohol-induced liver cell injury， URB937 co-treatment induced significant cell death and necrosis（P＜0.05）. Conclusions　Elevation of endogenous anandamide concentration would aggravate the cell injury induced by alcohol.
- ［Key words］Alcohol-induced injury；Human liver cell；Human hepatoma cell；Endocannabinoid system,

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